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Study · In vitro (cells) · chinese hamster · 2003

2 results

Rapid desensitisation of the GH secretagogue (ghrelin) receptor to hexarelin in vitro.

Orkin RD, New DI, Norman D, Chew SL, Clark AJ, Grossman AB, Korbonits M

Journal of endocrinological investigation1 Aug 2003Cited by 16 (Europe PMC)

PMID14669829 (opens in a new tab)DOI10.1007/bf03347357 (opens in a new tab)PepBankPUB-14669829
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In CHO cells expressing human GHS-R 1a, hexarelin produced a significant, specific calcium response that was absent in mock-transfected cells.

    In plain wordsIn cells carrying the human ghrelin receptor, hexarelin triggered a calcium response that cells without the receptor did not show.

    Peptide
    Hexarelin
    Outcome
    IncreaseCalcium response to hexarelin in GHS-R cells
    Study

    Chinese hamstern: not reported in source

    CHO cells transfected with human type 1a GHS-R
    Comparator
    Mock-transfected cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    10(-10) to 10(-7) MAs given in this study (Chinese hamster).

    Source sentences

    Summary
    Cells transfected with the GHS-R cDNA demonstrated a significant and specific calcium response to hexarelin that was not observed in mock-transfected cells.
    1 context sentence
    Summary · context
    Chinese hamster ovary cells were transiently transfected with cDNA encoding the human type 1a GHS-R.
  2. 02LabIn vitro (cells)Mechanism

    In CHO cells expressing human GHS-R 1a, the calcium response to hexarelin showed marked desensitisation 2-5 min after the first 10(-7) M dose.

    In plain wordsIn cells carrying the human ghrelin receptor, the calcium response to hexarelin faded strongly within minutes after a first dose.

    Peptide
    Hexarelin
    Outcome
    DecreaseDesensitisation of calcium response to repeated hexarelin
    Study

    Chinese hamstern: not reported in source

    CHO cells transfected with human type 1a GHS-R
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    10(-7) MAs given in this study (Chinese hamster).

    Source sentences

    Summary
    Marked desensitisation of the calcium response to hexarelin was observed 2-5 min after the first dose of hexarelin (10(-7) M) was administered.
    1 context sentence
    Summary · context
    Chinese hamster ovary cells were transiently transfected with cDNA encoding the human type 1a GHS-R.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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