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Study · In vitro (cells) · rana esculenta · 2004

3 results

Melanogenic response of the Kupffer cells of Rana esculenta L to melanocyte stimulating hormone.

Guida G, Zanna P, Gallone A, Argenzio E, Cicero R

Pigment cell research1 Apr 2004Cited by 6 (Europe PMC)

PMID15016301 (opens in a new tab)DOI10.1046/j.1600-0749.2003.00118.x (opens in a new tab)PepBankPUB-15016301
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In primary cultures of Rana esculenta Kupffer cells, NDP-MSH increased tyrosinase gene transcription within the first 24 h of stimulation.

    In plain wordsIn frog liver cells grown in a dish, NDP-MSH raised tyrosinase gene activity within the first day.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseTyrosinase gene transcription
    Study

    Rana esculentan: not reported in source

    primary cultures of Kupffer cells
    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Incubation of the cells with NDP-MSH increases tyrosinase gene transcription, within the first 24 h of stimulation.
    1 context sentence
    Summary · context
    In order to study this regulation, we analysed the effects of NDP-MSH on the levels of expression of the tyrosinase gene and on dopa-oxidase activity, using primary cultures of KCs.
  2. 02LabIn vitro (cells)Mechanism

    In primary cultures of Rana esculenta Kupffer cells, NDP-MSH treatment always activated the tyrosinase system.

    In plain wordsIn frog liver cells grown in a dish, NDP-MSH switched on the tyrosinase system each time.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseTyrosinase system activation
    Study

    Rana esculentan: not reported in source

    primary cultures of Kupffer cells
    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while the hormonal treatment always activated the KC tyrosinase system
    1 context sentence
    Summary · context
    In order to study this regulation, we analysed the effects of NDP-MSH on the levels of expression of the tyrosinase gene and on dopa-oxidase activity, using primary cultures of KCs.
  3. 03LabIn vitro (cells)Mechanism

    In primary cultures of Rana esculenta Kupffer cells, NDP-MSH did not produce significant increases in intracellular cAMP.

    In plain wordsIn frog liver cells grown in a dish, NDP-MSH did not raise cAMP in a meaningful way.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeIntracellular cAMP
    Study

    Rana esculentan: not reported in source

    primary cultures of Kupffer cells
    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Assays of cAMP levels in cells stimulated with NDP-MSH demonstrated that the hormone does not produce significant increases in intracellular cAMP.
    1 context sentence
    Summary · context
    In order to study this regulation, we analysed the effects of NDP-MSH on the levels of expression of the tyrosinase gene and on dopa-oxidase activity, using primary cultures of KCs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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