In human HepG2 cells, expression of the thymosin beta‑4 gene was up-regulated in hypoxia-acclimatized cells compared with cells exposed to normoxia.
In plain wordsIn liver cancer cells adapted to low oxygen, the cells' own thymosin beta‑4 gene was more active than in cells kept at normal oxygen.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- IncreaseThymosin beta-4 expression in hypoxia-acclimatized cells
- Study
humann: not reported in source
HepG2 cells, hypoxia-acclimatized- Comparator
- Cells exposed to normoxia
- Outcome group
- Receptor activity and mechanism · Whole body
Source sentences
The expressions of mitochondrion ND4, ferritin, thymosin beta-4 and TPT1 were up-regulated, while the expressions of mitochondrion ND1 gene and metalloproease-1 gene were down-regulated.
1 context sentence(design, population, supporting numbers)
the differentially expressed genes of HepG2 cells exposed to normoxia, acute hypoxia-treated cells which were exposed to 1% oxygen for 48 h, and hypoxia-acclimatized HepG2 cells which were cultured for 6 circles of alternate low oxygen (1% oxygen for 24 h) and normal oxygen (21% oxygen for 24 h), we…
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.