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Study · In vitro (cells) · 2002

3 results

The effect of thymosin beta4 on articular cartilage chondrocyte matrix metalloproteinase expression.

Blain EJ, Mason DJ, Duance VC

Biochemical Society transactions1 Nov 2002Cited by 22 (Europe PMC)

PMID12440937 (opens in a new tab)DOI10.1042/bst0300879 (opens in a new tab)PepBankPUB-12440937
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In primary articular chondrocytes, thymosin beta(4) peptide at 2 and 4 micro x ml(-1) for 4 h significantly increased pro-MMP 9 expression.

    In plain wordsIn cells, thymosin beta(4) peptide raised pro-MMP 9 expression in cartilage cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePro-MMP 9 expression in primary chondrocytes
    Study

    n: not reported in source

    primary chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    2 and 4 micro x ml(-1) · 4 hAs given in this study.

    Source sentences

    Summary
    Treatment of primary chondrocytes with 2 and 4 micro x ml(-1) thymosin beta(4) peptide for 4 h significantly increased pro-MMP 9 expression and activation.
    1 context sentence
    Summary · context
    The objective of this study was to confirm the mechanical regulation of thymosin beta(4) and determine its effect on cartilage chondrocyte MMP production.
  2. 02LabIn vitro (cells)Mechanism

    In primary articular chondrocytes, thymosin beta(4) peptide at 2 and 4 micro x ml(-1) for 4 h significantly increased pro-MMP 9 activation.

    In plain wordsIn cells, thymosin beta(4) peptide increased the activation of pro-MMP 9 in cartilage cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePro-MMP 9 activation in primary chondrocytes
    Study

    n: not reported in source

    primary chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    2 and 4 micro x ml(-1) · 4 hAs given in this study.

    Source sentences

    Summary
    Treatment of primary chondrocytes with 2 and 4 micro x ml(-1) thymosin beta(4) peptide for 4 h significantly increased pro-MMP 9 expression and activation.
    1 context sentence
    Summary · context
    The objective of this study was to confirm the mechanical regulation of thymosin beta(4) and determine its effect on cartilage chondrocyte MMP production.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03LabEndogenous levelEx vivo tissueMechanism

    In articular cartilage, mechanical loading for 10 min caused a significant 20-fold increase in thymosin beta(4) mRNA expression, still evident after 30 min of loading.

    In plain wordsIn cartilage tissue, mechanical loading raised the tissue's own thymosin beta(4) mRNA about 20-fold.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta(4) mRNA expression in loaded articular cartilage
    Study

    n: not reported in source

    articular cartilage under mechanical loading
    Outcome group
    Bone and joint · Musculoskeletal

    Measurements

    Thymosin beta(4) mRNA fold change
    20-fold
    cartilage loaded for 10 min

    Source sentences

    Summary
    Thymosin beta(4) mRNA expression, analysed by quantitative PCR, revealed a significant 20-fold increase in cartilage loaded for 10 min which was still evident after 30 min of loading.
    1 context sentence
    Summary · context
    The objective of this study was to confirm the mechanical regulation of thymosin beta(4) and determine its effect on cartilage chondrocyte MMP production.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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