Enhancement of embryo developmental potential by a single administration of GnRH agonist at the time of implantation.

Tesarik J, Hazout A, Mendoza C

Human reproduction (Oxford, England)7 Apr 2004Cited by 84 (Europe PMC)

PMID15070873DOI10.1093/humrep/deh235PepBankPUB-15070873

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanNon-randomized trialEfficacy outcome
In oocyte recipients, triptorelin increased implantation rates versus placebo.
In plain wordsIn oocyte recipients, triptorelin increased implantation rates versus placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseImplantation rate
Study
n: not reported in source
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg onceAs given in this study (human).
Measurements
Implantation rate
36.9%
triptorelin 0.1 mg
Implantation rate
25.1%
placebo
Source sentences
Summary
Oocyte recipients treated with GnRH agonist 6 days after ICSI had higher implantation (36.9 versus 25.1%), twin pregnancy (16.7 versus 3.6%), twin delivery (13.8 versus 2.2%) and birth (31.1 versus 21.5%) rates and similar miscarriage and abortion rates as compared with the placebo group.
1 context sentence(design, population, supporting numbers)
Summary · context
In an oocyte donation programme, oocytes from each donor (n = 138) were shared by two recipients, one of whom was given a single dose of a GnRH agonist (0.1 mg triptorelin) 6 days after ICSI, and the other received placebo at the same time.
Report a problemFND-1507087301
02HumanNon-randomized trialEfficacy outcome
In oocyte recipients, triptorelin increased twin pregnancy rates versus placebo.
In plain wordsIn oocyte recipients, triptorelin increased twin pregnancy rates versus placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseTwin pregnancy rate
Study
n: not reported in source
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg onceAs given in this study (human).
Measurements
Twin pregnancy rate
16.7%
triptorelin 0.1 mg
Twin pregnancy rate
3.6%
placebo
Source sentences
Summary
Oocyte recipients treated with GnRH agonist 6 days after ICSI had higher implantation (36.9 versus 25.1%), twin pregnancy (16.7 versus 3.6%), twin delivery (13.8 versus 2.2%) and birth (31.1 versus 21.5%) rates and similar miscarriage and abortion rates as compared with the placebo group.
1 context sentence(design, population, supporting numbers)
Summary · context
In an oocyte donation programme, oocytes from each donor (n = 138) were shared by two recipients, one of whom was given a single dose of a GnRH agonist (0.1 mg triptorelin) 6 days after ICSI, and the other received placebo at the same time.
Report a problemFND-1507087302
03HumanNon-randomized trialEfficacy outcome
In oocyte recipients, triptorelin increased twin delivery rates versus placebo.
In plain wordsIn oocyte recipients, triptorelin increased twin delivery rates versus placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseTwin delivery rate
Study
n: not reported in source
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg onceAs given in this study (human).
Measurements
Twin delivery rate
13.8%
triptorelin 0.1 mg
Twin delivery rate
2.2%
placebo
Source sentences
Summary
Oocyte recipients treated with GnRH agonist 6 days after ICSI had higher implantation (36.9 versus 25.1%), twin pregnancy (16.7 versus 3.6%), twin delivery (13.8 versus 2.2%) and birth (31.1 versus 21.5%) rates and similar miscarriage and abortion rates as compared with the placebo group.
1 context sentence(design, population, supporting numbers)
Summary · context
In an oocyte donation programme, oocytes from each donor (n = 138) were shared by two recipients, one of whom was given a single dose of a GnRH agonist (0.1 mg triptorelin) 6 days after ICSI, and the other received placebo at the same time.
Report a problemFND-1507087303
04HumanNon-randomized trialEfficacy outcome
In oocyte recipients, triptorelin increased birth rates versus placebo.
In plain wordsIn oocyte recipients, triptorelin increased birth rates versus placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseBirth rate
Study
n: not reported in source
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg onceAs given in this study (human).
Measurements
Birth rate
31.1%
triptorelin 0.1 mg
Birth rate
21.5%
placebo
Source sentences
Summary
Oocyte recipients treated with GnRH agonist 6 days after ICSI had higher implantation (36.9 versus 25.1%), twin pregnancy (16.7 versus 3.6%), twin delivery (13.8 versus 2.2%) and birth (31.1 versus 21.5%) rates and similar miscarriage and abortion rates as compared with the placebo group.
1 context sentence(design, population, supporting numbers)
Summary · context
In an oocyte donation programme, oocytes from each donor (n = 138) were shared by two recipients, one of whom was given a single dose of a GnRH agonist (0.1 mg triptorelin) 6 days after ICSI, and the other received placebo at the same time.
Report a problemFND-1507087304
05HumanNon-randomized trialEfficacy outcome
In oocyte recipients, miscarriage rates were similar with triptorelin and placebo.
In plain wordsIn oocyte recipients, miscarriage rates were similar with triptorelin and placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeMiscarriage rate
Study
n: not reported in source
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg onceAs given in this study (human).
Source sentences
Summary
Oocyte recipients treated with GnRH agonist 6 days after ICSI had higher implantation (36.9 versus 25.1%), twin pregnancy (16.7 versus 3.6%), twin delivery (13.8 versus 2.2%) and birth (31.1 versus 21.5%) rates and similar miscarriage and abortion rates as compared with the placebo group.
1 context sentence(design, population, supporting numbers)
Summary · context
In an oocyte donation programme, oocytes from each donor (n = 138) were shared by two recipients, one of whom was given a single dose of a GnRH agonist (0.1 mg triptorelin) 6 days after ICSI, and the other received placebo at the same time.
Report a problemFND-1507087305
06HumanNon-randomized trialEfficacy outcome
In oocyte recipients, abortion rates were similar with triptorelin and placebo.
In plain wordsIn oocyte recipients, abortion rates were similar with triptorelin and placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeAbortion rate
Study
n: not reported in source
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg onceAs given in this study (human).
Source sentences
Summary
Oocyte recipients treated with GnRH agonist 6 days after ICSI had higher implantation (36.9 versus 25.1%), twin pregnancy (16.7 versus 3.6%), twin delivery (13.8 versus 2.2%) and birth (31.1 versus 21.5%) rates and similar miscarriage and abortion rates as compared with the placebo group.
1 context sentence(design, population, supporting numbers)
Summary · context
In an oocyte donation programme, oocytes from each donor (n = 138) were shared by two recipients, one of whom was given a single dose of a GnRH agonist (0.1 mg triptorelin) 6 days after ICSI, and the other received placebo at the same time.
Report a problemFND-1507087306