Skip to content

Study · In vitro (cells) · 2003

4 results

Humanin rescues human cerebrovascular smooth muscle cells from Abeta-induced toxicity.

Jung SS, Van Nostrand WE

Journal of neurochemistry1 Jan 2003Cited by 64 (Europe PMC)

PMID12558989 (opens in a new tab)DOI10.1046/j.1471-4159.2003.01524.x (opens in a new tab)PepBankPUB-12558989
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human cerebrovascular smooth muscle cells, 10 microM humanin prevented pathogenic Abeta-induced cell death in a fluorescent cell viability assay.

    In plain wordsIn lab cells from brain blood vessels, humanin protected against cell death caused by amyloid beta.

    Peptide
    Humanin
    Outcome
    DecreaseAbeta-induced HCSM cell death
    Study

    humann: not reported in source

    human cerebrovascular smooth muscle (HCSM) cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 micromAs given in this study (human).

    Source sentences

    Summary
    treatment of HCSM cells with 10 microm HN prevented pathogenic Abeta-induced HCSM cell death using a fluorescent cell viability assay
    2 context sentences
    Summary · context
    We have used human cerebrovascular smooth muscle (HCSM) cells as an in vitro model system to investigate the pathogenic mechanisms of the pathology of CAA.
    Summary · context
    In this report we investigated whether the HN peptide could rescue HCSM cells from Abeta-induced toxicity.
  2. 02LabIn vitro (cells)Efficacy outcome

    In human cerebrovascular smooth muscle cells treated with 10 microM humanin, degradation of alpha-actin was diminished, shown by quantitative immunoblotting.

    In plain wordsIn lab cells from brain blood vessels, humanin reduced the breakdown of a cell protein caused by amyloid beta.

    Peptide
    Humanin
    Outcome
    DecreaseAbeta-induced degradation of HCSM alpha-actin
    Study

    humann: not reported in source

    human cerebrovascular smooth muscle (HCSM) cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 micromAs given in this study (human).

    Source sentences

    Summary
    degradation of HCSM alpha-actin was diminished shown by quantitative immunoblotting.
    3 context sentences
    Summary · context
    treatment of HCSM cells with 10 microm HN
    Summary · context
    We have used human cerebrovascular smooth muscle (HCSM) cells as an in vitro model system to investigate the pathogenic mechanisms of the pathology of CAA.
    Summary · context
    In this report we investigated whether the HN peptide could rescue HCSM cells from Abeta-induced toxicity.
  3. 03LabIn vitro (cells)Mechanism

    In human cerebrovascular smooth muscle cells, humanin did not affect Abeta deposition and fibril formation at the cell surface.

    In plain wordsIn lab cells from brain blood vessels, humanin did not change amyloid beta build-up on the cell surface.

    Peptide
    Humanin
    Outcome
    No significant changeAbeta deposition and fibril formation at the cell surface
    Study

    humann: not reported in source

    human cerebrovascular smooth muscle (HCSM) cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 micromAs given in this study (human).

    Source sentences

    Summary
    Abeta deposition and fibril formation at the cell surface and increased levels of cell-associated AbetaPP were not affected by treatment with HN as demonstrated by a thioflavin T fluorescence assay
    2 context sentences
    Summary · context
    We have used human cerebrovascular smooth muscle (HCSM) cells as an in vitro model system to investigate the pathogenic mechanisms of the pathology of CAA.
    Summary · context
    In this report we investigated whether the HN peptide could rescue HCSM cells from Abeta-induced toxicity.
  4. 04LabIn vitro (cells)Mechanism

    In human cerebrovascular smooth muscle cells, humanin did not affect the increased levels of cell-associated AbetaPP.

    In plain wordsIn lab cells from brain blood vessels, humanin did not change the raised level of the amyloid precursor protein.

    Peptide
    Humanin
    Outcome
    No significant changeCell-associated AbetaPP levels
    Study

    humann: not reported in source

    human cerebrovascular smooth muscle (HCSM) cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10 micromAs given in this study (human).

    Source sentences

    Summary
    increased levels of cell-associated AbetaPP were not affected by treatment with HN as demonstrated by a thioflavin T fluorescence assay and immunochemical methods, respectively
    2 context sentences
    Summary · context
    We have used human cerebrovascular smooth muscle (HCSM) cells as an in vitro model system to investigate the pathogenic mechanisms of the pathology of CAA.
    Summary · context
    In this report we investigated whether the HN peptide could rescue HCSM cells from Abeta-induced toxicity.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.