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Study · Ex vivo tissue · cattle and pig · 2002

4 results

Growth hormone secretagogue (GHS) analogue, hexarelin stimulates GH from peripheral lymphocytes.

Poppi L, Dixit VD, Baratta M, Giustina A, Tamanini C, Parvizi N

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association1 Oct 2002Cited by 13 (Europe PMC)

PMID12397533 (opens in a new tab)DOI10.1055/s-2002-34991 (opens in a new tab)PepBankPUB-12397533
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In porcine blood mononuclear cells, hexarelin increased basal GH secretion nearly two fold.

    In plain wordsIn pig blood cells in a dish, hexarelin raised growth hormone release to nearly twice the basal level.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH secretion from porcine lymphocytes
    Study

    pign: not reported in source

    blood mononuclear cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.1, 1.0, 10 and 100 nM · 3 or 5 daysAs given in this study (pig).

    Measurements

    GH secretion
    3.5 ng/ml
    porcine cells

    Source sentences

    Summary
    A nearly two fold increase in basal secretion of GH (porcine: 3.5 +/- 0.1 ng/ml, bovine: 3.2 +/- 0.2 ng/ml) was achieved by GHRH and hexarelin at concentrations of 0.1, 1.0, 10 and 100 nM in both porcine and bovine cells.
    2 context sentences
    Summary · context
    Porcine and bovine blood mononuclear cells were separated using density gradient centrifugation method by layering the whole blood or buffy coat cells on lymphodex.
    Summary · context
    Cells were incubated for 3 or 5 days with or without phytohemagglutinin (PHA-M), GHRH, GHRP-6 analogue hexarelin, somatostatin or GHRH + hexarelin.
  2. 02LabEx vivo tissueActivity measurement

    In bovine blood mononuclear cells, hexarelin increased basal GH secretion nearly two fold.

    In plain wordsIn cattle blood cells in a dish, hexarelin raised growth hormone release to nearly twice the basal level.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH secretion from bovine lymphocytes
    Study

    cattlen: not reported in source

    blood mononuclear cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.1, 1.0, 10 and 100 nM · 3 or 5 daysAs given in this study (cattle).

    Measurements

    GH secretion
    3.2 ng/ml
    bovine cells

    Source sentences

    Summary
    A nearly two fold increase in basal secretion of GH (porcine: 3.5 +/- 0.1 ng/ml, bovine: 3.2 +/- 0.2 ng/ml) was achieved by GHRH and hexarelin at concentrations of 0.1, 1.0, 10 and 100 nM in both porcine and bovine cells.
    2 context sentences
    Summary · context
    Porcine and bovine blood mononuclear cells were separated using density gradient centrifugation method by layering the whole blood or buffy coat cells on lymphodex.
    Summary · context
    Cells were incubated for 3 or 5 days with or without phytohemagglutinin (PHA-M), GHRH, GHRP-6 analogue hexarelin, somatostatin or GHRH + hexarelin.
  3. 03LabEx vivo tissueActivity measurement

    In porcine and bovine blood mononuclear cells, hexarelin did not produce a dose-dependent effect on GH secretion.

    In plain wordsIn pig and cattle blood cells in a dish, higher hexarelin doses did not raise growth hormone release further.

    Peptide
    Hexarelin
    Outcome
    No significant changeDose dependence of GH secretion
    Study

    pig, cattlen: not reported in source

    blood mononuclear cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.1, 1.0, 10 and 100 nM · 3 or 5 daysAs given in this study (pig, cattle).

    Source sentences

    Summary
    Neither a dose dependent nor a synergistic nor an additive effect was apparent on GH secretion from lymphocytes.
    2 context sentences
    Summary · context
    Cells were incubated for 3 or 5 days with or without phytohemagglutinin (PHA-M), GHRH, GHRP-6 analogue hexarelin, somatostatin or GHRH + hexarelin.
    Summary · context
    Porcine and bovine blood mononuclear cells were separated using density gradient centrifugation method by layering the whole blood or buffy coat cells on lymphodex.

Studies that did not test the peptide alone1

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 04LabNot a test of Hexarelin aloneEx vivo tissueActivity measurement

    In porcine and bovine blood mononuclear cells, GHRH plus hexarelin did not give a synergistic or additive effect on GH secretion.

    In plain wordsIn pig and cattle blood cells in a dish, hexarelin plus GHRH did not raise growth hormone release more than either alone.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH secretion with GHRH plus hexarelin
    Study

    pig, cattlen: not reported in source

    blood mononuclear cells
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Neither a dose dependent nor a synergistic nor an additive effect was apparent on GH secretion from lymphocytes.
    2 context sentences
    Summary · context
    Cells were incubated for 3 or 5 days with or without phytohemagglutinin (PHA-M), GHRH, GHRP-6 analogue hexarelin, somatostatin or GHRH + hexarelin.
    Summary · context
    Porcine and bovine blood mononuclear cells were separated using density gradient centrifugation method by layering the whole blood or buffy coat cells on lymphodex.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 2

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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