Peptides of pineal gland and thymus prolong human life.

Khavinson VKh, Morozov VG

Neuro endocrinology letters1 Jun 2003Cited by 6 (Europe PMC)

PMID14523363PepBankPUB-14523363

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

1 result from studies that gave the peptide. 1 result from people.

01HumanNon-randomized trialSafety outcome
In elderly and older people, mortality in the Thymalin-treated group was 2.0-2.1-fold lower than control during observation.
In plain wordsIn older people, mortality was 2.0-2.1-fold lower in the Thymalin group than control during observation.
Peptide
Thymalin
Outcome
DecreaseMortality with Thymalin
Study
n: not reported in source
Comparator
Control
Outcome group
Mortality · Whole body
Studied dose
Dose not stated · First 2-3 years of observationAs given in this study (human).
Measurements
Mortality reduction
2 to 2.1 fold
Thymalin versus control
Source sentences
Summary
Such a significant improvement in the health state of the peptide-treated patients correlated with decreased mortality rate during observation: 2.0-2.1-fold in the Thymalin-treated group; 1.6-1.8-fold in the Epithalamin-treated group; 2.5-fold in the patients treated with Thymalin plus Epithalamin a…
2 context sentences(design, population, supporting numbers)
Summary · context
clinically assessed the geroprotective effects of thymic (Thymalin) and pineal (Epithalamin) peptide bioregulators in 266 elderly and older persons during 6-8 years.
Summary · context
The bioregulators were applied for the first 2-3 years of observation.
Report a problemFND-1452336307

Studies that did not test the peptide alone8

In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymalin.

02HumanNot a test of Thymalin aloneNon-randomized trialEfficacy outcome
In older people, pooled thymic and pineal bioregulators improved general indices of cardiovascular, endocrine, immune and nervous systems, homeostasis and metabolism.
In plain wordsIn older people, pooled bioregulators including Thymalin improved general measures of body systems, homeostasis and metabolism.
Peptide
Thymalin
Outcome
IncreaseGeneral physiological indices
Study
n: not reported in source
Outcome group
Overall treatment effect · Whole body
Source sentences
Summary
The obtained results convincingly showed the ability of the bioregulators to normalize the basic functions of the human organism, i.e. to improve the indices of cardiovascular, endocrine, immune and nervous systems, homeostasis and metabolism.
2 context sentences(design, population, supporting numbers)
Summary · context
clinically assessed the geroprotective effects of thymic (Thymalin) and pineal (Epithalamin) peptide bioregulators in 266 elderly and older persons during 6-8 years.
Summary · context
The bioregulators were applied for the first 2-3 years of observation.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-1452336301
03HumanNot a test of Thymalin aloneNon-randomized trialEfficacy outcome
In elderly and older people, pooled bioregulator treatment accompanied a 2.0-2.4-fold reduction in acute respiratory disease incidence versus control.
In plain wordsIn older people, pooled bioregulators including Thymalin accompanied fewer acute respiratory diseases than control.
Peptide
Thymalin
Outcome
DecreaseAcute respiratory disease incidence
Study
n: not reported in source
Comparator
Control
Outcome group
Infection and antimicrobial activity · Respiratory
Measurements
Incidence reduction
2 to 2.4 fold
versus control
Source sentences
Summary
Homeostasis restoration was accompanied by a 2.0-2.4-fold decrease in acute respiratory disease incidence, reduced incidence of the clinical manifestations of ischemic heart disease, hypertension disease, deforming osteoarthrosis and osteoporosis as compared to the control.
2 context sentences(design, population, supporting numbers)
Summary · context
clinically assessed the geroprotective effects of thymic (Thymalin) and pineal (Epithalamin) peptide bioregulators in 266 elderly and older persons during 6-8 years.
Summary · context
The bioregulators were applied for the first 2-3 years of observation.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-1452336302
04HumanNot a test of Thymalin aloneNon-randomized trialEfficacy outcome
In elderly and older people, pooled bioregulator treatment accompanied fewer clinical manifestations of ischemic heart disease than control.
In plain wordsIn older people, pooled bioregulators including Thymalin accompanied fewer ischemic heart disease manifestations than control.
Peptide
Thymalin
Outcome
DecreaseIschemic heart disease clinical manifestations
Study
n: not reported in source
Comparator
Control
Outcome group
Cardiovascular events · Cardiovascular
Source sentences
Summary
Homeostasis restoration was accompanied by a 2.0-2.4-fold decrease in acute respiratory disease incidence, reduced incidence of the clinical manifestations of ischemic heart disease, hypertension disease, deforming osteoarthrosis and osteoporosis as compared to the control.
2 context sentences(design, population, supporting numbers)
Summary · context
clinically assessed the geroprotective effects of thymic (Thymalin) and pineal (Epithalamin) peptide bioregulators in 266 elderly and older persons during 6-8 years.
Summary · context
The bioregulators were applied for the first 2-3 years of observation.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-1452336303
05HumanNot a test of Thymalin aloneNon-randomized trialEfficacy outcome
In elderly and older people, pooled bioregulator treatment accompanied fewer clinical manifestations of hypertension disease than control.
In plain wordsIn older people, pooled bioregulators including Thymalin accompanied fewer hypertension disease manifestations than control.
Peptide
Thymalin
Outcome
DecreaseHypertension disease clinical manifestations
Study
n: not reported in source
Comparator
Control
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
Homeostasis restoration was accompanied by a 2.0-2.4-fold decrease in acute respiratory disease incidence, reduced incidence of the clinical manifestations of ischemic heart disease, hypertension disease, deforming osteoarthrosis and osteoporosis as compared to the control.
2 context sentences(design, population, supporting numbers)
Summary · context
clinically assessed the geroprotective effects of thymic (Thymalin) and pineal (Epithalamin) peptide bioregulators in 266 elderly and older persons during 6-8 years.
Summary · context
The bioregulators were applied for the first 2-3 years of observation.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-1452336304
06HumanNot a test of Thymalin aloneNon-randomized trialEfficacy outcome
In elderly and older people, pooled bioregulator treatment accompanied fewer clinical manifestations of deforming osteoarthrosis than control.
In plain wordsIn older people, pooled bioregulators including Thymalin accompanied fewer deforming osteoarthrosis manifestations than control.
Peptide
Thymalin
Outcome
DecreaseDeforming osteoarthrosis clinical manifestations
Study
n: not reported in source
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Homeostasis restoration was accompanied by a 2.0-2.4-fold decrease in acute respiratory disease incidence, reduced incidence of the clinical manifestations of ischemic heart disease, hypertension disease, deforming osteoarthrosis and osteoporosis as compared to the control.
2 context sentences(design, population, supporting numbers)
Summary · context
clinically assessed the geroprotective effects of thymic (Thymalin) and pineal (Epithalamin) peptide bioregulators in 266 elderly and older persons during 6-8 years.
Summary · context
The bioregulators were applied for the first 2-3 years of observation.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-1452336305
07HumanNot a test of Thymalin aloneNon-randomized trialEfficacy outcome
In elderly and older people, pooled bioregulator treatment accompanied fewer clinical manifestations of osteoporosis than control.
In plain wordsIn older people, pooled bioregulators including Thymalin accompanied fewer osteoporosis manifestations than control.
Peptide
Thymalin
Outcome
DecreaseOsteoporosis clinical manifestations
Study
n: not reported in source
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Homeostasis restoration was accompanied by a 2.0-2.4-fold decrease in acute respiratory disease incidence, reduced incidence of the clinical manifestations of ischemic heart disease, hypertension disease, deforming osteoarthrosis and osteoporosis as compared to the control.
2 context sentences(design, population, supporting numbers)
Summary · context
clinically assessed the geroprotective effects of thymic (Thymalin) and pineal (Epithalamin) peptide bioregulators in 266 elderly and older persons during 6-8 years.
Summary · context
The bioregulators were applied for the first 2-3 years of observation.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-1452336306
08HumanNot a test of Thymalin aloneNon-randomized trialSafety outcome
In elderly and older people, mortality with Thymalin plus Epithalamin was 2.5-fold lower than control during observation.
In plain wordsIn older people, mortality with Thymalin plus Epithalamin was 2.5-fold lower than control.
Peptide
Thymalin
Outcome
DecreaseMortality with Thymalin plus Epithalamin
Study
n: not reported in source
Comparator
Control
Outcome group
Mortality · Whole body
Measurements
Mortality reduction
2.5 fold
combination versus control
Source sentences
Summary
Such a significant improvement in the health state of the peptide-treated patients correlated with decreased mortality rate during observation: 2.0-2.1-fold in the Thymalin-treated group; 1.6-1.8-fold in the Epithalamin-treated group; 2.5-fold in the patients treated with Thymalin plus Epithalamin a…
2 context sentences(design, population, supporting numbers)
Summary · context
clinically assessed the geroprotective effects of thymic (Thymalin) and pineal (Epithalamin) peptide bioregulators in 266 elderly and older persons during 6-8 years.
Summary · context
The bioregulators were applied for the first 2-3 years of observation.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-1452336308
09HumanNot a test of Thymalin aloneNon-randomized trialSafety outcome
In elderly and older people, annual Thymalin with Epithalamin for 6 years accompanied mortality 4.1 times lower than control.
In plain wordsIn older people, annual Thymalin with Epithalamin for 6 years accompanied mortality 4.1 times lower than control.
Peptide
Thymalin
Outcome
DecreaseMortality with annual combination treatment
Study
n: not reported in source
Comparator
Control
Outcome group
Mortality · Whole body
Measurements
Mortality reduction
4.1 times
annual combination versus control
Source sentences
Summary
A separate group of patients was treated with Thymalin in combination with Epithalamin annually for 6 years and their mortality rate decreased 4.1 times as compared to the control.
2 context sentences(design, population, supporting numbers)
Summary · context
clinically assessed the geroprotective effects of thymic (Thymalin) and pineal (Epithalamin) peptide bioregulators in 266 elderly and older persons during 6-8 years.
Summary · context
The bioregulators were applied for the first 2-3 years of observation.
In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.
Report a problemFND-1452336309

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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