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Study · Animal study (in vivo) · mouse · 2003

6 results

Corticosteroid-impairment of healing and gastric pentadecapeptide BPC-157 creams in burned mice.

Sikiric P, Seiwerth S, Mise S, Staresinic M, Bedekovic V, Zarkovic N, Borovic S, Gjurasin M, Boban-Blagaic A, Batelja L, Rucman R, Anic T

Burns : journal of the International Society for Burn Injuries1 Jun 2003Cited by 38 (Europe PMC)

PMID12781609 (opens in a new tab)DOI10.1016/s0305-4179(03)00004-4 (opens in a new tab)PepBankPUB-12781609
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In thermally injured mice, BPC‑157 cream improved burn healing on microscopic and tensionmetry assessment compared with a neutral cream.

    In plain wordsIn mice with burns, BPC‑157 cream improved burn healing more than a neutral cream.

    Peptide
    BPC-157
    Outcome
    IncreaseBurn healing (microscopy and tensionmetry)
    Study

    mousen: not reported in source

    thermal burn with corticosteroid impairment
    Comparator
    Neutral cream
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    three levels in a cream · topical creamAs given in this study (mouse).

    Source sentences

    Summary
    Pentadecapeptide BPC-157 consistently improved given burn healing (both microscopical and tensionmetry assessment)
    2 context sentences
    Summary · context
    The amelioration of corticosteroid-impairment of healing by a stable gastric pentadecapeptide BPC-157 (GEPPPGKPADDAGLV, M(w) 1419, currently in early clinical trials for inflammatory bowel disease) was studied in thermally injured mice.
    Summary · context
    The injury was subsequently treated by topical application of a thin layer of pentadecapeptide BPC-157 cream at three different levels a neutral cream of no treatment.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice treated with methylprednisolone, BPC‑157 cream counteracted the corticosteroid impairment of burn healing.

    In plain wordsIn mice with burns given a steroid, BPC‑157 cream reduced the steroid's harm to healing.

    Peptide
    BPC-157
    Outcome
    DecreaseCorticosteroid impairment of burn healing
    Study

    mousen: not reported in source

    thermal burn with corticosteroid impairment
    Comparator
    Neutral cream
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    three levels in a cream · topical creamAs given in this study (mouse).

    Source sentences

    Summary
    and counteracted corticosteroid-impairment of burn healing.
    2 context sentences
    Summary · context
    The amelioration of corticosteroid-impairment of healing by a stable gastric pentadecapeptide BPC-157 (GEPPPGKPADDAGLV, M(w) 1419, currently in early clinical trials for inflammatory bowel disease) was studied in thermally injured mice.
    Summary · context
    The injury was subsequently treated by topical application of a thin layer of pentadecapeptide BPC-157 cream at three different levels a neutral cream of no treatment.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice not given a corticosteroid, BPC reduced burn-related gastric lesions (an anti-ulcer effect of its own).

    In plain wordsIn burned mice without a steroid, BPC reduced stomach lesions caused by the burn.

    Peptide
    BPC-157
    Outcome
    DecreaseBurn-gastric lesions in mice without corticosteroid
    Study

    mousen: not reported in source

    thermal burn with corticosteroid impairment
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    three levels in a cream · topical creamAs given in this study (mouse).

    Source sentences

    Summary
    In burn-gastric lesions investigation of the effects of BPC showed an anti-ulcer effect of its own in burned non-corticosteroid-treated mice
    2 context sentences
    Summary · context
    The amelioration of corticosteroid-impairment of healing by a stable gastric pentadecapeptide BPC-157 (GEPPPGKPADDAGLV, M(w) 1419, currently in early clinical trials for inflammatory bowel disease) was studied in thermally injured mice.
    Summary · context
    The injury was subsequently treated by topical application of a thin layer of pentadecapeptide BPC-157 cream at three different levels a neutral cream of no treatment.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice given methylprednisolone, BPC potentiated the anti-ulcer effect on burn-gastric lesions.

    In plain wordsIn burned mice given a steroid, BPC increased the protection against stomach lesions.

    Peptide
    BPC-157
    Outcome
    DecreaseBurn-gastric lesions in methylprednisolone-treated mice
    Study

    mousen: not reported in source

    thermal burn with corticosteroid impairment
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    three levels in a cream · topical creamAs given in this study (mouse).

    Source sentences

    Summary
    and potentiated the anti-ulcer effect observed in 6alpha-methylprednisolone-treated mice.
    2 context sentences
    Summary · context
    The amelioration of corticosteroid-impairment of healing by a stable gastric pentadecapeptide BPC-157 (GEPPPGKPADDAGLV, M(w) 1419, currently in early clinical trials for inflammatory bowel disease) was studied in thermally injured mice.
    Summary · context
    The injury was subsequently treated by topical application of a thin layer of pentadecapeptide BPC-157 cream at three different levels a neutral cream of no treatment.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice given methylprednisolone, BPC‑157 inhibited corticosteroid immunosuppression.

    In plain wordsIn mice given a steroid, BPC‑157 reduced the steroid's suppression of the immune system.

    Peptide
    BPC-157
    Outcome
    DecreaseCorticosteroid immunosuppression
    Study

    mousen: not reported in source

    thermal burn with corticosteroid impairment
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    three levels in a cream · topical creamAs given in this study (mouse).

    Source sentences

    Summary
    Pentadecapeptide BPC-157 inhibited corticosteroid immunosuppression.
    2 context sentences
    Summary · context
    The amelioration of corticosteroid-impairment of healing by a stable gastric pentadecapeptide BPC-157 (GEPPPGKPADDAGLV, M(w) 1419, currently in early clinical trials for inflammatory bowel disease) was studied in thermally injured mice.
    Summary · context
    The injury was subsequently treated by topical application of a thin layer of pentadecapeptide BPC-157 cream at three different levels a neutral cream of no treatment.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In spleen cells from methylprednisolone-treated mice, the addition of BPC‑157 returned the reduced cell reactivity to the values of control healthy animals.

    In plain wordsIn spleen cells from steroid-treated mice, BPC‑157 brought cell reactivity back to the level of healthy control animals.

    Peptide
    BPC-157
    Outcome
    IncreaseSpleen cell reactivity to nitrogen
    Study

    mousen: not reported in source

    thermal burn with corticosteroid impairment
    Comparator
    Methylprednisolone-treated animals without BPC-157
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    1 µg/g cream · topical creamAs given in this study (mouse).

    Source sentences

    Summary
    In vitro, in spleenic cells assessment, animals (sacrificed at day 21) treated with 6alpha-methylprednisolone 1mg showed decreased reactivity to nitrogen in comparison with control, healthy animals, while the addition of BPC-157 (1 microg/g cream) returned cell reactivity to values noted in control healthy animals.
    2 context sentences
    Summary · context
    The amelioration of corticosteroid-impairment of healing by a stable gastric pentadecapeptide BPC-157 (GEPPPGKPADDAGLV, M(w) 1419, currently in early clinical trials for inflammatory bowel disease) was studied in thermally injured mice.
    Summary · context
    The injury was subsequently treated by topical application of a thin layer of pentadecapeptide BPC-157 cream at three different levels a neutral cream of no treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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