In mammalian cells expressing four chicken MC1R alleles, alpha-MSH and NDP-MSH bound the receptors with similar IC50 values.
In plain wordsIn cells carrying four chicken receptor variants, NDP-MSH and alpha-MSH bound with similar strength.
- Peptide
- Melanotan I (afamelanotide)
- Outcome
- Not applicableNDP-MSH binding to chicken MC1R alleles
- Study
n: not reported in source
Mammalian cells expressing cloned chicken MC1R alleles- Comparator
- alpha-MSH
- Outcome group
- Receptor activity and mechanism · Pharmacology
Source sentences
Four of the clones e(+R), e(+B&D), e(wh)/e(y), E(Rfayoumi) gave receptors to which melanocortin stimulating hormone (alpha-MSH) and NDP-MSH bound with similar IC50 values and responded to alpha-MSH by increasing intracellular cAMP levels in a dose-dependent manner.
1 context sentence(design, population, supporting numbers)
Seven alleles of the chicken melanocortin (MC) 1 receptor were cloned into expression vectors, expressed in mammalian cells and pharmacologically characterized.
In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).