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Study · In vitro (cells) · 2004

7 results

Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts.

Bilban M, Ghaffari-Tabrizi N, Hintermann E, Bauer S, Molzer S, Zoratti C, Malli R, Sharabi A, Hiden U, Graier W, Knöfler M, Andreae F, Wagner O, Quaranta V, Desoye G

Journal of cell science1 Mar 2004Cited by 273 (Europe PMC)

PMID15020672 (opens in a new tab)DOI10.1242/jcs.00971 (opens in a new tab)PepBankPUB-15020672
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In isolated human first trimester trophoblasts, Kp-10, but not other kisspeptins, increased intracellular calcium.

    In plain wordsIn human placenta cells, kisspeptin‑10 raised calcium inside the cells, but other kisspeptins did not.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseIntracellular Ca2+ level
    Study

    humann: not reported in source

    isolated first trimester trophoblasts
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts.
  2. 02LabIn vitro (cells)Activity measurement

    In human trophoblast explant and transwell assays, Kp-10 inhibited trophoblast migration.

    In plain wordsIn human placenta cell tests, kisspeptin‑10 slowed cell migration.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseTrophoblast migration
    Study

    humann: not reported in source

    human trophoblast explant and transwell assay
    Outcome group
    Cell proliferation and differentiation · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kp-10 inhibited trophoblast migration in an explant as well as transwell assay without affecting proliferation.
  3. 03LabIn vitro (cells)Activity measurement

    In human trophoblast assays, Kp-10 did not affect proliferation.

    In plain wordsIn human placenta cell tests, kisspeptin‑10 did not change cell growth.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeTrophoblast proliferation
    Study

    humann: not reported in source

    human trophoblast explant and transwell assay
    Outcome group
    Cell proliferation and differentiation · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kp-10 inhibited trophoblast migration in an explant as well as transwell assay without affecting proliferation.
  4. 04LabIn vitro (cells)Mechanism

    In isolated human trophoblasts, Kp-10 suppressed motility, and this paralleled suppressed gelatinolytic activity.

    In plain wordsIn human placenta cells, kisspeptin‑10 reduced cell movement together with lower gelatin-digesting activity.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseGelatinolytic activity of trophoblasts
    Study

    humann: not reported in source

    isolated first trimester trophoblasts
    Outcome group
    Cell proliferation and differentiation · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Suppressed motility was paralleled with suppressed gelatinolytic activity of isolated trophoblasts.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 05LabEndogenous levelEx vivo tissueOther

    In human trophoblasts, KiSS-1 (kisspeptin gene) and its receptor were expressed at higher levels in the first trimester than at term.

    In plain wordsIn human placenta cells, the genes for the body's own kisspeptin and its receptor were more active in early pregnancy than at term.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKiSS-1 and KiSS-1R expression in first trimester versus term trophoblasts
    Study

    humann: not reported in source

    human placental trophoblasts
    Comparator
    term trophoblasts
    Outcome group
    Endogenous peptide levels · Reproductive and sexual health

    Source sentences

    Summary
    In this 'invasion cluster', KiSS-1 and its G-protein-coupled receptor KiSS-1R were expressed at higher levels in first trimester trophoblasts than at term of gestation.
    1 context sentence
    Summary · context
    To identify molecules that regulate trophoblast invasion, mRNA signatures of trophoblast cells isolated from first trimester (high invasiveness) and term placentae (no/low invasiveness) were compared using U95A GeneChip microarrays yielding 220 invasion/migration-related genes.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 06LabEndogenous levelEx vivo tissueOther

    Kp-10 was identified in conditioned medium of human first trimester trophoblast.

    In plain wordsHuman placenta cells from early pregnancy released the body's own kisspeptin‑10 into their culture medium.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKp-10 in conditioned medium of first trimester trophoblast
    Study

    humann: not reported in source

    human trophoblast conditioned medium
    Outcome group
    Endogenous peptide levels · Reproductive and sexual health

    Source sentences

    Summary
    We identified Kp-10, a dekapeptide derived from the primary translation product, in conditioned medium of first trimester human trophoblast.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  3. 07LabEndogenous levelEx vivo tissueOther

    In human trophoblasts, KiSS-1 (kisspeptin gene) and its receptor mRNA and protein were localized to the trophoblast compartment, and KiSS-1 was expressed only in the villous trophoblast.

    In plain wordsIn human placenta cells, the body's own kisspeptin gene was active only in villous trophoblast cells, while its receptor was also in extravillous cells.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableLocalization of KiSS-1 and KiSS-1R in trophoblast
    Study

    humann: not reported in source

    human placental trophoblasts
    Outcome group
    Endogenous peptide levels · Reproductive and sexual health

    Source sentences

    Summary
    Receptor and ligand mRNA and protein were localized to the trophoblast compartment.
    1 context sentence
    Summary · context
    In contrast to KiSS-1, which is only expressed in the villous trophoblast, KiSS-1R was also found in the extravillous trophoblast, suggesting endocrine/paracrine activation mechanisms.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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