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Study · In vitro (cells) · bovine · 2004

3 results

Agouti-related protein antagonizes glucocorticoid production induced through melanocortin 4 receptor activation in bovine adrenal cells: a possible autocrine control.

Doghman M, Delagrange P, Blondet A, Berthelon MC, Durand P, Naville D, Bégeot M

Endocrinology30 Oct 2003Cited by 30 (Europe PMC)

PMID14592963 (opens in a new tab)DOI10.1210/en.2003-0605 (opens in a new tab)PepBankPUB-14592963
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured bovine fasciculata adrenal cells, NDP-alphaMSH stimulated cortisol production in a dose-dependent manner.

    In plain wordsIn cultured cow adrenal cells, NDP-alphaMSH raised cortisol production, and more peptide gave more cortisol.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseCortisol production
    Study

    bovinen: not reported in source

    cultured fasciculata adrenal cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    (Nle4, d-Phe7)-alphaMSH (NDP-alphaMSH) stimulated the production of cortisol in a dose-dependent manner
    1 context sentence
    Summary · context
    Nevertheless, using cultured bovine fasciculata adrenal cells, we report that Agrp has no antagonistic properties against ACTH at the level of MC2-R.
  2. 02LabIn vitro (cells)Mechanism

    In cultured bovine fasciculata adrenal cells, antagonist and RT-PCR data suggested that the effects of NDP-alphaMSH were mediated via MC4-R.

    In plain wordsIn cultured cow adrenal cells, the data suggest that NDP-alphaMSH acts through the MC4 receptor.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableReceptor mediating NDP-alphaMSH effect on cortisol
    Study

    bovinen: not reported in source

    cultured fasciculata adrenal cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Using a more specific antagonist (JKC-363) and RT-PCR analysis, we can postulate that the effects of NDP-alphaMSH were mediated via MC4-R.
    1 context sentence
    Summary · context
    Nevertheless, using cultured bovine fasciculata adrenal cells, we report that Agrp has no antagonistic properties against ACTH at the level of MC2-R.

Studies that did not test the peptide alone1

In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan I (afamelanotide).

  1. 03LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cells)Mechanism

    In cultured bovine fasciculata adrenal cells, Agrp or SHU9119 abolished the cortisol production stimulated by NDP-alphaMSH.

    In plain wordsIn cultured cow adrenal cells, Agrp or SHU9119 blocked the extra cortisol that NDP-alphaMSH caused.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseNDP-alphaMSH-induced cortisol production with Agrp or SHU9119
    Study

    bovinen: not reported in source

    cultured fasciculata adrenal cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    these effects were abolished by Agrp or SHU9119, a synthetic antagonist of MC3-R and MC4-R.
    1 context sentence
    Summary · context
    Nevertheless, using cultured bovine fasciculata adrenal cells, we report that Agrp has no antagonistic properties against ACTH at the level of MC2-R.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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