Pituitary and gonadal effects of GnRH (gonadotropin releasing hormone) analogues in two peripubertal female rat models.

Roth C, Hegemann F, Hildebrandt J, Balzer I, Witt A, Wuttke W, Jarry H

Pediatric research6 Nov 2003Cited by 7 (Europe PMC)

PMID14605254DOI10.1203/01.pdr.0000100463.84334.3fPepBankPUB-14605254

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats, triptorelin inhibited pituitary LHbeta mRNA compared with controls.
In plain wordsIn rats, triptorelin reduced pituitary LHbeta gene expression compared with controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreasePituitary LHbeta mRNA
Study
ratn: not reported in source
Prepubertal ovariectomized female rats
Comparator
Controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Pituitary gonadotropin subunit LHbeta mRNA levels were inhibited in all groups except controls
1 context sentence(design, population, supporting numbers)
Summary · context
To compare modes of action and effectiveness of GnRH analogues and assess treatment combinations of agonistic (triptorelin) and antagonistic (cetrorelix acetate) GnRH analogues with established treatment, we used prepubertal 31-d-old ovariectomized female rats.
Report a problemFND-1460525402
02AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats, triptorelin stimulated pituitary GnRH receptor mRNA.
In plain wordsIn rats, triptorelin increased pituitary GnRH receptor gene expression.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePituitary GnRH receptor mRNA
Study
ratn: not reported in source
Prepubertal ovariectomized female rats
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
but pituitary GnRH receptor mRNA was stimulated by agonist yet unaffected by combined analogues.
1 context sentence(design, population, supporting numbers)
Summary · context
To compare modes of action and effectiveness of GnRH analogues and assess treatment combinations of agonistic (triptorelin) and antagonistic (cetrorelix acetate) GnRH analogues with established treatment, we used prepubertal 31-d-old ovariectomized female rats.
Report a problemFND-1460525404
03LabEx vivo tissueMechanism
In explanted rat ovaries, triptorelin did not significantly reduce GnRH receptor mRNA after incubation.
In plain wordsIn lab tests on rat ovaries, triptorelin did not significantly reduce GnRH receptor gene expression.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeOvarian GnRH receptor mRNA
Study
ratn: not reported in source
Explanted rat ovaries
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
10-6 M · 4 hAs given in this study (rat).
Source sentences
Summary
After 4 h, GnRH receptor mRNA levels were significantly reduced by antagonist but not agonist.
1 context sentence(design, population, supporting numbers)
Summary · context
Explanted ovaries were incubated with either analogue, both 10-6 M.
Report a problemFND-1460525406

Studies that did not test the peptide alone3

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

04AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In ovariectomized rats, combined triptorelin and cetrorelix reduced serum LH versus controls.
In plain wordsIn rats, combined triptorelin and cetrorelix reduced blood LH compared with controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSerum LH with combined analogues
Study
ratn: not reported in source
Prepubertal ovariectomized female rats
Comparator
Controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Measurements
LH
0.52 ng/mL
combined agonist/antagonist after 5 d
LH
4.9 ng/mL
controls
Source sentences
Summary
Combined agonist/antagonist was second most effective of the treatments (after 5 d treatment, LH 0.52 +/- 0.15 versus 4.9 +/- 1.1 ng/mL in controls; p < 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
To compare modes of action and effectiveness of GnRH analogues and assess treatment combinations of agonistic (triptorelin) and antagonistic (cetrorelix acetate) GnRH analogues with established treatment, we used prepubertal 31-d-old ovariectomized female rats.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1460525401
05AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In ovariectomized rats, combined triptorelin and cetrorelix inhibited pituitary LHbeta mRNA compared with controls.
In plain wordsIn rats, combined triptorelin and cetrorelix reduced pituitary LHbeta gene expression compared with controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreasePituitary LHbeta mRNA with combined analogues
Study
ratn: not reported in source
Prepubertal ovariectomized female rats
Comparator
Controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Pituitary gonadotropin subunit LHbeta mRNA levels were inhibited in all groups except controls
1 context sentence(design, population, supporting numbers)
Summary · context
To compare modes of action and effectiveness of GnRH analogues and assess treatment combinations of agonistic (triptorelin) and antagonistic (cetrorelix acetate) GnRH analogues with established treatment, we used prepubertal 31-d-old ovariectomized female rats.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1460525403
06AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In ovariectomized rats, combined triptorelin and cetrorelix did not affect pituitary GnRH receptor mRNA.
In plain wordsIn rats, combined triptorelin and cetrorelix did not affect pituitary GnRH receptor gene expression.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changePituitary GnRH receptor mRNA with combined analogues
Study
ratn: not reported in source
Prepubertal ovariectomized female rats
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
but pituitary GnRH receptor mRNA was stimulated by agonist yet unaffected by combined analogues.
1 context sentence(design, population, supporting numbers)
Summary · context
To compare modes of action and effectiveness of GnRH analogues and assess treatment combinations of agonistic (triptorelin) and antagonistic (cetrorelix acetate) GnRH analogues with established treatment, we used prepubertal 31-d-old ovariectomized female rats.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1460525405

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:35 UTC
Study data updated · source update from Europe PMC
Version 2
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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