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Study · Animal study (in vivo) · rat · 2004

8 results

Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats.

Xue XC, Wu YJ, Gao MT, Li WG, Zhao N, Wang ZL, Bao CJ, Yan Z, Zhang YQ

World journal of gastroenterology1 Apr 2004Cited by 30 (Europe PMC)

PMID15052688 (opens in a new tab)PMCIDPMC4717094 (opens in a new tab)DOI10.3748/wjg.v10.i7.1032 (opens in a new tab)PepBankPUB-15052688
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with induced gastric ulcers, intramuscular and intragastric BPC‑157 apparently reduced the ulcer area.

    In plain wordsIn rats with stomach ulcers, BPC‑157 given by muscle injection or into the stomach reduced the ulcer area.

    Peptide
    BPC-157
    Outcome
    DecreaseUlcer area
    Study

    ratn: not reported in source

    Acute and chronic induced gastric ulcer
    Comparator
    Excipient or saline control
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intragastric or intramuscularAs given in this study (rat).

    Source sentences

    Summary
    Both intramuscular (im) and intragastric (ig) administration of BPC 157 could apparently reduce the ulcer area and accelerate the healing of induced ulcer in different models and the effect of im administered BPC 157 was better than that of ig.
    1 context sentence
    Summary · context
    Gastric pentadecapeptide BPC 157 was administered (initial single or continuous administration) into rats either intragastrically or intramuscularly before (induced acute gastric ulcer) or after (induced chronic gastric ulcer) the applications of inducing agents, and each animal was sacrificed to ob…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with induced gastric ulcers, intramuscular and intragastric BPC‑157 accelerated ulcer healing.

    In plain wordsIn rats with stomach ulcers, BPC‑157 given by muscle injection or into the stomach sped up healing.

    Peptide
    BPC-157
    Outcome
    IncreaseHealing of induced ulcer
    Study

    ratn: not reported in source

    Acute and chronic induced gastric ulcer
    Comparator
    Excipient or saline control
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    Dose not stated · intragastric or intramuscularAs given in this study (rat).

    Source sentences

    Summary
    Both intramuscular (im) and intragastric (ig) administration of BPC 157 could apparently reduce the ulcer area and accelerate the healing of induced ulcer in different models and the effect of im administered BPC 157 was better than that of ig.
    1 context sentence
    Summary · context
    Gastric pentadecapeptide BPC 157 was administered (initial single or continuous administration) into rats either intragastrically or intramuscularly before (induced acute gastric ulcer) or after (induced chronic gastric ulcer) the applications of inducing agents, and each animal was sacrificed to ob…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, BPC‑157 at 400 and 800 ng/kg gave significantly less lesion versus control, with inhibition of ulcer formation between 45.7% and 65.6%.

    In plain wordsIn rats, higher BPC‑157 doses clearly reduced stomach lesions compared with control, blocking ulcer formation by about half to two thirds.

    Peptide
    BPC-157
    Outcome
    DecreaseInhibition of ulcer formation at higher doses
    Study

    ratn: not reported in source

    Acute and chronic induced gastric ulcer
    Comparator
    Excipient or saline control
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    400 ng/kg, 800 ng/kg · intragastric or intramuscularAs given in this study (rat).

    Measurements

    Inhibition ratio of ulcer formation
    45.7 to 65.6%
    BPC 157 400 and 800 ng/kg

    Source sentences

    Summary
    The rats treated with higher dosages (400 ng/kg, 800 ng/kg) of BPC 157 (im and ig) showed significantly less lesion (P<0.01 vs excipient or saline control), the inhibition ratio of ulcer formation varied between 45.7% and 65.6%, from all measurements except 400 ng/kg BPC 157 in pylorus ligation indu…
    1 context sentence
    Summary · context
    Gastric pentadecapeptide BPC 157 was administered (initial single or continuous administration) into rats either intragastrically or intramuscularly before (induced acute gastric ulcer) or after (induced chronic gastric ulcer) the applications of inducing agents, and each animal was sacrificed to ob…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with pylorus ligation induced ulcer, BPC‑157 at 400 ng/kg inhibited ulcer formation by 54.2% (P<0.05).

    In plain wordsIn rats with pylorus-ligation stomach ulcers, BPC‑157 at 400 ng/kg blocked ulcer formation by 54.2% compared with control.

    Peptide
    BPC-157
    Outcome
    DecreaseInhibition of ulcer formation, pylorus ligation model, 400 ng/kg
    Study

    ratn: not reported in source

    Pylorus ligation induced ulcer
    Comparator
    Excipient or saline control
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    400 ng/kg · intragastric or intramuscularAs given in this study (rat).

    Measurements

    Inhibition rate
    54.2%
    BPC 157 400 ng/kg, pylorus ligation model

    Source sentences

    Summary
    The rats treated with higher dosages (400 ng/kg, 800 ng/kg) of BPC 157 (im and ig) showed significantly less lesion (P<0.01 vs excipient or saline control), the inhibition ratio of ulcer formation varied between 45.7% and 65.6%, from all measurements except 400 ng/kg BPC 157 in pylorus ligation indu…
    1 context sentence
    Summary · context
    Gastric pentadecapeptide BPC 157 was administered (initial single or continuous administration) into rats either intragastrically or intramuscularly before (induced acute gastric ulcer) or after (induced chronic gastric ulcer) the applications of inducing agents, and each animal was sacrificed to ob…
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In three rat ulcer models, intramuscular BPC‑157 at 800 ng/kg inhibited ulcer formation by 65.5%, 65.6% and 59.9%, better than famotidine.

    In plain wordsIn rats with stomach ulcers, BPC‑157 by muscle injection blocked ulcer formation more than famotidine did.

    Peptide
    BPC-157
    Outcome
    DecreaseInhibition of ulcer formation versus famotidine
    Study

    ratn: not reported in source

    Acute and chronic induced gastric ulcer
    Comparator
    Famotidine
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    800 ng/kg · intramuscularAs given in this study (rat).

    Measurements

    Inhibition ratio of ulcer formation
    65.5%
    BPC 157 800 ng/kg im, first model
    Inhibition ratio of ulcer formation
    65.6%
    BPC 157 800 ng/kg im, second model
    Inhibition ratio of ulcer formation
    59.9%
    BPC 157 800 ng/kg im, third model

    Source sentences

    Summary
    When im administered (800 ng/kg BPC 157) in three models, the inhibition ratio of ulcer formation was 65.5%, 65.6% and 59.9%, respectively, which was better than that of famotidine (its inhibition rate was 60.8%, 57.2% and 34.3%, respectively).
    1 context sentence
    Summary · context
    Gastric pentadecapeptide BPC 157 was administered (initial single or continuous administration) into rats either intragastrically or intramuscularly before (induced acute gastric ulcer) or after (induced chronic gastric ulcer) the applications of inducing agents, and each animal was sacrificed to ob…
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic acetate induced gastric ulcer, continuous BPC‑157 accelerated rebuilding of glandular epithelium (P<0.05 at 200 ng/kg; P<0.01 at 400 and 800 ng/kg).

    In plain wordsIn rats with long-lasting stomach ulcers, repeated BPC‑157 sped up regrowth of the stomach gland lining compared with control.

    Peptide
    BPC-157
    Outcome
    IncreaseRebuilding of glandular epithelium in chronic ulcer
    Study

    ratn: not reported in source

    Chronic acetate induced gastric ulcer
    Comparator
    Excipient or saline control
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    200 ng/kg, 400 ng/kg, 800 ng/kg · intragastric or intramuscularAs given in this study (rat).

    Source sentences

    Summary
    Continuous application of BPC 157 (in chronic acetate induced gastric ulcer) could accelerate rebuilding of glandular epithelium and formation of granulation tissue (P<0.05 at 200 ng/kg and P<0.01 at 400 ng/kg and 800 ng/kg vs excipient or saline control).
    1 context sentence
    Summary · context
    Gastric pentadecapeptide BPC 157 was administered (initial single or continuous administration) into rats either intragastrically or intramuscularly before (induced acute gastric ulcer) or after (induced chronic gastric ulcer) the applications of inducing agents, and each animal was sacrificed to ob…
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic acetate induced gastric ulcer, continuous BPC‑157 accelerated formation of granulation tissue (P<0.05 at 200 ng/kg; P<0.01 at 400 and 800 ng/kg).

    In plain wordsIn rats with long-lasting stomach ulcers, repeated BPC‑157 sped up formation of new repair tissue compared with control.

    Peptide
    BPC-157
    Outcome
    IncreaseFormation of granulation tissue in chronic ulcer
    Study

    ratn: not reported in source

    Chronic acetate induced gastric ulcer
    Comparator
    Excipient or saline control
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    200 ng/kg, 400 ng/kg, 800 ng/kg · intragastric or intramuscularAs given in this study (rat).

    Source sentences

    Summary
    Continuous application of BPC 157 (in chronic acetate induced gastric ulcer) could accelerate rebuilding of glandular epithelium and formation of granulation tissue (P<0.05 at 200 ng/kg and P<0.01 at 400 ng/kg and 800 ng/kg vs excipient or saline control).
    1 context sentence
    Summary · context
    Gastric pentadecapeptide BPC 157 was administered (initial single or continuous administration) into rats either intragastrically or intramuscularly before (induced acute gastric ulcer) or after (induced chronic gastric ulcer) the applications of inducing agents, and each animal was sacrificed to ob…
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with gastric ulcers, intramuscular BPC‑157 was more effective than intragastric BPC‑157, and its effective dosage was lower.

    In plain wordsIn rats with stomach ulcers, BPC‑157 by muscle injection worked better than BPC‑157 into the stomach, at a lower dose.

    Peptide
    BPC-157
    Outcome
    IncreaseIntramuscular versus intragastric administration
    Study

    ratn: not reported in source

    Acute and chronic induced gastric ulcer
    Comparator
    Intragastric BPC 157
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intragastric or intramuscularAs given in this study (rat).

    Source sentences

    Summary
    The effect of im administration of BPC 157 is better than that of ig, and the effective dosage of the former is lower than that of the latter.
    2 context sentences
    Summary · context
    Both intramuscular (im) and intragastric (ig) administration of BPC 157 could apparently reduce the ulcer area and accelerate the healing of induced ulcer in different models and the effect of im administered BPC 157 was better than that of ig.
    Summary · context
    Gastric pentadecapeptide BPC 157 was administered (initial single or continuous administration) into rats either intragastrically or intramuscularly before (induced acute gastric ulcer) or after (induced chronic gastric ulcer) the applications of inducing agents, and each animal was sacrificed to ob…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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