Study · Animal study (in vivo) · rat · 2002
16 resultsHorvath JE, Bajo AM, Schally AV, Kovacs M, Herbert F, Groot K
Proceedings of the National Academy of Sciences of the United States of America30 Oct 2002Cited by 27 (Europe PMC)
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Text rights: Publisher copyright. Results still quote short attributed sentences.
14 results from studies that gave the peptide. No result from this study comes from people.
In female rats, Decapeptyl microcapsules increased serum LH.
In plain wordsIn female rats, Decapeptyl microcapsules increased serum LH.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
Decapeptyl microcapsules elevated serum LH in female rats, but decreased it in male rats.
In male rats, Decapeptyl microcapsules decreased serum LH.
In plain wordsIn male rats, Decapeptyl microcapsules decreased serum LH.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
Decapeptyl microcapsules elevated serum LH in female rats, but decreased it in male rats.
In female rats, Decapeptyl microcapsules reduced pituitary LHRH receptor mRNA to 41% on day 10 and 56-65% on day 30.
In plain wordsIn female rats, Decapeptyl microcapsules reduced pituitary receptor gene expression on days 10 and 30.
ratn: not reported in source
Pituitary-gonadal axisMeasurements
Source sentences
LHRH-R mRNA expression in female pituitaries was reduced to 41% and 56-65% on days 10 and 30, respectively, whereas LHRH-R protein was 64% of control on day 10 and returned to pretreatment levels on day 30.
Decapeptyl microcapsules elevated serum LH in female rats, but decreased it in male rats.
The effects of depot formulations of the luteinizing hormone-releasing hormone (LHRH) agonist Decapeptyl (25 microg/day) for 30 days or LHRH antagonist Cetrorelix pamoate (100 microg/day) for 30 days and daily injections of 100 microg of Decapeptyl for 10 days on the expression of mRNA for pituitary…
In female rats, Decapeptyl microcapsules reduced pituitary LHRH receptor protein to 64% of control on day 10.
In plain wordsIn female rats, Decapeptyl microcapsules reduced pituitary receptor protein compared with control on day 10.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
LHRH-R mRNA expression in female pituitaries was reduced to 41% and 56-65% on days 10 and 30, respectively, whereas LHRH-R protein was 64% of control on day 10 and returned to pretreatment levels on day 30.
Decapeptyl microcapsules elevated serum LH in female rats, but decreased it in male rats.
The effects of depot formulations of the luteinizing hormone-releasing hormone (LHRH) agonist Decapeptyl (25 microg/day) for 30 days or LHRH antagonist Cetrorelix pamoate (100 microg/day) for 30 days and daily injections of 100 microg of Decapeptyl for 10 days on the expression of mRNA for pituitary…
In female rats, pituitary LHRH receptor protein returned to pretreatment levels on day 30 during Decapeptyl microcapsule treatment.
In plain wordsIn female rats, pituitary receptor protein returned to pretreatment levels on day 30 during Decapeptyl microcapsule treatment.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
LHRH-R mRNA expression in female pituitaries was reduced to 41% and 56-65% on days 10 and 30, respectively, whereas LHRH-R protein was 64% of control on day 10 and returned to pretreatment levels on day 30.
Decapeptyl microcapsules elevated serum LH in female rats, but decreased it in male rats.
The effects of depot formulations of the luteinizing hormone-releasing hormone (LHRH) agonist Decapeptyl (25 microg/day) for 30 days or LHRH antagonist Cetrorelix pamoate (100 microg/day) for 30 days and daily injections of 100 microg of Decapeptyl for 10 days on the expression of mRNA for pituitary…
In male rats, Decapeptyl microcapsules reduced pituitary receptor mRNA to 58% on day 30.
In plain wordsIn male rats, Decapeptyl microcapsules reduced pituitary receptor gene expression on day 30.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
Decapeptyl microcapsules reduced LHRH-R mRNA expression in male pituitaries to 58% on day 30 but not LHRH-R protein.
In male rats, Decapeptyl microcapsules did not reduce pituitary receptor protein.
In plain wordsIn male rats, Decapeptyl microcapsules did not reduce pituitary receptor protein.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
Decapeptyl microcapsules reduced LHRH-R mRNA expression in male pituitaries to 58% on day 30 but not LHRH-R protein.
In female rats, daily Decapeptyl injections desensitized LH responses.
In plain wordsIn female rats, daily Decapeptyl injections reduced LH responsiveness.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
Daily injections of Decapeptyl caused a desensitization of LH responses in female rats, while raising LHRH-R mRNA expression in female rats by 23% and LHRH-R protein levels by 119%.
In female rats, daily Decapeptyl injections increased receptor mRNA expression by 23%.
In plain wordsIn female rats, daily Decapeptyl injections increased receptor gene expression by 23%.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
Daily injections of Decapeptyl caused a desensitization of LH responses in female rats, while raising LHRH-R mRNA expression in female rats by 23% and LHRH-R protein levels by 119%.
In female rats, daily Decapeptyl injections increased receptor protein by 119%.
In plain wordsIn female rats, daily Decapeptyl injections increased receptor protein by 119%.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
Daily injections of Decapeptyl caused a desensitization of LH responses in female rats, while raising LHRH-R mRNA expression in female rats by 23% and LHRH-R protein levels by 119%.
In ovariectomized rats, Decapeptyl reduced elevated receptor protein levels.
In plain wordsIn ovariectomized rats, Decapeptyl reduced elevated receptor protein levels.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
Elevated LHRH-R protein levels of ovariectomized rats were reduced after 10-day treatment with Cetrorelix or 100 microg/day Decapeptyl.
In rats, Decapeptyl inhibited serum LH less than cetrorelix.
In plain wordsIn rats, Decapeptyl reduced serum LH less than cetrorelix.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
The inhibitory effect of Cetrorelix on serum LH, pituitary LHRH-R mRNA, and LHRH-R protein was greater than that of Decapeptyl.
In rats, Decapeptyl inhibited pituitary receptor mRNA less than cetrorelix.
In plain wordsIn rats, Decapeptyl reduced pituitary receptor gene expression less than cetrorelix.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
The inhibitory effect of Cetrorelix on serum LH, pituitary LHRH-R mRNA, and LHRH-R protein was greater than that of Decapeptyl.
In rats, Decapeptyl inhibited receptor protein less than cetrorelix.
In plain wordsIn rats, Decapeptyl reduced receptor protein less than cetrorelix.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
The inhibitory effect of Cetrorelix on serum LH, pituitary LHRH-R mRNA, and LHRH-R protein was greater than that of Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).
In rats, sex steroid concentrations decreased in all analog-treated groups, including Decapeptyl groups.
In plain wordsIn rats, sex steroid levels decreased in all analog-treated groups, including Decapeptyl groups.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
Serum sex steroid concentrations and the weights of the reproductive organs were greatly reduced in all groups treated with analogs, demonstrating an efficient blockade of the pituitary-gonadal axis.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
In rats, reproductive organ weights decreased in all analog-treated groups, including Decapeptyl groups.
In plain wordsIn rats, reproductive organ weights decreased in all analog-treated groups, including Decapeptyl groups.
ratn: not reported in source
Pituitary-gonadal axisSource sentences
Serum sex steroid concentrations and the weights of the reproductive organs were greatly reduced in all groups treated with analogs, demonstrating an efficient blockade of the pituitary-gonadal axis.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
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Version 3Current
27 Oct 2026, 16:35 UTC
Study data updated · source update from Europe PMC
Version 2
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC
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