In mouse skin inflammation models, the lymph-specific splice variant LTbeta4 had broader and most often stronger anti-inflammatory activity than the ubiquitous form UTbeta4.
In plain wordsIn mice, a lymph-specific form of thymosin beta‑4 reduced skin inflammation more broadly and more strongly than the ubiquitous form.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- Not applicableAnti-inflammatory activity of LTbeta4 versus UTbeta4 in skin
- Study
mousen: not reported in source
Skin inflammation models: footpad carrageenan, irritant contact dermatitis, allergic contact dermatitis- Comparator
- UTbeta4
- Outcome group
- Inflammation markers · Immune and inflammation
Source sentences
These studies clearly showed that the anti-inflammatory activities of LTbeta4 were broader and most often stronger than those of UTbeta4.
1 context sentence(design, population, supporting numbers)
To compare the anti-inflammatory properties of LTbeta4 and UTbeta4 in the skin in vivo, the biological activities of synthesized polypeptides were assessed using three different strategies: neutrophil infiltration by footpad lambda-carrageenan injection; irritant contact dermatitis to 12-O-tetradeca…
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).