Effects of cortistatin-14 and somatostatin-14 on the endocrine response to hexarelin in humans.

Benso A, Gottero C, Prodam F, Gauna C, Destefanis S, Filtri L, van der Lely AJ, Deghenghi R, Ghigo E, Broglio F

Journal of endocrinological investigation1 Jul 2003Cited by 10 (Europe PMC)

PMID14594107DOI10.1007/bf03347014PepBankPUB-14594107

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

3 results from studies that gave the peptide. 3 results from people.

01HumanNon-randomized trialEfficacy outcome
In 6 normal volunteers, intravenous hexarelin significantly increased prolactin levels.
In plain wordsIn 6 healthy volunteers, hexarelin raised prolactin levels.
Peptide
Hexarelin
Outcome
IncreaseProlactin response to hexarelin
Study
n = 6
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
1.0 microg/kg · i.v.As given in this study (human).
Source sentences
Summary
HEX significantly increased PRL, ACTH and cortisol levels but these responses were not modified by either CST-14 or SS-14.
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effects of CST-14 and SS-14 (2.0 microg/kg/h i.v. from -30 to +90 min) on the endocrine response to hexarelin (HEX, 1.0 microg/kg i.v. at 0 min), a synthetic GHS, in 6 normal volunteers [age (mean+/-SEM): 28.7+/-2.9 yr; body mass index: 23.4+/-0.8 kg/m2].
Report a problemFND-1459410703
02HumanNon-randomized trialEfficacy outcome
In 6 normal volunteers, intravenous hexarelin significantly increased ACTH levels.
In plain wordsIn 6 healthy volunteers, hexarelin raised ACTH levels.
Peptide
Hexarelin
Outcome
IncreaseACTH response to hexarelin
Study
n = 6
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
1.0 microg/kg · i.v.As given in this study (human).
Source sentences
Summary
HEX significantly increased PRL, ACTH and cortisol levels but these responses were not modified by either CST-14 or SS-14.
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effects of CST-14 and SS-14 (2.0 microg/kg/h i.v. from -30 to +90 min) on the endocrine response to hexarelin (HEX, 1.0 microg/kg i.v. at 0 min), a synthetic GHS, in 6 normal volunteers [age (mean+/-SEM): 28.7+/-2.9 yr; body mass index: 23.4+/-0.8 kg/m2].
Report a problemFND-1459410704
03HumanNon-randomized trialEfficacy outcome
In 6 normal volunteers, intravenous hexarelin significantly increased cortisol levels.
In plain wordsIn 6 healthy volunteers, hexarelin raised cortisol levels.
Peptide
Hexarelin
Outcome
IncreaseCortisol response to hexarelin
Study
n = 6
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
1.0 microg/kg · i.v.As given in this study (human).
Source sentences
Summary
HEX significantly increased PRL, ACTH and cortisol levels but these responses were not modified by either CST-14 or SS-14.
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effects of CST-14 and SS-14 (2.0 microg/kg/h i.v. from -30 to +90 min) on the endocrine response to hexarelin (HEX, 1.0 microg/kg i.v. at 0 min), a synthetic GHS, in 6 normal volunteers [age (mean+/-SEM): 28.7+/-2.9 yr; body mass index: 23.4+/-0.8 kg/m2].
Report a problemFND-1459410705

Studies that did not test the peptide alone4

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

04HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In 6 normal volunteers, cortistatin-14 infusion inhibited the growth hormone response to hexarelin.
In plain wordsIn 6 healthy volunteers, cortistatin-14 reduced the growth hormone rise that hexarelin caused.
Peptide
Hexarelin
Outcome
DecreaseGH response to hexarelin during cortistatin-14 infusion
Study
n = 6
Comparator
Hexarelin alone, without CST-14 infusion
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
3814.1 microg/l/h
hexarelin alone
GH AUC
1212.9 microg/l/h
hexarelin with CST-14
Source sentences
Summary
The GH response to HEX was similarly inhibited by either CST-14 (AUC: 3814.1+/-924.2 vs 1212.9+/-379.8 microg/l/h, p<0.05) or SS-14 (720.9+/-158.6 microg/l/h, p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effects of CST-14 and SS-14 (2.0 microg/kg/h i.v. from -30 to +90 min) on the endocrine response to hexarelin (HEX, 1.0 microg/kg i.v. at 0 min), a synthetic GHS, in 6 normal volunteers [age (mean+/-SEM): 28.7+/-2.9 yr; body mass index: 23.4+/-0.8 kg/m2].
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-1459410701
05HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In 6 normal volunteers, somatostatin-14 infusion inhibited the growth hormone response to hexarelin.
In plain wordsIn 6 healthy volunteers, somatostatin-14 reduced the growth hormone rise that hexarelin caused.
Peptide
Hexarelin
Outcome
DecreaseGH response to hexarelin during somatostatin-14 infusion
Study
n = 6
Comparator
Hexarelin alone, without SS-14 infusion
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
720.9 microg/l/h
hexarelin with SS-14
Source sentences
Summary
The GH response to HEX was similarly inhibited by either CST-14 (AUC: 3814.1+/-924.2 vs 1212.9+/-379.8 microg/l/h, p<0.05) or SS-14 (720.9+/-158.6 microg/l/h, p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effects of CST-14 and SS-14 (2.0 microg/kg/h i.v. from -30 to +90 min) on the endocrine response to hexarelin (HEX, 1.0 microg/kg i.v. at 0 min), a synthetic GHS, in 6 normal volunteers [age (mean+/-SEM): 28.7+/-2.9 yr; body mass index: 23.4+/-0.8 kg/m2].
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-1459410702
06HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In 6 normal volunteers, neither cortistatin-14 nor somatostatin-14 modified the hexarelin-induced rises in prolactin, ACTH and cortisol.
In plain wordsIn 6 healthy volunteers, cortistatin-14 and somatostatin-14 did not change the prolactin, ACTH and cortisol rises that hexarelin caused.
Peptide
Hexarelin
Outcome
No significant changeHexarelin PRL, ACTH and cortisol responses during CST-14 or SS-14
Study
n = 6
Comparator
Hexarelin alone, without CST-14 or SS-14 infusion
Outcome group
Pituitary hormones · Endocrine and hormones
Source sentences
Summary
HEX significantly increased PRL, ACTH and cortisol levels but these responses were not modified by either CST-14 or SS-14.
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effects of CST-14 and SS-14 (2.0 microg/kg/h i.v. from -30 to +90 min) on the endocrine response to hexarelin (HEX, 1.0 microg/kg i.v. at 0 min), a synthetic GHS, in 6 normal volunteers [age (mean+/-SEM): 28.7+/-2.9 yr; body mass index: 23.4+/-0.8 kg/m2].
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-1459410706
07HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In 6 normal volunteers, hexarelin did not modify the effects of cortistatin-14 and somatostatin-14 on insulin and glucose levels.
In plain wordsIn 6 healthy volunteers, hexarelin did not change how cortistatin-14 and somatostatin-14 affected insulin and glucose.
Peptide
Hexarelin
Outcome
No significant changeCST-14 and SS-14 effects on insulin and glucose with hexarelin
Study
n = 6
Outcome group
Glycemic control · Endocrine and hormones
Source sentences
Summary
The effects of CST-14 and SS-14 on insulin and glucose levels were not modified by HEX.
1 context sentence(design, population, supporting numbers)
Summary · context
We compared the effects of CST-14 and SS-14 (2.0 microg/kg/h i.v. from -30 to +90 min) on the endocrine response to hexarelin (HEX, 1.0 microg/kg i.v. at 0 min), a synthetic GHS, in 6 normal volunteers [age (mean+/-SEM): 28.7+/-2.9 yr; body mass index: 23.4+/-0.8 kg/m2].
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-1459410707

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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