In goldfish, intracerebroventricular NDP-alpha-MSH, a universal melanocortin agonist, dose-dependently inhibited food intake 2 h after treatment.
In plain wordsIn goldfish, NDP-alpha-MSH given into the brain reduced food intake in a dose-dependent way.
- Peptide
- Melanotan I (afamelanotide)
- Outcome
- DecreaseFood intake 2 h after treatment
- Study
goldfishn: not reported in source
in vivo, whole animal- Outcome group
- Appetite and food intake · Metabolic and weight
- Studied dose
- nanomolar range · intracerebroventricularAs given in this study (goldfish).
Source sentences
Intracerebroventricular administration of [Nle(4), D-Phe(7)]-alpha-MSH (NDP-alpha-MSH), a universal melanocortin agonist, within nanomolar range, dose-dependently inhibited food intake 2 h after treatment.
1 context sentence(design, population, supporting numbers)
We studied the involvement of the central melanocortin system in the control of food intake in the goldfish.