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Study · Animal study (in vivo) · rat · 2003

3 results

Different effect of antiulcer agents on rat cysteamine-induced duodenal ulcer after sialoadenectomy, but not gastrectomy.

Bedekovic V, Mise S, Anic T, Staresinic M, Gjurasin M, Kopljar M, Kalogjera L, Drvis P, Boban Blagaic A, Batelja L, Seiwerth S, Sikiric P

European journal of pharmacology1 Sept 2003Cited by 12 (Europe PMC)

PMID14512101 (opens in a new tab)DOI10.1016/j.ejphar.2003.08.013 (opens in a new tab)PepBankPUB-14512101
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In normal rats, BPC‑157 inhibited cysteamine-induced duodenal ulcers through gastric acid-independent mechanisms.

    In plain wordsIn normal rats, BPC‑157 reduced duodenal ulcers caused by cysteamine.

    Peptide
    BPC-157
    Outcome
    DecreaseCysteamine duodenal ulcer in normal rats
    Study

    ratn: not reported in source

    cysteamine-induced duodenal ulcer
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    in normal or gastrectomized rats all agents tested, gastric pentadecapeptide BPC 157 [currently in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) (10.0 microg or 10.0 ng), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)] inhibited cysteamine-induced duodenal ulcers
    1 context sentence
    Summary · context
    We tested antiulcer agents on cysteamine-induced duodenal ulcer in rats (agents/kg i.p.) simultaneously with cysteamine 400 mg/kg s.c., rat killed 24 h thereafter subjected to no surgery (normal), to gastrectomy (24 h before) or sialoadenectomy, acute (24 h before) or chronic (21 days before).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In gastrectomized rats, BPC‑157 inhibited cysteamine-induced duodenal ulcers through gastric acid-independent mechanisms.

    In plain wordsIn rats with the stomach removed, BPC‑157 reduced duodenal ulcers caused by cysteamine.

    Peptide
    BPC-157
    Outcome
    DecreaseCysteamine duodenal ulcer in gastrectomized rats
    Study

    ratn: not reported in source

    cysteamine-induced duodenal ulcer
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    in normal or gastrectomized rats all agents tested, gastric pentadecapeptide BPC 157 [currently in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) (10.0 microg or 10.0 ng), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)] inhibited cysteamine-induced duodenal ulcers
    1 context sentence
    Summary · context
    We tested antiulcer agents on cysteamine-induced duodenal ulcer in rats (agents/kg i.p.) simultaneously with cysteamine 400 mg/kg s.c., rat killed 24 h thereafter subjected to no surgery (normal), to gastrectomy (24 h before) or sialoadenectomy, acute (24 h before) or chronic (21 days before).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats after acute or chronic sialoadenectomy, BPC‑157 could protect against cysteamine-induced duodenal ulcer, while ranitidine, omeprazole and atropine were ineffective.

    In plain wordsIn rats with the salivary glands removed, BPC‑157 protected against duodenal ulcers while standard ulcer drugs did not.

    Peptide
    BPC-157
    Outcome
    DecreaseCysteamine duodenal ulcer after sialoadenectomy
    Study

    ratn: not reported in source

    cysteamine-induced duodenal ulcer
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Following sialoadenectomy, acute or chronic: ranitidine, omeprazole and atropine were completely ineffective, while pentadecapeptide BPC 157 could protect.
    1 context sentence
    Summary · context
    We tested antiulcer agents on cysteamine-induced duodenal ulcer in rats (agents/kg i.p.) simultaneously with cysteamine 400 mg/kg s.c., rat killed 24 h thereafter subjected to no surgery (normal), to gastrectomy (24 h before) or sialoadenectomy, acute (24 h before) or chronic (21 days before).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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