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Study · In vitro (cells) · 2004

6 results

Thymosin beta 4 induces the synthesis of plasminogen activator inhibitor 1 in cultured endothelial cells and increases its extracellular expression.

Al-Nedawi KN, Czyz M, Bednarek R, Szemraj J, Swiatkowska M, Cierniewska-Cieslak A, Wyczolkowska J, Cierniewski CS

Blood30 Oct 2003Cited by 34 (Europe PMC)

PMID14592829 (opens in a new tab)DOI10.1182/blood-2003-04-1015 (opens in a new tab)PepBankPUB-14592829
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    Thymosin beta‑4 upregulated plasminogen activator inhibitor 1 (PAI-1) mRNA in endothelial cells.

    In plain wordsIn cultured endothelial cells, thymosin beta‑4 raised PAI-1 mRNA.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePAI-1 mRNA expression
    Study

    n: not reported in source

    cultured endothelial cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We have found that T beta 4 upregulates the expression of plasminogen activator inhibitor 1 (PAI-1) in endothelial cells measured both at the level of mRNA and protein synthesis.
  2. 02LabIn vitro (cells)Mechanism

    Thymosin beta‑4 upregulated plasminogen activator inhibitor 1 (PAI-1) protein synthesis in endothelial cells.

    In plain wordsIn cultured endothelial cells, thymosin beta‑4 raised PAI-1 protein production.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePAI-1 protein synthesis
    Study

    n: not reported in source

    cultured endothelial cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We have found that T beta 4 upregulates the expression of plasminogen activator inhibitor 1 (PAI-1) in endothelial cells measured both at the level of mRNA and protein synthesis.
  3. 03LabIn vitro (cells)Mechanism

    Thymosin beta‑4 did not upregulate PAI-1 in human fibroblasts, PC3 or U937 cells.

    In plain wordsIn lab tests, thymosin beta‑4 did not raise PAI-1 in fibroblasts, PC3 cells or U937 cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changePAI-1 expression in other cell types
    Study

    n: not reported in source

    human fibroblasts, PC3 and U937 cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This effect seems to be cell specific and was not observed when other cells such as human fibroblasts, PC3, and U937 were tested.
  4. 04LabIn vitro (cells)Mechanism

    Thymosin beta‑4 significantly activated the PAI-1 promoter in EA.hy 926 cells.

    In plain wordsIn EA.hy 926 cells, thymosin beta‑4 switched on the PAI-1 promoter.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePAI-1 promoter activation
    Study

    n: not reported in source

    EA.hy 926 endothelial cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    T beta 4 significantly activated the PAI-1 promoter in EA.hy 926 cells transiently transfected either with plasmid p800LUC containing PAI-1 promoter fragment (-800 to +71) or the PAI-1 promoter linked with green fluorescent protein.
  5. 05LabIn vitro (cells)Mechanism

    Thymosin beta‑4 upregulated PAI-1 through activation of the mitogen-activated protein kinase cascade.

    In plain wordsIn endothelial cells, thymosin beta‑4 raised PAI-1 through the mitogen-activated protein kinase pathway.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMitogen-activated protein kinase cascade activation
    Study

    n: not reported in source

    endothelial cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    T beta 4 mediated up-regulation of PAI-1 involved activation of the mitogen-activated protein kinase cascade.
  6. 06LabIn vitro (cells)Mechanism

    Thymosin beta‑4 enhanced c-Fos/c-Jun DNA-binding activity to the activator protein 1 (AP-1)-like element.

    In plain wordsIn endothelial cells, thymosin beta‑4 increased the binding of c-Fos/c-Jun to an AP-1-like DNA element.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Increasec-Fos/c-Jun DNA-binding activity to the AP-1-like element
    Study

    n: not reported in source

    endothelial cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, T beta 4 enhanced c-Fos/c-Jun DNA-binding activity to the activator protein 1 (AP-1)-like element (-59 to -52).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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