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Study · In vitro (cell-free) · 2003

4 results

Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Abeta(1-40).

Zou P, Ding Y, Sha Y, Hu B, Nie S

Peptides1 May 2003Cited by 25 (Europe PMC)

PMID12895653 (opens in a new tab)DOI10.1016/s0196-9781(03)00131-1 (opens in a new tab)PepBankPUB-12895653
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Mechanism

    In aggregation assays, the interaction of humanin with Abeta(1-40) induced a quick and significant increase of light-scattering intensity.

    In plain wordsIn lab tests, humanin mixed with amyloid beta quickly raised light scattering, a sign of changed aggregation.

    Peptide
    Humanin
    Outcome
    IncreaseLight-scattering intensity of Abeta(1-40) with HN
    Study

    n: not reported in source

    Abeta(1-40) aggregation assay
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the interactions of both HN and HNG with Abeta(1-40) induced quick and significant increase of light-scattering intensity

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 02LabNot a test of Humanin aloneIn vitro (cells)Activity measurement

    In cultured neurons, the interaction of the humanin analogue HNG with Abeta(1-40) decreased the Abeta(1-40)-induced calcium rise.

    In plain wordsIn rat brain cells in a dish, a humanin analogue lowered the calcium rise caused by amyloid beta.

    Peptide
    Humanin
    Outcome
    DecreaseAbeta(1-40)-induced calcium rise with HNG
    Study

    ratn: not reported in source

    cultured rat hippocampal neurons
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    In the meantime, the experiments also revealed that the interaction of HNG with Abeta(1-40) could decrease Abeta(1-40)-induced calcium rise, an initial event accompanying Abeta(1-40)-induced apoptosis of cultured neurons.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 03LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    In aggregation assays, the interaction of the humanin analogue HNG with Abeta(1-40) induced a quick and significant increase of light-scattering intensity.

    In plain wordsIn lab tests, a humanin analogue mixed with amyloid beta quickly raised light scattering, a sign of changed aggregation.

    Peptide
    Humanin
    Outcome
    IncreaseLight-scattering intensity of Abeta(1-40) with HNG
    Study

    n: not reported in source

    Abeta(1-40) aggregation assay
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    the interactions of both HN and HNG with Abeta(1-40) induced quick and significant increase of light-scattering intensity

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 04LabNot a test of Humanin aloneIn vitro (cell-free)Mechanism

    The humanin analogue HNG caused an obvious morphological change of Abeta(1-40) from fibrillary to amorphous.

    In plain wordsIn lab tests, a humanin analogue changed amyloid beta from fibre-like to shapeless clumps.

    Peptide
    Humanin
    Outcome
    Not applicableAbeta(1-40) morphology with HNG
    Study

    n: not reported in source

    Abeta(1-40) morphology
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    HNG also caused obvious morphological alteration from fibrillary to amorphous

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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