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Study · Ex vivo tissue · 1999

8 results

Thymosin beta4 enhances endothelial cell differentiation and angiogenesis.

Grant DS, Rose W, Yaen C, Goldstein A, Martinez J, Kleinman H

Angiogenesis1 Jan 1999Cited by 104 (Europe PMC)

PMID14517430 (opens in a new tab)DOI10.1023/a:1009041911493 (opens in a new tab)PepBankPUB-14517430
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In the coronary artery ring angiogenesis assay, exogenous thymosin beta4 enhanced vascular sprouting.

    In plain wordsIn lab tests on artery rings, added thymosin beta4 increased the sprouting of new vessels.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseVascular sprouting in coronary artery ring assay
    Study

    n: not reported in source

    coronary artery ring angiogenesis assay
    Outcome group
    Wound healing · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, exogenous thymosin beta4 enhances vascular sprouting in the coronary artery ring angiogenesis assay.
  2. 02LabEx vivo tissueActivity measurement

    In the coronary artery ring assay, as little as 100 ng of synthetic thymosin beta4 doubled the vessel area through increased branching.

    In plain wordsIn lab tests on artery rings, a small amount of synthetic thymosin beta4 doubled the vessel area.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseVessel area in coronary artery ring assay
    Study

    n: not reported in source

    coronary artery ring angiogenesis assay
    Outcome group
    Wound healing · Cardiovascular
    Studied dose
    100 ngAs given in this study.

    Source sentences

    Summary
    Measurements of these vascular sprouts show a doubling of the vessel area (via increased branching) with as little as 100 ng of synthetic thymosin beta4.
  3. 03LabIn vitro (cells)Activity measurement

    In HUVEC, exogenous thymosin beta4 increased tube formation in vitro.

    In plain wordsIn cells, added thymosin beta4 increased the formation of capillary-like tubes.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTube formation in vitro
    Study

    humann: not reported in source

    HUVEC
    Outcome group
    Wound healing · Cardiovascular
    Studied dose
    ng-microg rangeAs given in this study (human).

    Source sentences

    Summary
    These responses include increased tube formation in vitro.
    1 context sentence
    Summary · context
    We now show that exogenous addition of thymosin beta4 (in the ng-microg range) to HUVEC in culture can induce several biological responses.
  4. 04LabIn vitro (cells)Activity measurement

    In HUVEC, thymosin beta4 induced an increase in cell-matrix attachment.

    In plain wordsIn cells, thymosin beta4 increased how well the cells attached to their surroundings.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCell-matrix attachment
    Study

    humann: not reported in source

    HUVEC
    Outcome group
    Wound healing · Cardiovascular
    Studied dose
    ng-microg rangeAs given in this study (human).

    Source sentences

    Summary
    In summary Tbeta4 induces an increase in cell-matrix attachment, proliferation, tube formation, internalization of the peptide and rearrangement of the actin cytoskeleton.
    1 context sentence
    Summary · context
    We now show that exogenous addition of thymosin beta4 (in the ng-microg range) to HUVEC in culture can induce several biological responses.
  5. 05LabIn vitro (cells)Activity measurement

    In HUVEC, thymosin beta4 induced an increase in proliferation.

    In plain wordsIn cells, thymosin beta4 increased the growth in number of blood vessel cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseEndothelial cell proliferation
    Study

    humann: not reported in source

    HUVEC
    Outcome group
    Wound healing · Cardiovascular
    Studied dose
    ng-microg rangeAs given in this study (human).

    Source sentences

    Summary
    In summary Tbeta4 induces an increase in cell-matrix attachment, proliferation, tube formation, internalization of the peptide and rearrangement of the actin cytoskeleton.
    1 context sentence
    Summary · context
    We now show that exogenous addition of thymosin beta4 (in the ng-microg range) to HUVEC in culture can induce several biological responses.
  6. 06LabIn vitro (cells)Mechanism

    In HUVEC, thymosin beta4 induced rearrangement of the actin cytoskeleton.

    In plain wordsIn cells, thymosin beta4 changed the arrangement of the actin skeleton inside cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableActin cytoskeleton rearrangement
    Study

    humann: not reported in source

    HUVEC
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    ng-microg rangeAs given in this study (human).

    Source sentences

    Summary
    In summary Tbeta4 induces an increase in cell-matrix attachment, proliferation, tube formation, internalization of the peptide and rearrangement of the actin cytoskeleton.
    1 context sentence
    Summary · context
    We now show that exogenous addition of thymosin beta4 (in the ng-microg range) to HUVEC in culture can induce several biological responses.
  7. 07LabIn vitro (cells)Mechanism

    In HUVEC, thymosin beta4 was internalized, and cytoplasmic thymosin beta4 staining increased after exposure to 10 microg of the peptide without apparent increased mRNA translation.

    In plain wordsIn cells, added thymosin beta4 entered the cells and cytoplasmic staining rose.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePeptide internalization and cytoplasmic staining
    Study

    humann: not reported in source

    HUVEC
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    10 microgAs given in this study (human).

    Source sentences

    Summary
    These processes appear to involve the binding of thymosin beta4 to an unknown cell surface receptor and internalization of the protein.
    2 context sentences
    Summary · context
    An increase in thymosin beta4 cytoplasmic staining in HUVEC exposed 10 microg of the peptide appears to occur without increased mRNA translation.
    Summary · context
    We now show that exogenous addition of thymosin beta4 (in the ng-microg range) to HUVEC in culture can induce several biological responses.
  8. 08LabIn vitro (cells)Mechanism

    In HUVEC, cell surface binding of thymosin beta4 appeared not to be mediated through the actin-binding domain LKTET.

    In plain wordsIn cells, thymosin beta4 appeared to attach to the cell surface without using its actin-binding region.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCell surface binding not mediated by LKTET domain
    Study

    humann: not reported in source

    HUVEC
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    ng-microg rangeAs given in this study (human).

    Source sentences

    Summary
    This cell surface-binding appears not to be mediated through the thymosin beta4-actin binding domain LKTET.
    1 context sentence
    Summary · context
    We now show that exogenous addition of thymosin beta4 (in the ng-microg range) to HUVEC in culture can induce several biological responses.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

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