Oxytocin receptor is expressed in the penis and mediates an estrogen-dependent smooth muscle contractility.

Vignozzi L, Filippi S, Luconi M, Morelli A, Mancina R, Marini M, Vannelli GB, Granchi S, Orlando C, Gelmini S, Ledda F, Forti G, Maggi M

Endocrinology22 Dec 2003Cited by 48 (Europe PMC)

PMID14691010DOI10.1210/en.2003-0962PepBankPUB-14691010

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

1 result from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In corpus cavernosum tissue, oxytocin mediated contractility through its receptor.
In plain wordsIn lab tests, oxytocin caused penile tissue to contract.
Peptide
Oxytocin
Outcome
IncreaseCorpus cavernosum contractility
Study
n: not reported in source
Corpus cavernosum
Outcome group
Sexual function · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
OT receptor is expressed in the penis at a concentration similar to that present in other portions of the male genital tract and mediates CC contractility.
Report a problemFND-1469101001

Studies that did not test the peptide alone5

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

02LabNot a test of Triptorelin (Trelstar, Decapeptyl) aloneEx vivo tissueMechanism
In rabbit corpus cavernosum, oxytocin responsiveness decreased after triptorelin-induced hypogonadism.
In plain wordsIn lab tests, penile tissue from rabbits with triptorelin-induced hormone deficiency responded less to oxytocin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseOxytocin responsiveness after induced hypogonadism
Study
rabbitn: not reported in source
Corpus cavernosum from rabbits with induced hypogonadotropic hypogonadism
Outcome group
Sexual function · Reproductive and sexual health
Source sentences
Summary
we found that in a rabbit model of hypogonadotropic hypogonadism (induced by a single administration of the long-acting GnRH agonist triptorelin pamoate, 2.9 mg/kg), OT responsiveness was strongly reduced
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1469101002
03LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In hypogonadal rabbit corpus cavernosum, estradiol valerate completely restored responsiveness to oxytocin.
In plain wordsIn lab tests, estradiol restored the response to oxytocin in penile tissue from hormone-deficient rabbits.
Peptide
Oxytocin
Outcome
IncreaseOxytocin responsiveness with estradiol
Study
rabbitn: not reported in source
Hypogonadal rabbit corpus cavernosum
Outcome group
Sexual function · Reproductive and sexual health
Source sentences
Summary
In fact, we found that in a rabbit model of hypogonadotropic hypogonadism (induced by a single administration of the long-acting GnRH agonist triptorelin pamoate, 2.9 mg/kg), OT responsiveness was strongly reduced and was completely restored by estradiol valerate (3.3 mg/kg weekly), but not by testo…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1469101003
04LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In hypogonadal rabbit corpus cavernosum, testosterone enanthate did not restore responsiveness to oxytocin.
In plain wordsIn lab tests, testosterone did not restore the response to oxytocin in penile tissue from hormone-deficient rabbits.
Peptide
Oxytocin
Outcome
No significant changeOxytocin responsiveness with testosterone
Study
rabbitn: not reported in source
Hypogonadal rabbit corpus cavernosum
Outcome group
Sexual function · Reproductive and sexual health
Source sentences
Summary
In fact, we found that in a rabbit model of hypogonadotropic hypogonadism (induced by a single administration of the long-acting GnRH agonist triptorelin pamoate, 2.9 mg/kg), OT responsiveness was strongly reduced and was completely restored by estradiol valerate (3.3 mg/kg weekly), but not by testo…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1469101004
05LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In rabbit corpus cavernosum, letrozole reduced responsiveness to oxytocin stimulation.
In plain wordsIn lab tests, penile tissue from letrozole-treated rabbits responded less to oxytocin.
Peptide
Oxytocin
Outcome
DecreaseOxytocin responsiveness with letrozole
Study
rabbitn: not reported in source
Rabbit corpus cavernosum
Outcome group
Sexual function · Reproductive and sexual health
Source sentences
Summary
Both treatments significantly reduced CC responsiveness to OT stimulation.
1 context sentence(design, population, supporting numbers)
Summary · context
We therefore treated adult rabbits with an aromatase inhibitor (letrozole, 2.5 mg/kg) or an antiestrogen (tamoxifen, 0.25 mg/kg) for 3 wk.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1469101005
06LabNot a test of Oxytocin aloneEx vivo tissueMechanism
In rabbit corpus cavernosum, tamoxifen reduced responsiveness to oxytocin stimulation.
In plain wordsIn lab tests, penile tissue from tamoxifen-treated rabbits responded less to oxytocin.
Peptide
Oxytocin
Outcome
DecreaseOxytocin responsiveness with tamoxifen
Study
rabbitn: not reported in source
Rabbit corpus cavernosum
Outcome group
Sexual function · Reproductive and sexual health
Source sentences
Summary
Both treatments significantly reduced CC responsiveness to OT stimulation.
1 context sentence(design, population, supporting numbers)
Summary · context
We therefore treated adult rabbits with an aromatase inhibitor (letrozole, 2.5 mg/kg) or an antiestrogen (tamoxifen, 0.25 mg/kg) for 3 wk.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1469101006

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 2
21 Oct 2026, 18:59 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

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