Skip to content

Study · Animal study (in vivo) · rat · 2003

6 results

Growth hormone secretagogues modulate the electrical and contractile properties of rat skeletal muscle through a ghrelin-specific receptor.

Pierno S, De Luca A, Desaphy JF, Fraysse B, Liantonio A, Didonna MP, Lograno M, Cocchi D, Smith RG, Camerino DC

British journal of pharmacology1 Jun 2003Cited by 34 (Europe PMC)

PMID12788817 (opens in a new tab)PMCIDPMC1573883 (opens in a new tab)DOI10.1038/sj.bjp.0705284 (opens in a new tab)PepBankPUB-12788817
Source linkPubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats, chronic hexarelin treatment failed to restore the electrical and contractile properties of skeletal muscle, unlike GH.

    In plain wordsIn aged rats, long-term hexarelin did not restore muscle function, unlike growth hormone.

    Peptide
    Hexarelin
    Outcome
    No significant changeElectrical and contractile properties in aged rats after chronic hexarelin
    Study

    ratn: not reported in source

    Aged rats
    Comparator
    Chronic GH
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated · chronicAs given in this study (rat).

    Source sentences

    Summary
    In contrast to GH, chronic treatment of aged rats with hexarelin or L-163,255 failed to restore the electrical and contractile muscle properties.
    1 context sentence
    Summary · context
    Ageing is a condition characterised by a deficit of GH secretion, which in turn modifies the electrical and contractile properties of skeletal muscle.
  2. 02LabEx vivo tissueMechanism

    In rat skeletal muscle in vitro, hexarelin dose dependently reduced resting chloride conductance.

    In plain wordsIn rat muscle tissue, hexarelin lowered the resting chloride flow in a dose-dependent way.

    Peptide
    Hexarelin
    Outcome
    DecreaseResting chloride conductance (gCl) in skeletal muscle
    Study

    ratn: not reported in source

    Rat skeletal muscle fibres, microelectrode technique
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    (2) By means of the intracellular microelectrode technique, we found that in vitro application of hexarelin and L-163,255 dose dependently reduced resting chloride (gCl) and potassium (gK) conductances in rat skeletal muscle.
    1 context sentence
    Summary · context
    Here, we consider the possibility that GHS can target a specific receptor in rat skeletal muscle and have a role in the control of muscle function.
  3. 03LabEx vivo tissueMechanism

    In rat skeletal muscle in vitro, hexarelin dose dependently reduced resting potassium conductance.

    In plain wordsIn rat muscle tissue, hexarelin lowered the resting potassium flow in a dose-dependent way.

    Peptide
    Hexarelin
    Outcome
    DecreaseResting potassium conductance (gK) in skeletal muscle
    Study

    ratn: not reported in source

    Rat skeletal muscle fibres, microelectrode technique
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    (2) By means of the intracellular microelectrode technique, we found that in vitro application of hexarelin and L-163,255 dose dependently reduced resting chloride (gCl) and potassium (gK) conductances in rat skeletal muscle.
    1 context sentence
    Summary · context
    Here, we consider the possibility that GHS can target a specific receptor in rat skeletal muscle and have a role in the control of muscle function.
  4. 04LabEx vivo tissueMechanism

    In rat skeletal muscle in vitro, the GHS-receptor antagonist [D-Lys-3]-GHRP-6 and phospholipase C or PKC inhibitors prevented the hexarelin-induced fall in gCl and gK.

    In plain wordsIn rat muscle tissue, blocking the receptor or its signal pathway stopped the effect of hexarelin on ion flow.

    Peptide
    Hexarelin
    Outcome
    No significant changeConductance reduction with GHS-receptor antagonist or PLC/PKC inhibitors
    Study

    ratn: not reported in source

    Rat skeletal muscle fibres, microelectrode technique
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These effects were prevented by the GHS-receptor antagonist [D-Lys-3]-GHRP-6, and by either phospholipase C or protein kinase C (PKC) inhibitors.
    2 context sentences
    Summary · context
    (2) By means of the intracellular microelectrode technique, we found that in vitro application of hexarelin and L-163,255 dose dependently reduced resting chloride (gCl) and potassium (gK) conductances in rat skeletal muscle.
    Summary · context
    Here, we consider the possibility that GHS can target a specific receptor in rat skeletal muscle and have a role in the control of muscle function.
  5. 05LabEx vivo tissueMechanism

    In rat skeletal muscle in vitro, hexarelin and L-163,255 shifted the mechanical threshold for contraction towards more negative voltages.

    In plain wordsIn rat muscle tissue, hexarelin made the muscle fibres contract at a more negative voltage.

    Peptide
    Hexarelin
    Outcome
    DecreaseMechanical threshold for muscle fibre contraction
    Study

    ratn: not reported in source

    Rat skeletal muscle fibres, microelectrode technique
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    (3) Both GHS shifted the mechanical threshold for the contraction of muscle fibres towards more negative voltages.
    1 context sentence
    Summary · context
    Here, we consider the possibility that GHS can target a specific receptor in rat skeletal muscle and have a role in the control of muscle function.
  6. 06LabEx vivo tissueMechanism

    In muscle from aged rats treated with GH, hexarelin applied in vitro antagonised the GH benefit on gCl and gK.

    In plain wordsIn muscle from aged rats, hexarelin applied in the lab opposed the good effect of growth hormone on ion flow.

    Peptide
    Hexarelin
    Outcome
    DecreaseHexarelin effect on GH benefit for gCl and gK in aged-rat muscle
    Study

    ratn: not reported in source

    Muscle from aged rats chronically treated with GH
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, the two GHS applied in vitro were able to antagonise the beneficial effect on gCl and gK obtained through chronic treatment of aged animals with GH.
    1 context sentence
    Summary · context
    Here, we consider the possibility that GHS can target a specific receptor in rat skeletal muscle and have a role in the control of muscle function.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.