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Study · Not a test of the peptide alone · 2003

3 results

Congenital methemoglobinemia: a rare cause of cyanosis in the newborn--a case report.

Da-Silva SS, Sajan IS, Underwood JP 3rd

Pediatrics1 Aug 2003Cited by 57 (Europe PMC)

PMID12897322 (opens in a new tab)DOI10.1542/peds.112.2.e158 (opens in a new tab)PepBankPUB-12897322
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Methylene blue was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Methylene blue.

  1. 01HumanNot a test of Methylene blue aloneCase report or seriesEfficacy outcome

    In an infant with congenital reductase deficiency, daily methylene blue plus ascorbic acid produced a reported very good response.

    In plain wordsIn an infant with congenital enzyme deficiency, daily methylene blue plus ascorbic acid produced a reported very good response.

    Peptide
    Methylene blue
    Outcome
    Not applicableClinical response
    Study

    n = 1

    Outcome group
    Overall treatment effect · Whole body

    Source sentences

    Summary
    He responded very well to daily methylene blue and ascorbic acid administration
    2 context sentences
    Summary · context
    We present a neonate with cyanosis as a result of congenital deficiency of the reduced nicotinamide adenine dinucleotide-cytochrome b5 reductase enzyme.
    Summary · context
    Red blood cell enzyme activity and DNA analysis revealed a homozygous form of the cytochrome b5 reductase enzyme deficiency.

    In this study, Methylene blue was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Methylene blue.

  2. 02HumanNot a test of Methylene blue aloneCase report or seriesEfficacy outcome

    An infant receiving methylene blue plus ascorbic acid for congenital reductase deficiency had normal growth and developmental parameters.

    In plain wordsAn infant receiving methylene blue plus ascorbic acid for congenital enzyme deficiency had normal growth and development.

    Peptide
    Methylene blue
    Outcome
    Not applicableGrowth and developmental parameters
    Study

    n = 1

    Outcome group
    Linear growth · Whole body

    Source sentences

    Summary
    He responded very well to daily methylene blue and ascorbic acid administration, and he has normal growth and developmental parameters
    2 context sentences
    Summary · context
    We present a neonate with cyanosis as a result of congenital deficiency of the reduced nicotinamide adenine dinucleotide-cytochrome b5 reductase enzyme.
    Summary · context
    Red blood cell enzyme activity and DNA analysis revealed a homozygous form of the cytochrome b5 reductase enzyme deficiency.

    In this study, Methylene blue was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Methylene blue.

  3. 03HumanNot a test of Methylene blue aloneCase report or seriesEfficacy outcome

    An infant receiving methylene blue plus ascorbic acid still showed exaggerated methemoglobin increases with minor oxidant stress such as diarrhea.

    In plain wordsAn infant receiving methylene blue plus ascorbic acid still had exaggerated methemoglobin increases during minor oxidant stress, such as diarrhea.

    Peptide
    Methylene blue
    Outcome
    IncreaseMethemoglobin response to oxidant stress
    Study

    n = 1

    Outcome group
    Blood oxygenation and oxygen transport · Whole body

    Source sentences

    Summary
    although he shows an exaggerated increase in his methemoglobin level with minor oxidant stress such as diarrhea.
    2 context sentences
    Summary · context
    We present a neonate with cyanosis as a result of congenital deficiency of the reduced nicotinamide adenine dinucleotide-cytochrome b5 reductase enzyme.
    Summary · context
    Red blood cell enzyme activity and DNA analysis revealed a homozygous form of the cytochrome b5 reductase enzyme deficiency.

    In this study, Methylene blue was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Methylene blue.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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