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Study · In vitro (cells) · 2004

2 results

Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants.

Hashimoto Y, Tsukamoto E, Niikura T, Yamagishi Y, Ishizaka M, Aiso S, Takashima A, Nishimoto I

Journal of neuroscience research1 Feb 2004Cited by 21 (Europe PMC)

PMID14743455 (opens in a new tab)DOI10.1002/jnr.10861 (opens in a new tab)PepBankPUB-14743455
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In neuronal cells, humanin inhibited the death caused by N-terminal presenilin 1 mutants, whereas IGF-I did not.

    In plain wordsIn cells, humanin blocked nerve cell death caused by one group of Alzheimer's-linked presenilin 1 mutants, but IGF-I did not.

    Peptide
    Humanin
    Outcome
    DecreaseNeuronal death caused by N-terminal PS1 mutants
    Study

    n: not reported in source

    Comparator
    IGF-I
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The former toxicity was resistant to the specific NADPH oxidase inhibitor apocynin and was inhibited by Humanin (HN), a newly identified neuroprotective factor against Alzheimer's disease (AD)-relevant insults, but not by insulin-like growth factor-I (IGF-I).
    1 context sentence
    Summary · context
    In this study, we examined 27 different FAD-linked mutants of PS1, and found that PS1 mutants with mutations in the N-terminal fragment caused NOS inhibitor (NOSI)-sensitive neuronal cell death; in contrast, the PS1 mutants with mutations in the C-terminal fragment caused NOSI-resistant neuronal cell death.
  2. 02LabIn vitro (cells)Efficacy outcome

    In neuronal cells, humanin and IGF-I both inhibited the death caused by C-terminal presenilin 1 mutants.

    In plain wordsIn cells, humanin blocked nerve cell death caused by the other group of Alzheimer's-linked presenilin 1 mutants, as did IGF-I.

    Peptide
    Humanin
    Outcome
    DecreaseNeuronal death caused by C-terminal PS1 mutants
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, the latter toxicity was sensitive to apocynin and inhibited by both IGF-I and HN.
    1 context sentence
    Summary · context
    In this study, we examined 27 different FAD-linked mutants of PS1, and found that PS1 mutants with mutations in the N-terminal fragment caused NOS inhibitor (NOSI)-sensitive neuronal cell death; in contrast, the PS1 mutants with mutations in the C-terminal fragment caused NOSI-resistant neuronal cell death.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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