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Study · Animal study (in vivo) · mouse and rat · 2003

9 results

Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice.

Philp D, Badamchian M, Scheremeta B, Nguyen M, Goldstein AL, Kleinman HK

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society1 Jan 2003Cited by 90 (Europe PMC)

PMID12581423 (opens in a new tab)DOI10.1046/j.1524-475x.2003.11105.x (opens in a new tab)PepBankPUB-12581423
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In normal rats, thymosin beta‑4 in phosphate-buffered saline or a hydrogel formulation promoted dermal wound repair.

    In plain wordsIn normal rats, thymosin beta‑4 in saline or a hydrogel helped skin wounds heal.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseDermal wound repair in normal rats
    Study

    ratn: not reported in source

    Dermal wound model in normal rats
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    thymosin beta 4 in either phosphate-buffered saline or a hydrogel formulation is active in promoting dermal wound repair in normal rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, wound contracture was significantly increased with thymosin beta‑4 in phosphate-buffered saline or a hydrogel formulation.

    In plain wordsIn diabetic mice, thymosin beta‑4 increased wound contracture, which is wound closing.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseWound contracture in diabetic mice
    Study

    mousen: not reported in source

    db/db diabetic mice with full-thickness dermal wounds
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    wound contracture and collagen deposition were significantly increased in the mice treated with thymosin beta 4 in either phosphate buffered saline solution or a hydrogel formulation
    1 context sentence
    Summary · context
    Here we report that thymosin beta 4 was also active in accelerating wound repair in full-thickness dermal wounds in both db/db diabetic and aged mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, collagen deposition in wounds was significantly increased with thymosin beta‑4 in phosphate-buffered saline or a hydrogel formulation.

    In plain wordsIn diabetic mice, thymosin beta‑4 increased collagen deposition in wounds.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCollagen deposition in diabetic mice
    Study

    mousen: not reported in source

    db/db diabetic mice with full-thickness dermal wounds
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    wound contracture and collagen deposition were significantly increased in the mice treated with thymosin beta 4 in either phosphate buffered saline solution or a hydrogel formulation
    1 context sentence
    Summary · context
    Here we report that thymosin beta 4 was also active in accelerating wound repair in full-thickness dermal wounds in both db/db diabetic and aged mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, no difference in keratinocyte migration was observed, and all diabetic animals showed almost complete wound coverage at day 8.

    In plain wordsIn diabetic mice, keratinocyte migration did not differ, and all animals had almost fully covered wounds.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeKeratinocyte migration in diabetic mice
    Study

    mousen: not reported in source

    db/db diabetic mice with full-thickness dermal wounds
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No difference was observed in keratinocyte migration, with all of the diabetic animals showing almost complete coverage of the wound at 8 days.
    1 context sentence
    Summary · context
    Here we report that thymosin beta 4 was also active in accelerating wound repair in full-thickness dermal wounds in both db/db diabetic and aged mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice, thymosin beta‑4 increased keratinocyte migration.

    In plain wordsIn aged mice, thymosin beta‑4 increased keratinocyte migration in wounds.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseKeratinocyte migration in aged mice
    Study

    mousen: not reported in source

    Aged mice with full-thickness dermal wounds
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin beta 4 accelerated wound healing in these aged mice, with increases in keratinocyte migration, wound contracture, and collagen deposition.
    2 context sentences
    Summary · context
    Wound healing in 26-month-old (aged) animals was significantly delayed.
    Summary · context
    Here we report that thymosin beta 4 was also active in accelerating wound repair in full-thickness dermal wounds in both db/db diabetic and aged mice.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice, thymosin beta‑4 increased wound contracture.

    In plain wordsIn aged mice, thymosin beta‑4 increased wound contracture, which is wound closing.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseWound contracture in aged mice
    Study

    mousen: not reported in source

    Aged mice with full-thickness dermal wounds
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin beta 4 accelerated wound healing in these aged mice, with increases in keratinocyte migration, wound contracture, and collagen deposition.
    2 context sentences
    Summary · context
    Wound healing in 26-month-old (aged) animals was significantly delayed.
    Summary · context
    Here we report that thymosin beta 4 was also active in accelerating wound repair in full-thickness dermal wounds in both db/db diabetic and aged mice.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice, thymosin beta‑4 increased collagen deposition in wounds.

    In plain wordsIn aged mice, thymosin beta‑4 increased collagen deposition in wounds.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCollagen deposition in aged mice
    Study

    mousen: not reported in source

    Aged mice with full-thickness dermal wounds
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin beta 4 accelerated wound healing in these aged mice, with increases in keratinocyte migration, wound contracture, and collagen deposition.
    2 context sentences
    Summary · context
    Wound healing in 26-month-old (aged) animals was significantly delayed.
    Summary · context
    Here we report that thymosin beta 4 was also active in accelerating wound repair in full-thickness dermal wounds in both db/db diabetic and aged mice.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    The hydrogel formulation of thymosin beta‑4 generally showed wound healing activity similar to thymosin beta‑4 in PBS.

    In plain wordsThymosin beta‑4 in a hydrogel healed wounds about as well as thymosin beta‑4 in saline in these animal studies.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeWound healing, hydrogel versus PBS formulation
    Study

    mousen: not reported in source

    Full-thickness dermal wounds
    Comparator
    Thymosin beta 4 in PBS
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The hydrogel formulation generally showed similar wound healing activity with thymosin beta 4 in PBS.
    1 context sentence
    Summary · context
    Here we report that thymosin beta 4 was also active in accelerating wound repair in full-thickness dermal wounds in both db/db diabetic and aged mice.

Studies that did not test the peptide alone1

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 09AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In aged mice, the seven-amino acid synthetic actin-binding peptide LKKTETQ promoted wound repair comparably to thymosin beta‑4.

    In plain wordsIn aged mice, a short synthetic peptide from the actin-binding part of thymosin beta‑4 helped wounds heal about as well as thymosin beta‑4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseWound repair with synthetic LKKTETQ peptide in aged mice
    Study

    mousen: not reported in source

    Aged mice with full-thickness dermal wounds
    Comparator
    Thymosin beta 4
    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    The actin-binding domain of thymosin beta 4 duplicated in a seven-amino acid synthetic peptide, LKKTETQ, was able to promote repair in the aged animals comparable to that observed with the parent molecule.
    2 context sentences
    Summary · context
    Wound healing in 26-month-old (aged) animals was significantly delayed.
    Summary · context
    Here we report that thymosin beta 4 was also active in accelerating wound repair in full-thickness dermal wounds in both db/db diabetic and aged mice.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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