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Study · In vitro (cells) · rat · 2004

6 results

Humanin rescues cortical neurons from prion-peptide-induced apoptosis.

Sponne I, Fifre A, Koziel V, Kriem B, Oster T, Pillot T

Molecular and cellular neurosciences1 Jan 2004Cited by 58 (Europe PMC)

PMID14962743 (opens in a new tab)DOI10.1016/j.mcn.2003.09.017 (opens in a new tab)PepBankPUB-14962743
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In rat cortical neurons, 10 microM humanin prevented cell death induced by the soluble PrP(118-135) fragment.

    In plain wordsIn rat nerve cells grown in the lab, humanin stopped cell death caused by a toxic prion peptide fragment.

    Peptide
    Humanin
    Outcome
    DecreasePrP(118-135)-induced cell death
    Study

    ratn: not reported in source

    Cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 microMAs given in this study (rat).

    Measurements

    Humanin concentration
    10 microM
    rat cortical neurons

    Source sentences

    Summary
    We found that the incubation of rat cortical neurons with 10 microM HN prevented soluble PrP(118-135) fragment-induced cell death concomitantly with inhibition of apoptotic events.
    1 context sentence
    Summary · context
    We thus addressed the question of whether HN might modulate the apoptosis induced by the soluble PrP(118-135) fragment.
  2. 02LabIn vitro (cells)Efficacy outcome

    In rat cortical neurons, 10 microM humanin inhibited apoptotic events induced by the soluble PrP(118-135) fragment.

    In plain wordsIn rat nerve cells grown in the lab, humanin reduced the signs of programmed cell death caused by a toxic prion peptide fragment.

    Peptide
    Humanin
    Outcome
    DecreaseApoptotic events induced by PrP(118-135)
    Study

    ratn: not reported in source

    Cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 microMAs given in this study (rat).

    Measurements

    Humanin concentration
    10 microM
    rat cortical neurons

    Source sentences

    Summary
    We found that the incubation of rat cortical neurons with 10 microM HN prevented soluble PrP(118-135) fragment-induced cell death concomitantly with inhibition of apoptotic events.
    1 context sentence
    Summary · context
    We thus addressed the question of whether HN might modulate the apoptosis induced by the soluble PrP(118-135) fragment.
  3. 03LabIn vitro (cells)Mechanism

    In rat cortical neurons, the protective effects of HN and HNG did not require preincubation with the PrP(118-135) fragment.

    In plain wordsIn rat nerve cells, humanin and HNG protected without first being mixed with the prion peptide fragment.

    Peptide
    Humanin
    Outcome
    Not applicableNeed for preincubation with PrP(118-135)
    Study

    ratn: not reported in source

    Cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effects of HN and HNG peptides did not require a preincubation with the PrP(118-135) fragment, strongly suggesting that these peptides rescue cells independently of a direct interaction with the prion peptide.
    1 context sentence
    Summary · context
    We thus addressed the question of whether HN might modulate the apoptosis induced by the soluble PrP(118-135) fragment.
  4. 04LabIn vitro (cells)Efficacy outcome

    In rat cortical neurons, humanin had no effect on cell death induced by the fibrillar PrP(106-126) peptide.

    In plain wordsIn rat nerve cells grown in the lab, humanin did not stop cell death caused by a different, fibrillar prion peptide.

    Peptide
    Humanin
    Outcome
    No significant changeFibrillar PrP(106-126)-induced cell death
    Study

    ratn: not reported in source

    Cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN had no effect on the fibrillar PrP(106-126) peptide-induced cell death.
    1 context sentence
    Summary · context
    We thus addressed the question of whether HN might modulate the apoptosis induced by the soluble PrP(118-135) fragment.

Studies that did not test the peptide alone2

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 05LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    In rat cortical neurons, the humanin variant HNG showed a 500-fold increase in protective activity against PrP(118-135)-induced cell death.

    In plain wordsIn rat nerve cells, a modified humanin called HNG protected far more strongly (500-fold) than the natural form.

    Peptide
    Humanin
    Outcome
    IncreaseProtective activity of the HNG variant
    Study

    ratn: not reported in source

    Cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition

    Measurements

    Increase in protective activity
    500 fold
    HNG

    Source sentences

    Summary
    An HN variant, termed HNG, exhibited a 500-fold increase in the protective activity in cortical neurons
    1 context sentence
    Summary · context
    We thus addressed the question of whether HN might modulate the apoptosis induced by the soluble PrP(118-135) fragment.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 06LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    In rat cortical neurons, the humanin variant HNA showed no protective effect.

    In plain wordsIn rat nerve cells, a modified humanin called HNA did not protect.

    Peptide
    Humanin
    Outcome
    No significant changeProtective activity of the HNA variant
    Study

    ratn: not reported in source

    Cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    whereas the HNA variant displayed no protective effect.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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