Comparison of leuprolide acetate and triptorelin in assisted reproductive technology cycles: a prospective, randomized study.

Orvieto R, Kerner R, Krissi H, Ashkenazi J, Ben Rafael Z, Bar-Hava I

Fertility and sterility1 Dec 2002Cited by 7 (Europe PMC)

PMID12477523DOI10.1016/s0015-0282(02)04262-0PepBankPUB-12477523

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

01HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, estrogen levels on hCG administration day did not differ significantly between triptorelin and leuprolide.
In plain wordsIn women undergoing IVF, estrogen levels on hCG administration day did not differ significantly between triptorelin and leuprolide.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeEstrogen on hCG day
Study
n = 52
Comparator
Leuprolide acetate
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mg depotAs given in this study (human).
Source sentences
Summary
No significant differences were observed in the patient age, estrogen, and P levels on day of hCG administration, gonadotropin dosage, number of oocytes retrieved, fertilization rate, percentage of high-quality embryos, and number of embryos transferred.
2 context sentences(design, population, supporting numbers)
Summary · context
An IVF unit of an academic medical center.Fifty-two women who underwent controlled ovarian hyperstimulation and IVF.
Summary · context
Patients were prospectively randomized to receive 3.75 mg depot formulations of either leuprolide or triptorelin on days 21-23 of the menstrual cycle.
Report a problemFND-1247752301
02HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, progesterone levels on hCG administration day did not differ significantly between triptorelin and leuprolide.
In plain wordsIn women undergoing IVF, progesterone levels on hCG administration day did not differ significantly between triptorelin and leuprolide.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeP on hCG day
Study
n = 52
Comparator
Leuprolide acetate
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mg depotAs given in this study (human).
Source sentences
Summary
No significant differences were observed in the patient age, estrogen, and P levels on day of hCG administration, gonadotropin dosage, number of oocytes retrieved, fertilization rate, percentage of high-quality embryos, and number of embryos transferred.
2 context sentences(design, population, supporting numbers)
Summary · context
An IVF unit of an academic medical center.Fifty-two women who underwent controlled ovarian hyperstimulation and IVF.
Summary · context
Patients were prospectively randomized to receive 3.75 mg depot formulations of either leuprolide or triptorelin on days 21-23 of the menstrual cycle.
Report a problemFND-1247752302
03HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, gonadotropin dosage did not differ significantly between triptorelin and leuprolide.
In plain wordsIn women undergoing IVF, gonadotropin dosage did not differ significantly between triptorelin and leuprolide.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeGonadotropin dosage
Study
n = 52
Comparator
Leuprolide acetate
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mg depotAs given in this study (human).
Source sentences
Summary
No significant differences were observed in the patient age, estrogen, and P levels on day of hCG administration, gonadotropin dosage, number of oocytes retrieved, fertilization rate, percentage of high-quality embryos, and number of embryos transferred.
2 context sentences(design, population, supporting numbers)
Summary · context
An IVF unit of an academic medical center.Fifty-two women who underwent controlled ovarian hyperstimulation and IVF.
Summary · context
Patients were prospectively randomized to receive 3.75 mg depot formulations of either leuprolide or triptorelin on days 21-23 of the menstrual cycle.
Report a problemFND-1247752303
04HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, oocyte yield did not differ significantly between triptorelin and leuprolide.
In plain wordsIn women undergoing IVF, oocyte yield did not differ significantly between triptorelin and leuprolide.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeOocytes retrieved
Study
n = 52
Comparator
Leuprolide acetate
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mg depotAs given in this study (human).
Source sentences
Summary
No significant differences were observed in the patient age, estrogen, and P levels on day of hCG administration, gonadotropin dosage, number of oocytes retrieved, fertilization rate, percentage of high-quality embryos, and number of embryos transferred.
2 context sentences(design, population, supporting numbers)
Summary · context
An IVF unit of an academic medical center.Fifty-two women who underwent controlled ovarian hyperstimulation and IVF.
Summary · context
Patients were prospectively randomized to receive 3.75 mg depot formulations of either leuprolide or triptorelin on days 21-23 of the menstrual cycle.
Report a problemFND-1247752304
05HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, fertilization rates did not differ significantly between triptorelin and leuprolide.
In plain wordsIn women undergoing IVF, fertilization rates did not differ significantly between triptorelin and leuprolide.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeFertilization rate
Study
n = 52
Comparator
Leuprolide acetate
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mg depotAs given in this study (human).
Source sentences
Summary
No significant differences were observed in the patient age, estrogen, and P levels on day of hCG administration, gonadotropin dosage, number of oocytes retrieved, fertilization rate, percentage of high-quality embryos, and number of embryos transferred.
2 context sentences(design, population, supporting numbers)
Summary · context
An IVF unit of an academic medical center.Fifty-two women who underwent controlled ovarian hyperstimulation and IVF.
Summary · context
Patients were prospectively randomized to receive 3.75 mg depot formulations of either leuprolide or triptorelin on days 21-23 of the menstrual cycle.
Report a problemFND-1247752305
06HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, high-quality embryo percentages did not differ significantly between triptorelin and leuprolide.
In plain wordsIn women undergoing IVF, high-quality embryo percentages did not differ significantly between triptorelin and leuprolide.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeHigh-quality embryos
Study
n = 52
Comparator
Leuprolide acetate
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mg depotAs given in this study (human).
Source sentences
Summary
No significant differences were observed in the patient age, estrogen, and P levels on day of hCG administration, gonadotropin dosage, number of oocytes retrieved, fertilization rate, percentage of high-quality embryos, and number of embryos transferred.
2 context sentences(design, population, supporting numbers)
Summary · context
An IVF unit of an academic medical center.Fifty-two women who underwent controlled ovarian hyperstimulation and IVF.
Summary · context
Patients were prospectively randomized to receive 3.75 mg depot formulations of either leuprolide or triptorelin on days 21-23 of the menstrual cycle.
Report a problemFND-1247752306
07HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, embryo transfer counts did not differ significantly between triptorelin and leuprolide.
In plain wordsIn women undergoing IVF, embryo transfer counts did not differ significantly between triptorelin and leuprolide.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeEmbryos transferred
Study
n = 52
Comparator
Leuprolide acetate
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mg depotAs given in this study (human).
Source sentences
Summary
No significant differences were observed in the patient age, estrogen, and P levels on day of hCG administration, gonadotropin dosage, number of oocytes retrieved, fertilization rate, percentage of high-quality embryos, and number of embryos transferred.
2 context sentences(design, population, supporting numbers)
Summary · context
An IVF unit of an academic medical center.Fifty-two women who underwent controlled ovarian hyperstimulation and IVF.
Summary · context
Patients were prospectively randomized to receive 3.75 mg depot formulations of either leuprolide or triptorelin on days 21-23 of the menstrual cycle.
Report a problemFND-1247752307
08HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, triptorelin produced lower clinical implantation rates than leuprolide.
In plain wordsIn women undergoing IVF, triptorelin produced lower clinical implantation rates than leuprolide.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseClinical implantation rate
Study
n = 52
Comparator
Leuprolide acetate
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mg depotAs given in this study (human).
Source sentences
Summary
However, significantly higher clinical implantation and pregnancy rates were found in the leuprolide group compared with the triptorelin group.
2 context sentences(design, population, supporting numbers)
Summary · context
An IVF unit of an academic medical center.Fifty-two women who underwent controlled ovarian hyperstimulation and IVF.
Summary · context
Patients were prospectively randomized to receive 3.75 mg depot formulations of either leuprolide or triptorelin on days 21-23 of the menstrual cycle.
Report a problemFND-1247752308
09HumanRandomized controlled trialEfficacy outcome
In women undergoing IVF, triptorelin produced lower pregnancy rates than leuprolide.
In plain wordsIn women undergoing IVF, triptorelin produced lower pregnancy rates than leuprolide.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreasePregnancy rate
Study
n = 52
Comparator
Leuprolide acetate
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mg depotAs given in this study (human).
Source sentences
Summary
However, significantly higher clinical implantation and pregnancy rates were found in the leuprolide group compared with the triptorelin group.
2 context sentences(design, population, supporting numbers)
Summary · context
An IVF unit of an academic medical center.Fifty-two women who underwent controlled ovarian hyperstimulation and IVF.
Summary · context
Patients were prospectively randomized to receive 3.75 mg depot formulations of either leuprolide or triptorelin on days 21-23 of the menstrual cycle.
Report a problemFND-1247752309

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:37 UTC
Study data updated · source update from Europe PMC
Version 2
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Comparison of leuprolide acetate and triptorelin in assisted reproductive technology cycles: a prospective, randomized study.

Summary

Results from this study9

Version history

Subjects

Publication types

MeSH terms