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Study · In vitro (cells) · 2003

7 results

Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.

Florio T, Thellung S, Corsaro A, Bocca L, Arena S, Pattarozzi A, Villa V, Massa A, Diana F, Schettini D, Barbieri F, Ravetti JL, Spaziante R, Giusti M, Schettini G

Clinical endocrinology1 Jul 2003Cited by 36 (Europe PMC)

PMID12807513 (opens in a new tab)DOI10.1046/j.1365-2265.2003.01811.x (opens in a new tab)PepBankPUB-12807513
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human pituitary adenoma cells, lanreotide inhibited PMA-stimulated proliferation in 10/13 adenomas.

    In plain wordsIn cells from human pituitary tumors, lanreotide inhibited proliferation under PMA stimulation.

    Peptide
    Lanreotide
    Outcome
    DecreasePMA-stimulated cell proliferation
    Study

    humann = 13

    primary GH-secreting pituitary adenoma cells
    Comparator
    PMA stimulation
    Outcome group
    Tumor growth · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Somatostatin and lanreotide inhibited cell proliferation in phorbol ester (PMA)-stimulated conditions (10/13 adenomas), as well as after fetal calf serum (3/3 adenomas) or IGF-I stimulation (2/2 adenomas).
    1 context sentence
    Summary · context
    This study was aimed to characterize the intracellular mechanisms mediating the in vitro antiproliferative and antisecretory effects of somatostatin and its analogue lanreotide, on primary cultures of GH-secreting pituitary adenoma cells.
  2. 02LabIn vitro (cells)Activity measurement

    In human pituitary adenoma cells, lanreotide inhibited fetal calf serum-stimulated proliferation in 3/3 adenomas.

    In plain wordsIn cells from human pituitary tumors, lanreotide inhibited proliferation under fetal calf serum stimulation.

    Peptide
    Lanreotide
    Outcome
    DecreaseSerum-stimulated cell proliferation
    Study

    humann = 3

    primary GH-secreting pituitary adenoma cells
    Comparator
    fetal calf serum stimulation
    Outcome group
    Tumor growth · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Somatostatin and lanreotide inhibited cell proliferation in phorbol ester (PMA)-stimulated conditions (10/13 adenomas), as well as after fetal calf serum (3/3 adenomas) or IGF-I stimulation (2/2 adenomas).
    1 context sentence
    Summary · context
    This study was aimed to characterize the intracellular mechanisms mediating the in vitro antiproliferative and antisecretory effects of somatostatin and its analogue lanreotide, on primary cultures of GH-secreting pituitary adenoma cells.
  3. 03LabIn vitro (cells)Activity measurement

    In human pituitary adenoma cells, lanreotide inhibited IGF-I-stimulated proliferation in 2/2 adenomas.

    In plain wordsIn cells from human pituitary tumors, lanreotide inhibited proliferation under IGF-I stimulation.

    Peptide
    Lanreotide
    Outcome
    DecreaseIGF-I-stimulated cell proliferation
    Study

    humann = 2

    primary GH-secreting pituitary adenoma cells
    Comparator
    IGF-I stimulation
    Outcome group
    Tumor growth · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Somatostatin and lanreotide inhibited cell proliferation in phorbol ester (PMA)-stimulated conditions (10/13 adenomas), as well as after fetal calf serum (3/3 adenomas) or IGF-I stimulation (2/2 adenomas).
    1 context sentence
    Summary · context
    This study was aimed to characterize the intracellular mechanisms mediating the in vitro antiproliferative and antisecretory effects of somatostatin and its analogue lanreotide, on primary cultures of GH-secreting pituitary adenoma cells.
  4. 04LabIn vitro (cells)Activity measurement

    In human pituitary adenoma cells, lanreotide significantly inhibited the phorbol ester-dependent increase in GH secretion.

    In plain wordsIn cells from human pituitary tumors, lanreotide reduced GH secretion under phorbol ester stimulation.

    Peptide
    Lanreotide
    Outcome
    DecreasePhorbol ester-stimulated GH secretion
    Study

    humann: not reported in source

    primary GH-secreting pituitary adenoma cells
    Comparator
    phorbol ester stimulation
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Somatostatin and also lanreotide caused significant inhibition of phorbol ester, forskolin, GHRH and KCl-dependent increase of GH secretion in the culture medium.
    1 context sentence
    Summary · context
    This study was aimed to characterize the intracellular mechanisms mediating the in vitro antiproliferative and antisecretory effects of somatostatin and its analogue lanreotide, on primary cultures of GH-secreting pituitary adenoma cells.
  5. 05LabIn vitro (cells)Activity measurement

    In human pituitary adenoma cells, lanreotide significantly inhibited the forskolin-dependent increase in GH secretion.

    In plain wordsIn cells from human pituitary tumors, lanreotide reduced GH secretion under forskolin stimulation.

    Peptide
    Lanreotide
    Outcome
    DecreaseForskolin-stimulated GH secretion
    Study

    humann: not reported in source

    primary GH-secreting pituitary adenoma cells
    Comparator
    forskolin stimulation
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Somatostatin and also lanreotide caused significant inhibition of phorbol ester, forskolin, GHRH and KCl-dependent increase of GH secretion in the culture medium.
    1 context sentence
    Summary · context
    This study was aimed to characterize the intracellular mechanisms mediating the in vitro antiproliferative and antisecretory effects of somatostatin and its analogue lanreotide, on primary cultures of GH-secreting pituitary adenoma cells.
  6. 06LabIn vitro (cells)Activity measurement

    In human pituitary adenoma cells, lanreotide significantly inhibited the GHRH-dependent increase in GH secretion.

    In plain wordsIn cells from human pituitary tumors, lanreotide reduced GH secretion under GHRH stimulation.

    Peptide
    Lanreotide
    Outcome
    DecreaseGHRH-stimulated GH secretion
    Study

    humann: not reported in source

    primary GH-secreting pituitary adenoma cells
    Comparator
    GHRH stimulation
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Somatostatin and also lanreotide caused significant inhibition of phorbol ester, forskolin, GHRH and KCl-dependent increase of GH secretion in the culture medium.
    1 context sentence
    Summary · context
    This study was aimed to characterize the intracellular mechanisms mediating the in vitro antiproliferative and antisecretory effects of somatostatin and its analogue lanreotide, on primary cultures of GH-secreting pituitary adenoma cells.
  7. 07LabIn vitro (cells)Activity measurement

    In human pituitary adenoma cells, lanreotide significantly inhibited the KCl-dependent increase in GH secretion.

    In plain wordsIn cells from human pituitary tumors, lanreotide reduced GH secretion under KCl stimulation.

    Peptide
    Lanreotide
    Outcome
    DecreaseKCl-stimulated GH secretion
    Study

    humann: not reported in source

    primary GH-secreting pituitary adenoma cells
    Comparator
    KCl stimulation
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Somatostatin and also lanreotide caused significant inhibition of phorbol ester, forskolin, GHRH and KCl-dependent increase of GH secretion in the culture medium.
    1 context sentence
    Summary · context
    This study was aimed to characterize the intracellular mechanisms mediating the in vitro antiproliferative and antisecretory effects of somatostatin and its analogue lanreotide, on primary cultures of GH-secreting pituitary adenoma cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

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