In neuronal hybrid cells expressing p75NTR, Humanin inhibited Abeta neurotoxicity that acts through p75NTR.
In plain wordsIn cells, Humanin reduced the toxic effect of amyloid-beta that acts through the p75 receptor.
- Peptide
- Humanin
- Outcome
- DecreaseAbeta neurotoxicity via p75NTR
- Study
n: not reported in source
neuronal hybrid cells transfected with p75NTR- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- Dose not stated
Source sentences
Further investigation suggested that Abeta neurotoxicity via p75NTR involved JNK, NADPH oxidase, and caspases-9/3 and was inhibited by activity-dependent neurotrophic factor, insulin-like growth factor-I, basic fibroblast growth factor, and Humanin, as observed in primary neuron cultures.
1 context sentence(design, population, supporting numbers)
Here we report that Abeta causes cell death in neuronal hybrid cells transfected with p75NTR, but not in nontransfected cells, and that p75NTR(L401K) cannot mediate Abeta neurotoxicity.