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Study · In vitro (cells) · rat · 2004

4 results

Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro.

Pang JJ, Xu RK, Xu XB, Cao JM, Ni C, Zhu WL, Asotra K, Chen MC, Chen C

American journal of physiology. Heart and circulatory physiology13 Nov 2003Cited by 51 (Europe PMC)

PMID14615277 (opens in a new tab)DOI10.1152/ajpheart.00648.2003 (opens in a new tab)PepBankPUB-14615277
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured neonatal rat cardiomyocytes, hexarelin significantly decreased angiotensin II-induced apoptosis.

    In plain wordsIn rat heart muscle cells in the lab, hexarelin reduced cell death caused by angiotensin II.

    Peptide
    Hexarelin
    Outcome
    DecreaseANG II-induced cardiomyocyte apoptosis
    Study

    ratn: not reported in source

    cultured neonatal rat cardiomyocytes stimulated with ANG II
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 micromol/l · added to cell cultureAs given in this study (rat).

    Source sentences

    Summary
    Administration of 0.1 micromol/l hexarelin significantly decreased this ANG II-induced apoptosis and DNA fragmentation and increased myocyte viability.
    1 context sentence
    Summary · context
    Cultured cardiomyocytes from neonatal rats were stimulated with ANG II.
  2. 02LabIn vitro (cells)Efficacy outcome

    In cultured neonatal rat cardiomyocytes, hexarelin significantly decreased angiotensin II-induced DNA fragmentation.

    In plain wordsIn rat heart muscle cells in the lab, hexarelin reduced DNA breakdown caused by angiotensin II.

    Peptide
    Hexarelin
    Outcome
    DecreaseANG II-induced DNA fragmentation
    Study

    ratn: not reported in source

    cultured neonatal rat cardiomyocytes stimulated with ANG II
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 micromol/l · added to cell cultureAs given in this study (rat).

    Source sentences

    Summary
    Administration of 0.1 micromol/l hexarelin significantly decreased this ANG II-induced apoptosis and DNA fragmentation and increased myocyte viability.
    1 context sentence
    Summary · context
    Cultured cardiomyocytes from neonatal rats were stimulated with ANG II.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cultured neonatal rat cardiomyocytes exposed to angiotensin II, hexarelin increased myocyte viability.

    In plain wordsIn rat heart muscle cells in the lab, hexarelin kept more cells alive after angiotensin II exposure.

    Peptide
    Hexarelin
    Outcome
    IncreaseMyocyte viability
    Study

    ratn: not reported in source

    cultured neonatal rat cardiomyocytes stimulated with ANG II
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 micromol/l · added to cell cultureAs given in this study (rat).

    Source sentences

    Summary
    Administration of 0.1 micromol/l hexarelin significantly decreased this ANG II-induced apoptosis and DNA fragmentation and increased myocyte viability.
    1 context sentence
    Summary · context
    Cultured cardiomyocytes from neonatal rats were stimulated with ANG II.
  4. 04LabIn vitro (cells)Mechanism

    In cultured neonatal rat cardiomyocytes, GHS-R mRNA was abundantly expressed and was upregulated after hexarelin administration.

    In plain wordsIn rat heart muscle cells in the lab, hexarelin increased the mRNA of its own receptor, GHS-R.

    Peptide
    Hexarelin
    Outcome
    IncreaseGHS-R mRNA expression
    Study

    ratn: not reported in source

    cultured neonatal rat cardiomyocytes stimulated with ANG II
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHS-R mRNA was abundantly expressed in cardiomyocytes and was upregulated after administration of hexarelin.
    1 context sentence
    Summary · context
    Cultured cardiomyocytes from neonatal rats were stimulated with ANG II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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