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Study · Animal study (in vivo) · rat · 2003

3 results

Ghrelin plays a minor role in the physiological control of cardiac function in the rat.

Torsello A, Bresciani E, Rossoni G, Avallone R, Tulipano G, Cocchi D, Bulgarelli I, Deghenghi R, Berti F, Locatelli V

Endocrinology1 May 2003Cited by 42 (Europe PMC)

PMID12697684 (opens in a new tab)DOI10.1210/en.2002-221048 (opens in a new tab)PepBankPUB-12697684
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized rats, 7-day hexarelin gave 60% protection against the rise in left ventricular end-diastolic pressure, versus 15% with ghrelin.

    In plain wordsIn rats, hexarelin protected the heart from a pressure rise after blood flow loss more than ghrelin did.

    Peptide
    Hexarelin
    Outcome
    DecreaseLeft ventricular end-diastolic pressure increase after ischemia-reperfusion
    Study

    ratn: not reported in source

    Hypophysectomized rats, isolated hearts with ischemia and reperfusion
    Comparator
    Ghrelin
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    80 microg/kg · 7 dAs given in this study (rat).

    Measurements

    Protection
    60%
    hexarelin
    Protection
    15%
    ghrelin

    Source sentences

    Summary
    Ghrelin was far less effective than hexarelin in preventing increases in left ventricular end-diastolic pressure (15% and 60% protection for ghrelin and hexarelin, respectively), coronary perfusion pressure (10% and 45% reduction), and release of creatine kinase in the heart perfusate (15% and 55% reduction).
    1 context sentence
    Summary · context
    Hypophysectomized rats were treated in vivo for 7 d with either ghrelin (320 microg/kg) or hexarelin (80 microg/kg), and their hearts were subjected in vitro to the ischemia and reperfusion procedure.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized rats, 7-day hexarelin reduced coronary perfusion pressure by 45%, versus 10% with ghrelin.

    In plain wordsIn rats, hexarelin lowered pressure in the heart's blood vessels more than ghrelin did.

    Peptide
    Hexarelin
    Outcome
    DecreaseCoronary perfusion pressure after ischemia-reperfusion
    Study

    ratn: not reported in source

    Hypophysectomized rats, isolated hearts with ischemia and reperfusion
    Comparator
    Ghrelin
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    80 microg/kg · 7 dAs given in this study (rat).

    Measurements

    Reduction
    45%
    hexarelin
    Reduction
    10%
    ghrelin

    Source sentences

    Summary
    Ghrelin was far less effective than hexarelin in preventing increases in left ventricular end-diastolic pressure (15% and 60% protection for ghrelin and hexarelin, respectively), coronary perfusion pressure (10% and 45% reduction), and release of creatine kinase in the heart perfusate (15% and 55% reduction).
    1 context sentence
    Summary · context
    Hypophysectomized rats were treated in vivo for 7 d with either ghrelin (320 microg/kg) or hexarelin (80 microg/kg), and their hearts were subjected in vitro to the ischemia and reperfusion procedure.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In hypophysectomized rats, 7-day hexarelin reduced creatine kinase release from ischemic-reperfused hearts by 55%, versus 15% with ghrelin.

    In plain wordsIn rats, hexarelin lowered a marker of heart damage more than ghrelin did.

    Peptide
    Hexarelin
    Outcome
    DecreaseCreatine kinase release in heart perfusate
    Study

    ratn: not reported in source

    Hypophysectomized rats, isolated hearts with ischemia and reperfusion
    Comparator
    Ghrelin
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    80 microg/kg · 7 dAs given in this study (rat).

    Measurements

    Reduction
    55%
    hexarelin
    Reduction
    15%
    ghrelin

    Source sentences

    Summary
    Ghrelin was far less effective than hexarelin in preventing increases in left ventricular end-diastolic pressure (15% and 60% protection for ghrelin and hexarelin, respectively), coronary perfusion pressure (10% and 45% reduction), and release of creatine kinase in the heart perfusate (15% and 55% reduction).
    1 context sentence
    Summary · context
    Hypophysectomized rats were treated in vivo for 7 d with either ghrelin (320 microg/kg) or hexarelin (80 microg/kg), and their hearts were subjected in vitro to the ischemia and reperfusion procedure.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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