In Fmoc solid phase synthesis on four trityl-type amidomethyl polystyrene resins, pure thymosin beta‑4 was obtained with a yield of approximately 30% from each resin.
In plain wordsIn lab chemistry, four types of resin each gave about 30% yield of pure thymosin beta‑4.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- Not applicableYield of synthetic thymosin beta-4 from four trityl-type resins
- Study
n: not reported in source
Fmoc solid phase peptide synthesis on trityl-type amidomethyl polystyrene resins- Outcome group
- Synthesis and manufacturing · Pharmacology
Measurements
- Final yield
- ≈ 30%
- each resin
Source sentences
Independent of their differences in acid sensitivity, the resins seemed to function equally well under the conditions used, since pure thymosin beta-4 was obtained with a final yield of approximately 30% from each resin.
1 context sentence(design, population, supporting numbers)
The above resins were applied, in parallel with Wang benzyl-type resin, well known for its stability in mild acidic conditions, to the Fmoc solid phase synthesis of the 43-amino acid residue long bioactive peptide thymosin beta-4.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).