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Study · Measured the body's own peptide · 2003

2 results

Arrest of cell cycle by inhibition of ribonucleotide reductase induces accumulation of NAD+ by Mn2+-supplemented growth of Corynebacterium ammoniagenes.

Abbouni B, Elhariry HM, Auling G

Biotechnology letters1 Jan 2003Cited by 2 (Europe PMC)

PMID12882290 (opens in a new tab)DOI10.1023/a:1021919404066 (opens in a new tab)PepBankPUB-12882290
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Activity measurement

    In Corynebacterium ammoniagenes cultures, hydroxyurea treatment enhanced natural NAD+ accumulation fourfold through a salvage biosynthetic pathway.

    In plain wordsIn lab tests with bacteria, hydroxyurea increased natural NAD+ accumulation fourfold compared with untreated cultures.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseNAD+ accumulation
    Study

    Corynebacterium ammoniagenesn: not reported in source

    ATCC 6872 fermentation cultures
    Comparator
    Untreated cultures
    Outcome group
    Synthesis and manufacturing · Pharmacology

    Source sentences

    Summary
    The cultures treated with HU or MP had, respectively, a fourfold or sixfold enhanced accumulation of NAD+ by a salvage biosynthetic pathway.
    1 context sentence
    Summary · context
    Cell division of the wild type strain Corynebacterium (formerly Brevibacterium) ammoniagenes ATCC 6872 which requires 1 microM Mn2+ for balanced growth was inhibited by addition of 20 mM hydroxyurea (HU) or 10 mM p-methoxyphenol (MP) to a Mn2+-supplemented fermentation medium at an appropriate time.

    This result measures the body's own NAD+ (nicotinamide adenine dinucleotide). Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Activity measurement

    In Corynebacterium ammoniagenes cultures, p-methoxyphenol treatment enhanced natural NAD+ accumulation sixfold through a salvage biosynthetic pathway.

    In plain wordsIn lab tests with bacteria, p-methoxyphenol increased natural NAD+ accumulation sixfold compared with untreated cultures.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseNAD+ accumulation
    Study

    Corynebacterium ammoniagenesn: not reported in source

    ATCC 6872 fermentation cultures
    Comparator
    Untreated cultures
    Outcome group
    Synthesis and manufacturing · Pharmacology

    Source sentences

    Summary
    The cultures treated with HU or MP had, respectively, a fourfold or sixfold enhanced accumulation of NAD+ by a salvage biosynthetic pathway.
    1 context sentence
    Summary · context
    Cell division of the wild type strain Corynebacterium (formerly Brevibacterium) ammoniagenes ATCC 6872 which requires 1 microM Mn2+ for balanced growth was inhibited by addition of 20 mM hydroxyurea (HU) or 10 mM p-methoxyphenol (MP) to a Mn2+-supplemented fermentation medium at an appropriate time.

    This result measures the body's own NAD+ (nicotinamide adenine dinucleotide). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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