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Study · Animal study (in vivo) · rat · 2003

15 results

Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth.

Staresinic M, Sebecic B, Patrlj L, Jadrijevic S, Suknaic S, Perovic D, Aralica G, Zarkovic N, Borovic S, Srdjak M, Hajdarevic K, Kopljar M and 6 more

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Batelja L, Boban-Blagaic A, Turcic I, Anic T, Seiwerth S, Sikiric P

Journal of orthopaedic research : official publication of the Orthopaedic Research Society1 Nov 2003Cited by 53 (Europe PMC)

PMID14554208 (opens in a new tab)DOI10.1016/s0736-0266(03)00110-4 (opens in a new tab)PepBankPUB-14554208
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected Achilles tendons, BPC‑157 increased the load of failure compared with saline controls.

    In plain wordsIn rats with cut Achilles tendons, BPC‑157 made the tendon able to bear more load than saline.

    Peptide
    BPC-157
    Outcome
    IncreaseLoad of failure
    Study

    ratn: not reported in source

    Transected Achilles tendon
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg, 10 ng or 10 pg/kg · intraperitoneal · daily, assessed up to day 14As given in this study (rat).

    Source sentences

    Summary
    increased load of failure, load of failure per area and Young's modulus of elasticity
    2 context sentences
    Summary · context
    In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends.
    Summary · context
    Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected Achilles tendons, BPC‑157 increased the load of failure per area compared with saline controls.

    In plain wordsIn rats with cut Achilles tendons, BPC‑157 raised the load per area the tendon could bear, compared with saline.

    Peptide
    BPC-157
    Outcome
    IncreaseLoad of failure per area
    Study

    ratn: not reported in source

    Transected Achilles tendon
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg, 10 ng or 10 pg/kg · intraperitoneal · daily, assessed up to day 14As given in this study (rat).

    Source sentences

    Summary
    increased load of failure, load of failure per area and Young's modulus of elasticity
    2 context sentences
    Summary · context
    In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends.
    Summary · context
    Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected Achilles tendons, BPC‑157 increased Young's modulus of elasticity compared with saline controls.

    In plain wordsIn rats with cut Achilles tendons, BPC‑157 raised tendon stiffness compared with saline.

    Peptide
    BPC-157
    Outcome
    IncreaseYoung's modulus of elasticity
    Study

    ratn: not reported in source

    Transected Achilles tendon
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg, 10 ng or 10 pg/kg · intraperitoneal · daily, assessed up to day 14As given in this study (rat).

    Source sentences

    Summary
    increased load of failure, load of failure per area and Young's modulus of elasticity
    2 context sentences
    Summary · context
    In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends.
    Summary · context
    Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected Achilles tendons, BPC‑157 gave significantly higher Achilles functional index values than saline.

    In plain wordsIn rats with cut Achilles tendons, BPC‑157 gave better walking function scores than saline.

    Peptide
    BPC-157
    Outcome
    IncreaseAchilles functional index (AFI)
    Study

    ratn: not reported in source

    Transected Achilles tendon
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg, 10 ng or 10 pg/kg · intraperitoneal · daily, assessed up to day 14As given in this study (rat).

    Source sentences

    Summary
    significantly higher AFI-values
    2 context sentences
    Summary · context
    In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends.
    Summary · context
    Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected Achilles tendons, BPC‑157 gave more mononuclear cells on microscopy than saline.

    In plain wordsIn rats with cut Achilles tendons, BPC‑157 gave more mononuclear cells in the healing tendon than saline.

    Peptide
    BPC-157
    Outcome
    IncreaseMononuclear cells in healing tendon
    Study

    ratn: not reported in source

    Transected Achilles tendon
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg, 10 ng or 10 pg/kg · intraperitoneal · daily, assessed up to day 14As given in this study (rat).

    Source sentences

    Summary
    more mononuclears and less granulocytes
    2 context sentences
    Summary · context
    In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends.
    Summary · context
    Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected Achilles tendons, BPC‑157 gave fewer granulocytes on microscopy than saline.

    In plain wordsIn rats with cut Achilles tendons, BPC‑157 gave fewer granulocytes in the healing tendon than saline.

    Peptide
    BPC-157
    Outcome
    DecreaseGranulocytes in healing tendon
    Study

    ratn: not reported in source

    Transected Achilles tendon
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg, 10 ng or 10 pg/kg · intraperitoneal · daily, assessed up to day 14As given in this study (rat).

    Source sentences

    Summary
    more mononuclears and less granulocytes
    2 context sentences
    Summary · context
    In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends.
    Summary · context
    Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected Achilles tendons, BPC‑157 gave superior formation of fibroblasts on microscopy compared with saline.

    In plain wordsIn rats with cut Achilles tendons, BPC‑157 gave better fibroblast formation than saline.

    Peptide
    BPC-157
    Outcome
    IncreaseFibroblast formation
    Study

    ratn: not reported in source

    Transected Achilles tendon
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg, 10 ng or 10 pg/kg · intraperitoneal · daily, assessed up to day 14As given in this study (rat).

    Source sentences

    Summary
    superior formation of fibroblasts, reticulin and collagen
    2 context sentences
    Summary · context
    In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends.
    Summary · context
    Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected Achilles tendons, BPC‑157 gave superior formation of reticulin on microscopy compared with saline.

    In plain wordsIn rats with cut Achilles tendons, BPC‑157 gave better reticulin formation than saline.

    Peptide
    BPC-157
    Outcome
    IncreaseReticulin formation
    Study

    ratn: not reported in source

    Transected Achilles tendon
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg, 10 ng or 10 pg/kg · intraperitoneal · daily, assessed up to day 14As given in this study (rat).

    Source sentences

    Summary
    superior formation of fibroblasts, reticulin and collagen
    2 context sentences
    Summary · context
    In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends.
    Summary · context
    Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected Achilles tendons, BPC‑157 gave superior formation of collagen on microscopy compared with saline.

    In plain wordsIn rats with cut Achilles tendons, BPC‑157 gave better collagen formation than saline.

    Peptide
    BPC-157
    Outcome
    IncreaseCollagen formation
    Study

    ratn: not reported in source

    Transected Achilles tendon
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg, 10 ng or 10 pg/kg · intraperitoneal · daily, assessed up to day 14As given in this study (rat).

    Source sentences

    Summary
    superior formation of fibroblasts, reticulin and collagen
    2 context sentences
    Summary · context
    In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends.
    Summary · context
    Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected Achilles tendons, BPC‑157 gave a smaller macroscopic tendon defect size than saline.

    In plain wordsIn rats with cut Achilles tendons, BPC‑157 left a smaller tendon gap than saline.

    Peptide
    BPC-157
    Outcome
    DecreaseTendon defect size
    Study

    ratn: not reported in source

    Transected Achilles tendon
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg, 10 ng or 10 pg/kg · intraperitoneal · daily, assessed up to day 14As given in this study (rat).

    Source sentences

    Summary
    smaller size and depth of tendon defect
    2 context sentences
    Summary · context
    In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends.
    Summary · context
    Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected Achilles tendons, BPC‑157 gave a smaller macroscopic tendon defect depth than saline.

    In plain wordsIn rats with cut Achilles tendons, BPC‑157 left a shallower tendon gap than saline.

    Peptide
    BPC-157
    Outcome
    DecreaseTendon defect depth
    Study

    ratn: not reported in source

    Transected Achilles tendon
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg, 10 ng or 10 pg/kg · intraperitoneal · daily, assessed up to day 14As given in this study (rat).

    Source sentences

    Summary
    smaller size and depth of tendon defect
    2 context sentences
    Summary · context
    In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends.
    Summary · context
    Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transected Achilles tendons, BPC‑157 led to reestablishment of full tendon integrity on macroscopic assessment.

    In plain wordsIn rats with cut Achilles tendons, BPC‑157 led to full tendon integrity again, compared with saline controls.

    Peptide
    BPC-157
    Outcome
    IncreaseReestablishment of full tendon integrity
    Study

    ratn: not reported in source

    Transected Achilles tendon
    Comparator
    Saline
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    10 microg, 10 ng or 10 pg/kg · intraperitoneal · daily, assessed up to day 14As given in this study (rat).

    Source sentences

    Summary
    the reestablishment of full tendon integrity.
    2 context sentences
    Summary · context
    In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends.
    Summary · context
    Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy.
  13. 13LabIn vitro (cells)Efficacy outcome

    In cultured tendocytes, BPC‑157 had no effect on cell growth by itself, unlike TGF-beta.

    In plain wordsIn cells, BPC‑157 alone did not change tendon cell growth, unlike TGF-beta.

    Peptide
    BPC-157
    Outcome
    No significant changeGrowth of cultured tendocytes with BPC 157 alone
    Study

    n: not reported in source

    Cultured tendocytes
    Comparator
    TGF-beta
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    unlike TGF-beta, pentadecapeptide BPC 157, presenting with no effect on the growth of cultured cell of its own, consistently opposed 4-hydroxynonenal (HNE), a negative modulator of the growth.
  14. 14LabIn vitro (cells)Efficacy outcome

    In cultured tendocytes, with BPC‑157 plus HNE the HNE growth-inhibiting effect was reversed into growth stimulation, with and without serum.

    In plain wordsIn cells, BPC‑157 turned the growth-slowing effect of 4-hydroxynonenal into growth stimulation, with and without serum.

    Peptide
    BPC-157
    Outcome
    IncreaseBPC 157 plus HNE on tendocyte growth
    Study

    n: not reported in source

    Cultured tendocytes
    Comparator
    4-hydroxynonenal (HNE) alone
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157+HNE (HNE growth inhibiting effect reversed into growth stimulation of cultured tendocytes)
    1 context sentence
    Summary · context
    both in the presence of serum and serum deprived conditions.
  15. 15LabIn vitro (cells)Efficacy outcome

    In cultured tendocytes, with HNE then BPC‑157 the growth-inhibiting activity of the aldehyde was abolished, with and without serum.

    In plain wordsIn cells, BPC‑157 removed the growth-slowing effect of 4-hydroxynonenal, with and without serum.

    Peptide
    BPC-157
    Outcome
    IncreaseHNE plus BPC 157 on tendocyte growth
    Study

    n: not reported in source

    Cultured tendocytes
    Comparator
    4-hydroxynonenal (HNE) alone
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNE+BPC 157(abolished inhibiting activity of the aldehyde)
    1 context sentence
    Summary · context
    both in the presence of serum and serum deprived conditions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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