Overexpression of the thymosin beta-4 gene is associated with malignant progression of SW480 colon cancer cells.

Wang WS, Chen PM, Hsiao HL, Ju SY, Su Y

Oncogene1 May 2003Cited by 62 (Europe PMC)

PMID12761500DOI10.1038/sj.onc.1206404PepBankPUB-12761500

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In human SW480 colon carcinoma cells, overexpression of the thymosin beta‑4 gene altered cell morphology and the cortical actin cytoskeleton.
In plain wordsIn colon cancer cells, adding extra copies of the thymosin beta‑4 gene changed the cell shape and the actin skeleton.
Peptide
Thymosin beta-4 (human)
Outcome
Direction not reportedCell morphology and cortical actin cytoskeleton
Study
humann: not reported in source
SW480 colon carcinoma cells stably overexpressing thymosin beta-4
Outcome group
Tumor growth · Cancer
Source sentences
Summary
We found that both the morphology and the cortical actin cytoskeleton of SW480 cells were altered by Tbeta-4 overexpression.
1 context sentence(design, population, supporting numbers)
Summary · context
To address the above questions, Tbeta-4-overexpressing human colon carcinoma (SW480) cells were established by stable transfection and their phenotypic changes were monitored.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1276150001
02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In SW480 cells, thymosin beta‑4 gene overexpression decreased the cellular level of E-cadherin and the amount at intercellular junctions.
In plain wordsIn colon cancer cells, extra thymosin beta‑4 gene copies lowered the level of the adhesion protein E-cadherin.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseE-cadherin level
Study
humann: not reported in source
SW480 colon carcinoma cells stably overexpressing thymosin beta-4
Outcome group
Tumor growth · Cancer
Source sentences
Summary
both cellular level and that distributed over the intercellular junctions of the E-cadherin were decreased in the Tbeta-4 overexpressers
1 context sentence(design, population, supporting numbers)
Summary · context
To address the above questions, Tbeta-4-overexpressing human colon carcinoma (SW480) cells were established by stable transfection and their phenotypic changes were monitored.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1276150002
03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In SW480 cells, thymosin beta‑4 gene overexpression was accompanied by a twofold increase in saturation density.
In plain wordsIn colon cancer cells, extra thymosin beta‑4 gene copies went with cells growing to a twofold higher density.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseSaturation density
Study
humann: not reported in source
SW480 colon carcinoma cells stably overexpressing thymosin beta-4
Outcome group
Tumor growth · Cancer
Source sentences
Summary
which were accompanied by a twofold increase in their saturation densities.
1 context sentence(design, population, supporting numbers)
Summary · context
To address the above questions, Tbeta-4-overexpressing human colon carcinoma (SW480) cells were established by stable transfection and their phenotypic changes were monitored.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1276150003
04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In SW480 cells, thymosin beta‑4 gene overexpression increased the ability to form colonies in soft agar.
In plain wordsIn colon cancer cells, extra thymosin beta‑4 gene copies raised the ability to form colonies in soft agar.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseColony formation in soft agar
Study
humann: not reported in source
SW480 colon carcinoma cells stably overexpressing thymosin beta-4
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Meanwhile, these cells also exhibited an increased ability to form colonies in soft agar.
1 context sentence(design, population, supporting numbers)
Summary · context
To address the above questions, Tbeta-4-overexpressing human colon carcinoma (SW480) cells were established by stable transfection and their phenotypic changes were monitored.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1276150004
05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In SW480 cells, thymosin beta‑4 gene overexpression markedly increased the growth rate.
In plain wordsIn colon cancer cells, extra thymosin beta‑4 gene copies raised the growth rate.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseGrowth rate
Study
humann: not reported in source
SW480 colon carcinoma cells stably overexpressing thymosin beta-4
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Interestingly, a dramatic increase of growth rate was detected in the Tbeta-4 overexpressers, which might be attributed to an accelerated proliferation induced by c-Myc that was activated by nuclear beta-catenin.
1 context sentence(design, population, supporting numbers)
Summary · context
To address the above questions, Tbeta-4-overexpressing human colon carcinoma (SW480) cells were established by stable transfection and their phenotypic changes were monitored.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1276150005
06LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In SW480 cells, thymosin beta‑4 gene overexpression increased motility in two independent migration assays.
In plain wordsIn colon cancer cells, extra thymosin beta‑4 gene copies made the cells move more in two migration tests.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCell motility in two migration assays
Study
humann: not reported in source
SW480 colon carcinoma cells stably overexpressing thymosin beta-4
Outcome group
Cancer cell invasion and metastasis · Cancer
Source sentences
Summary
Finally, a motility increase of these cells was demonstrated by two independent migration assays
1 context sentence(design, population, supporting numbers)
Summary · context
To address the above questions, Tbeta-4-overexpressing human colon carcinoma (SW480) cells were established by stable transfection and their phenotypic changes were monitored.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1276150006
07LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In SW480 cells, thymosin beta‑4 gene overexpression was accompanied by enhanced focal contact.
In plain wordsIn colon cancer cells, extra thymosin beta‑4 gene copies went with stronger focal contacts.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseFocal contact
Study
humann: not reported in source
SW480 colon carcinoma cells stably overexpressing thymosin beta-4
Outcome group
Cancer cell invasion and metastasis · Cancer
Source sentences
Summary
which was accompanied by an enhanced focal contact.
1 context sentence(design, population, supporting numbers)
Summary · context
To address the above questions, Tbeta-4-overexpressing human colon carcinoma (SW480) cells were established by stable transfection and their phenotypic changes were monitored.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-1276150007

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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