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Study · In vitro (cells) · 2003

2 results

The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

Hashimoto Y, Niikura T, Chiba T, Tsukamoto E, Kadowaki H, Nishitoh H, Yamagishi Y, Ishizaka M, Yamada M, Nawa M, Terashita K, Aiso S, Ichijo H, Nishimoto I

The Journal of pharmacology and experimental therapeutics26 Jun 2003Cited by 63 (Europe PMC)

PMID12829723 (opens in a new tab)DOI10.1124/jpet.103.051383 (opens in a new tab)PepBankPUB-12829723
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In neuronal cells, cell death caused by constitutively active ASK1 was sensitive to humanin, which suppressed it.

    In plain wordsIn lab neuron cells, humanin reduced cell death caused by an active form of the ASK1 enzyme.

    Peptide
    Humanin
    Outcome
    DecreaseConstitutively active ASK1-induced neuronal cell death
    Study

    n: not reported in source

    neurohybrid cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Constitutively active ASK1 (caASK1) caused DEVD/GEE-sensitive cell death in a manner resistant to PTX and sensitive to Humanin
  2. 02LabIn vitro (cells)Mechanism

    In neurohybrid cells expressing EGFR/AbetaPP hybrids, humanin suppressed neuronal cell death.

    In plain wordsIn lab neuron cells, humanin reduced cell death triggered by a pairing of the amyloid precursor protein region.

    Peptide
    Humanin
    Outcome
    DecreaseEGFR/AbetaPP hybrid-induced neuronal cell death
    Study

    n: not reported in source

    neurohybrid cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Humanin, which also suppressed neuronal cell death by EGFR/AbetaPP hybrid.
    1 context sentence
    Summary · context
    In neurohybrid cells expressing fusion constructs of the epidermal growth factor (EGF) receptor with AbetaPPCD (EGFR/AbetaPP hybrids), EGF drastically enhanced neuronal cell death in a manner sensitive to acetyl-l-aspartyl-l-glutamyl-l-valyl-l-aspartyl-aldehyde (Ac-DEVD-CHO; DEVD), GSH-ethyl ester (…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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