Thymosin-beta4 inhibits corneal epithelial cell apoptosis after ethanol exposure in vitro.

Sosne G, Siddiqi A, Kurpakus-Wheater M

Investigative ophthalmology & visual science1 Apr 2004Cited by 68 (Europe PMC)

PMID15037574DOI10.1167/iovs.03-1002PepBankPUB-15037574

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In ethanol-exposed human corneal epithelial cells, thymosin beta‑4 decreased deleterious mitochondrial alterations.
In plain wordsIn cells, thymosin beta‑4 reduced harmful changes in mitochondria after ethanol exposure.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseMitochondrial alterations after ethanol
Study
humann: not reported in source
human corneal epithelial cells exposed to ethanol
Comparator
Ethanol-exposed untreated cells
Outcome group
Mitochondrial function · Eye
Studied dose
Dose not stated
Source sentences
Summary
Tbeta(4) treatment decreased deleterious mitochondrial alterations
1 context sentence(design, population, supporting numbers)
Summary · context
Nontransformed human corneal epithelial cells (HCECs) at passage 4 were untreated or treated with ethanol (20% for 20 seconds) or a combination of ethanol and Tbeta(4).
Report a problemFND-1503757401
02LabIn vitro (cells)Mechanism
In ethanol-exposed human corneal epithelial cells, thymosin beta‑4 significantly decreased cytochrome c release from mitochondria.
In plain wordsIn cells, thymosin beta‑4 reduced the release of cytochrome c from mitochondria after ethanol exposure.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCytochrome c release from mitochondria
Study
humann: not reported in source
human corneal epithelial cells exposed to ethanol
Comparator
Ethanol-exposed untreated cells
Outcome group
Mitochondrial function · Eye
Studied dose
Dose not stated
Source sentences
Summary
significantly decreased cytochrome c release from mitochondria, and increased Bcl-2 expression in ethanol-exposed human corneal epithelial cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Nontransformed human corneal epithelial cells (HCECs) at passage 4 were untreated or treated with ethanol (20% for 20 seconds) or a combination of ethanol and Tbeta(4).
Report a problemFND-1503757402
03LabIn vitro (cells)Mechanism
In ethanol-exposed human corneal epithelial cells, thymosin beta‑4 increased Bcl-2 expression.
In plain wordsIn cells, thymosin beta‑4 raised Bcl-2 expression after ethanol exposure.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseBcl-2 expression
Study
humann: not reported in source
human corneal epithelial cells exposed to ethanol
Comparator
Ethanol-exposed untreated cells
Outcome group
Cell viability and death · Eye
Studied dose
Dose not stated
Source sentences
Summary
increased Bcl-2 expression in ethanol-exposed human corneal epithelial cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Nontransformed human corneal epithelial cells (HCECs) at passage 4 were untreated or treated with ethanol (20% for 20 seconds) or a combination of ethanol and Tbeta(4).
Report a problemFND-1503757403
04LabIn vitro (cells)Mechanism
In ethanol-exposed corneal epithelium, thymosin beta‑4 inhibited caspase-2, -3, -8 and -9 activity, with caspase-8 showing the most significant inhibition.
In plain wordsIn cells, thymosin beta‑4 lowered the activity of four caspase enzymes after ethanol exposure, most strongly caspase-8.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCaspase-2, -3, -8 and -9 activity
Study
humann: not reported in source
human corneal epithelial cells exposed to ethanol
Comparator
Ethanol-exposed untreated cells
Outcome group
Cell viability and death · Eye
Studied dose
Dose not stated
Source sentences
Summary
In ethanol-exposed corneal epithelium Tbeta(4) treatment inhibited caspase-2, -3, -8, and -9 activity, with caspase-8 showing the most significant inhibition.
1 context sentence(design, population, supporting numbers)
Summary · context
Nontransformed human corneal epithelial cells (HCECs) at passage 4 were untreated or treated with ethanol (20% for 20 seconds) or a combination of ethanol and Tbeta(4).
Report a problemFND-1503757404
05LabIn vitro (cells)Efficacy outcome
In ethanol-exposed human corneal epithelial cells, thymosin beta‑4 had no significant effect on proliferation.
In plain wordsIn cells, thymosin beta‑4 did not significantly change cell growth after ethanol exposure.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeCell proliferation after ethanol exposure
Study
humann: not reported in source
human corneal epithelial cells exposed to ethanol
Comparator
Ethanol-exposed untreated cells
Outcome group
Cell viability and death · Eye
Studied dose
Dose not stated
Source sentences
Summary
Tbeta(4) treatment resulted in no significant effect on the proliferation of human corneal epithelial cells after ethanol exposure.
1 context sentence(design, population, supporting numbers)
Summary · context
Nontransformed human corneal epithelial cells (HCECs) at passage 4 were untreated or treated with ethanol (20% for 20 seconds) or a combination of ethanol and Tbeta(4).
Report a problemFND-1503757405

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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