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Study · In vitro (cells) · 2003

1 result

Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death.

Hashimoto Y, Tsuji O, Niikura T, Yamagishi Y, Ishizaka M, Kawasumi M, Chiba T, Kanekura K, Yamada M, Tsukamoto E, Kouyama K, Terashita K, Aiso S, Lin A, Nishimoto I

Journal of neurochemistry1 Feb 2003Cited by 88 (Europe PMC)

PMID12562529 (opens in a new tab)DOI10.1046/j.1471-4159.2003.01585.x (opens in a new tab)PepBankPUB-12562529
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In neuronal cells, constitutively active JNK-induced cell death was suppressed by humanin, whereas pertussis toxin did not suppress it.

    In plain wordsIn lab neuron cells, humanin reduced cell death driven by an active form of the JNK enzyme.

    Peptide
    Humanin
    Outcome
    DecreaseConstitutively active JNK-induced neuronal cell death
    Study

    n: not reported in source

    neuronal cells with constitutively active JNK
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pertussis toxin (PTX) suppressed APP-mediated cell death but not caJNK-induced cell death, which was suppressed by Humanin
    1 context sentence
    Summary · context
    (ii) constitutively active (ca) JNK caused neuronal cell death and (iii) the pharmacological profile of caJNK-mediated cell death closely coincided with that of APP-mediated cell death.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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