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Study · In vitro (cells) · 2003

4 results

Proopiomelanocortin peptides and sebogenesis.

Zhang L, Anthonavage M, Huang Q, Li WH, Eisinger M

Annals of the New York Academy of Sciences1 Jun 2003Cited by 38 (Europe PMC)

PMID12851311 (opens in a new tab)DOI10.1111/j.1749-6632.2003.tb03175.x (opens in a new tab)PepBankPUB-12851311
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In primary human sebocytes, NDP alpha-MSH increased synthesis of the sebaceous-specific lipid squalene in a dose-dependent manner.

    In plain wordsIn human oil-gland cells in a dish, NDP alpha-MSH raised squalene production as the dose went up.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseSebaceous-specific lipid (squalene) synthesis
    Study

    humann: not reported in source

    Primary human sebocyte culture
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Analysis by high-performance thin-layer chromatography (HPTLC) of (14)C-acetate-labeled lipids showed a dose-dependent increase in synthesis of sebaceous-specific lipid (i.e., squalene) induced by NDP alpha-MSH.
    1 context sentence
    Summary · context
    To study the role of proopiomelanocortin (POMC) peptides in the regulation of human sebaceous lipid production and sebocyte differentiation, we established a primary human sebocyte culture system.
  2. 02LabIn vitro (cells)Mechanism

    In primary human sebocytes, MC5-R expression rose substantially after treatment with NDP alpha-MSH or bovine pituitary extract from a low level under serum-free condition.

    In plain wordsIn human oil-gland cells in a dish, NDP alpha-MSH raised the level of the MC5-R receptor.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseMC5-R expression
    Study

    humann: not reported in source

    Primary human sebocyte culture
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Molecular studies using RT-PCR showed a low level of human MC5-R expression under serum-free condition but a substantial increase after treatment with NDP alpha-MSH or BPE.
    1 context sentence
    Summary · context
    To study the role of proopiomelanocortin (POMC) peptides in the regulation of human sebaceous lipid production and sebocyte differentiation, we established a primary human sebocyte culture system.
  3. 03LabIn vitro (cells)Mechanism

    In primary human sebocytes, MC1-R expression remained the same, independent of treatment with NDP alpha-MSH or bovine pituitary extract.

    In plain wordsIn human oil-gland cells in a dish, NDP alpha-MSH did not change the level of the MC1-R receptor.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeMC1-R expression
    Study

    humann: not reported in source

    Primary human sebocyte culture
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, MC1-R expression remained the same, independent of treatment.
    1 context sentence
    Summary · context
    Molecular studies using RT-PCR showed a low level of human MC5-R expression under serum-free condition but a substantial increase after treatment with NDP alpha-MSH or BPE.

Studies that did not test the peptide alone1

In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan I (afamelanotide).

  1. 04LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cells)Efficacy outcome

    In primary human sebocytes, differentiation induced by POMC-derived peptides such as MSH, ACTH or bovine pituitary extract produced prominent cytoplasmic lipid droplets.

    In plain wordsIn human oil-gland cells in a dish, several POMC-derived peptides, MSH among them, caused cells to fill with lipid droplets.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseSebocyte differentiation induced by POMC-derived peptides
    Study

    humann: not reported in source

    Primary human sebocyte culture
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    Differentiation of sebocytes, induced by POMC-derived peptides such as MSH, adrenocorticotropic hormone (ACTH), or bovine pituitary extract (BPE), resulted in the appearance of prominent cytoplasmic lipid droplets.
    1 context sentence
    Summary · context
    To study the role of proopiomelanocortin (POMC) peptides in the regulation of human sebaceous lipid production and sebocyte differentiation, we established a primary human sebocyte culture system.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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