Study · In vitro (cells) · 2003
7 resultsGuo B, Zhai D, Cabezas E, Welsh K, Nouraini S, Satterthwait AC, Reed JC
Nature4 May 2003Cited by 503 (Europe PMC)
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Text rights: Publisher copyright. Results still quote short attributed sentences.
5 results from studies that gave the peptide. No result from this study comes from people.
Bax interacts with humanin, an anti-apoptotic peptide of 24 amino acids.
In plain wordsIn lab tests, humanin was found to bind the cell-death protein Bax.
n: not reported in source
cellsSource sentences
Here we show that Bax interacts with humanin (HN), an anti-apoptotic peptide of 24 amino acids encoded in mammalian genomes.
In cells, humanin prevented the translocation of Bax from cytosol to mitochondria.
In plain wordsIn cells, humanin stopped the cell-death protein Bax from moving to the mitochondria.
n: not reported in source
cellsSource sentences
HN prevents the translocation of Bax from cytosol to mitochondria.
The mitochondrial version of humanin, encoded by an identical open reading frame, also bound and suppressed Bax.
In plain wordsIn cells, the mitochondria-made version of humanin also bound and held back the cell-death protein Bax.
n: not reported in source
cellsSource sentences
Notably, the mitochondrial genome contains an identical open reading frame, and the mitochondrial version of HN can also bind and suppress Bax.
Humanin peptides blocked Bax association with isolated mitochondria.
In plain wordsIn lab tests, humanin peptides stopped the cell-death protein Bax from attaching to isolated mitochondria.
n: not reported in source
isolated mitochondriaSource sentences
HN peptides also block Bax association with isolated mitochondria, and suppress cytochrome c release in vitro.
Humanin peptides suppressed cytochrome c release in vitro.
In plain wordsIn lab tests, humanin peptides reduced the release of cytochrome c, a cell-death signal.
n: not reported in source
isolated mitochondriaSource sentences
suppress cytochrome c release in vitro.
HN peptides also block Bax association with isolated mitochondria
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.
Reducing humanin expression with small interfering RNAs sensitized cells to Bax.
In plain wordsIn cells, lowering humanin production made cells more sensitive to the cell-death protein Bax.
n: not reported in source
cellsSource sentences
reducing HN expression by small interfering RNAs sensitizes cells to Bax
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Reducing humanin expression with small interfering RNAs increased Bax translocation to membranes.
In plain wordsIn cells, lowering humanin production let more of the cell-death protein Bax move to membranes.
n: not reported in source
cellsSource sentences
Conversely, reducing HN expression by small interfering RNAs sensitizes cells to Bax and increases Bax translocation to membranes
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.
Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC
Terms as the source lists them.
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