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Study · Ex vivo tissue · guinea pig · 2003

3 results

Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin.

Bedendi I, Alloatti G, Marcantoni A, Malan D, Catapano F, Ghé C, Deghenghi R, Ghigo E, Muccioli G

European journal of pharmacology1 Aug 2003Cited by 122 (Europe PMC)

PMID12969753 (opens in a new tab)DOI10.1016/s0014-2999(03)02083-1 (opens in a new tab)PepBankPUB-12969753
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In guinea pig papillary muscle, hexarelin reduced the tension developed at low stimulation frequencies in a dose-dependent manner.

    In plain wordsIn guinea pig heart muscle, hexarelin lowered contraction strength at low beat rates.

    Peptide
    Hexarelin
    Outcome
    DecreasePapillary muscle tension at low frequencies
    Study

    guinea pign: not reported in source

    Guinea pig papillary muscle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1 microMAs given in this study (guinea pig).

    Source sentences

    Summary
    We observed that all peptides reduced the tension developed at low frequencies (60-120 beats/min) in a dose-dependent manner.
    1 context sentence
    Summary · context
    In order to clarify these aspects, we studied the effects of either the synthetic peptidyl GHS hexarelin (1 microM), or the natural ghrelin (50 nM) and the endogenous ghrelin derivatives des-Gln14-ghrelin (1-100 nM) and des-octanoyl ghrelin (50 nM), on the tension developed by guinea pig papillary m…
  2. 02LabEx vivo tissueActivity measurement

    In guinea pig papillary muscle, hexarelin was the least potent of the tested peptides on tension, below des-octanoyl ghrelin, ghrelin and des-Gln14-ghrelin.

    In plain wordsIn guinea pig heart muscle, hexarelin was weaker than the ghrelin forms at lowering contraction strength.

    Peptide
    Hexarelin
    Outcome
    Not applicablePotency on papillary muscle tension relative to ghrelin forms
    Study

    guinea pign: not reported in source

    Papillary muscle and ventricular cell membranes
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1 microMAs given in this study (guinea pig).

    Source sentences

    Summary
    The order of potency on the tension of papillary muscle was: des-octanoyl ghrelin > ghrelin = des-Gln14-ghrelin > hexarelin.
    1 context sentence
    Summary · context
    In order to clarify these aspects, we studied the effects of either the synthetic peptidyl GHS hexarelin (1 microM), or the natural ghrelin (50 nM) and the endogenous ghrelin derivatives des-Gln14-ghrelin (1-100 nM) and des-octanoyl ghrelin (50 nM), on the tension developed by guinea pig papillary m…
  3. 03LabEx vivo tissueMechanism

    In guinea pig ventricular membranes, hexarelin recognized a common high-affinity binding site shared with ghrelin forms.

    In plain wordsIn guinea pig heart membranes, hexarelin attached to the same strong binding site as the ghrelin forms.

    Peptide
    Hexarelin
    Outcome
    Not applicableBinding to ventricular membranes
    Study

    guinea pign: not reported in source

    Guinea pig ventricular cell membranes
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This gradient of potency was consistent with the binding experiments performed on ventricular membranes where either acylated or unacylated ghrelin forms, and hexarelin, recognized a common high-affinity binding site.
    1 context sentence
    Summary · context
    In order to clarify these aspects, we studied the effects of either the synthetic peptidyl GHS hexarelin (1 microM), or the natural ghrelin (50 nM) and the endogenous ghrelin derivatives des-Gln14-ghrelin (1-100 nM) and des-octanoyl ghrelin (50 nM), on the tension developed by guinea pig papillary m…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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