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Study · Not a test of the peptide alone · 2003

5 results

Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization.

Terashita K, Hashimoto Y, Niikura T, Tajima H, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Nawa M, Kita Y, Aiso S, Nishimoto I

Journal of neurochemistry1 Jun 2003Cited by 64 (Europe PMC)

PMID12787071 (opens in a new tab)DOI10.1046/j.1471-4159.2003.01797.x (opens in a new tab)PepBankPUB-12787071
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01LabNot a test of Humanin aloneIn vitro (cells)Activity measurement

    A humanin variant with D-Ser at position 14 protected neuronal cells more potently than humanin, by two to three orders of magnitude.

    In plain wordsIn lab neuron cells, a humanin variant with a changed amino acid protected cells far more strongly than humanin.

    Peptide
    Humanin
    Outcome
    IncreaseNeuroprotection by HN with D-Ser at position 14
    Study

    n: not reported in source

    neuronal cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    HN with D-Ser at position 14 exerts neuroprotection more potently than HN by two to three orders of magnitude

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneIn vitro (cells)Activity measurement

    D-Ser7 substitution did not affect the rescue function of humanin.

    In plain wordsIn lab neuron cells, changing amino acid 7 to its mirror form did not change how well humanin protected cells.

    Peptide
    Humanin
    Outcome
    No significant changeNeuroprotection by HN with D-Ser at position 7
    Study

    n: not reported in source

    neuronal cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    D-Ser7 substitution does not affect the rescue function of HN.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03LabNot a test of Humanin aloneIn vitro (cells)Activity measurement

    S7A substitution nullified the function of humanin.

    In plain wordsIn lab neuron cells, replacing amino acid 7 with alanine removed the protective effect of humanin.

    Peptide
    Humanin
    Outcome
    DecreaseNeuroprotection by HN with S7A substitution
    Study

    n: not reported in source

    neuronal cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    On the other hand, S7A substitution nullified the HN function.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    Experiments indicated that Ser7 is necessary for self-dimerization of humanin, which is essential for its neuroprotection.

    In plain wordsIn lab tests, amino acid 7 was needed for humanin to pair with itself, and pairing was needed for protection.

    Peptide
    Humanin
    Outcome
    Not applicableSelf-dimerization of HN and Ser7
    Study

    n: not reported in source

    neuronal cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Multiple series of experiments indicated that Ser7 is necessary for self-dimerization of HN, which is essential for neuroprotection by this factor.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  5. 05LabNot a test of Humanin aloneIn vitro (cells)Activity measurement

    A very potent humanin derivative was fully neuroprotective at 10 pM against 25 microM Abeta1-43.

    In plain wordsIn lab neuron cells, a modified humanin fully protected cells against amyloid beta at a very low concentration.

    Peptide
    Humanin
    Outcome
    IncreaseNeuroprotection by potent HN derivative against Abeta1-43
    Study

    n: not reported in source

    neuronal cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Measurements

    Fully neuroprotective concentration
    10 pM
    HN derivative vs 25 microM Abeta1-43

    Source sentences

    Summary
    allowing for the construction of a very potent HN derivative that was fully neuroprotective at 10 pM against 25 microM A beta1-43

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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