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Study · Animal study (in vivo) · rat · 2003

12 results

Correction of age-related polyuria by dDAVP: molecular analysis of aquaporins and urea transporters.

Combet S, Geffroy N, Berthonaud V, Dick B, Teillet L, Verbavatz JM, Corman B, Trinh-Trang-Tan MM

American journal of physiology. Renal physiology13 Aug 2002Cited by 36 (Europe PMC)

PMID12388383 (opens in a new tab)DOI10.1152/ajprenal.00167.2002 (opens in a new tab)PepBankPUB-12388383
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In senescent rats, long-term dDAVP infusion reduced urine flow to levels comparable to control adult rats.

    In plain wordsIn senescent rats, dDAVP reduced urine flow to levels comparable to control adult rats.

    Peptide
    Desmopressin
    Outcome
    DecreaseUrine flow rate
    Study

    ratn: not reported in source

    Senescent female WAG/Rij rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    Long-term dDAVP infusion into 30-mo-old rats reduced urine flow rate and increased urine osmolality to levels comparable to those in control 10-mo-old rats.
    2 context sentences
    Summary · context
    Senescent female WAG/Rij rats exhibit polyuria without obvious renal disease or defects in vasopressin plasma level or V(2) receptor mRNA expression.
    Summary · context
    Normalization of urine flow rate by 1-desamino-8-d-arginine vasopressin (dDAVP) was investigated in these animals.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In senescent rats, long-term dDAVP infusion increased urine osmolality to levels comparable to control adult rats.

    In plain wordsIn senescent rats, dDAVP increased urine concentration to levels comparable to control adult rats.

    Peptide
    Desmopressin
    Outcome
    IncreaseUrine osmolality
    Study

    ratn: not reported in source

    Senescent female WAG/Rij rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    Long-term dDAVP infusion into 30-mo-old rats reduced urine flow rate and increased urine osmolality to levels comparable to those in control 10-mo-old rats.
    2 context sentences
    Summary · context
    Senescent female WAG/Rij rats exhibit polyuria without obvious renal disease or defects in vasopressin plasma level or V(2) receptor mRNA expression.
    Summary · context
    Normalization of urine flow rate by 1-desamino-8-d-arginine vasopressin (dDAVP) was investigated in these animals.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In aging rats, maximal urine osmolality remained below adult levels despite supramaximal dDAVP administration.

    In plain wordsIn aging rats, maximal urine concentration remained below adult levels despite supramaximal dDAVP administration.

    Peptide
    Desmopressin
    Outcome
    Not applicableMaximal urine osmolality
    Study

    ratn: not reported in source

    Senescent female WAG/Rij rats
    Comparator
    Adult kidney
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    The maximal urine osmolality in aging rat kidney was, however, lower than that in adult kidney, despite supramaximal administration of dDAVP.
    2 context sentences
    Summary · context
    Senescent female WAG/Rij rats exhibit polyuria without obvious renal disease or defects in vasopressin plasma level or V(2) receptor mRNA expression.
    Summary · context
    Normalization of urine flow rate by 1-desamino-8-d-arginine vasopressin (dDAVP) was investigated in these animals.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In senescent rats, improvement with dDAVP involved increased inner medullary osmolality.

    In plain wordsIn senescent rats, improvement with dDAVP involved increased inner medullary osmolality.

    Peptide
    Desmopressin
    Outcome
    IncreaseInner medullary osmolality
    Study

    ratn: not reported in source

    Senescent female WAG/Rij rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    This improvement involved increased inner medullary osmolality and urea sequestration.
    2 context sentences
    Summary · context
    Senescent female WAG/Rij rats exhibit polyuria without obvious renal disease or defects in vasopressin plasma level or V(2) receptor mRNA expression.
    Summary · context
    Normalization of urine flow rate by 1-desamino-8-d-arginine vasopressin (dDAVP) was investigated in these animals.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In senescent rats, improvement with dDAVP involved increased urea sequestration.

    In plain wordsIn senescent rats, improvement with dDAVP involved increased urea retention in the kidney.

    Peptide
    Desmopressin
    Outcome
    IncreaseUrea sequestration
    Study

    ratn: not reported in source

    Senescent female WAG/Rij rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    This improvement involved increased inner medullary osmolality and urea sequestration.
    2 context sentences
    Summary · context
    Senescent female WAG/Rij rats exhibit polyuria without obvious renal disease or defects in vasopressin plasma level or V(2) receptor mRNA expression.
    Summary · context
    Normalization of urine flow rate by 1-desamino-8-d-arginine vasopressin (dDAVP) was investigated in these animals.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In senescent rats, improvement with dDAVP may reflect UT-A1 upregulation in initial IMCD.

    In plain wordsIn senescent rats, improvement with dDAVP may reflect increased UT-A1 in initial IMCD.

    Peptide
    Desmopressin
    Outcome
    IncreaseUT-A1 in initial IMCD
    Study

    ratn: not reported in source

    Senescent female WAG/Rij rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    This may result from upregulation of UT-A1, the vasopressin-regulated urea transporter, in initial inner medullary collecting duct (IMCD), but not in terminal IMCD, where UT-A1 remained low.
    2 context sentences
    Summary · context
    Senescent female WAG/Rij rats exhibit polyuria without obvious renal disease or defects in vasopressin plasma level or V(2) receptor mRNA expression.
    Summary · context
    Normalization of urine flow rate by 1-desamino-8-d-arginine vasopressin (dDAVP) was investigated in these animals.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In senescent rats given dDAVP, UT-A1 remained low in terminal IMCD.

    In plain wordsIn senescent rats given dDAVP, UT-A1 remained low in terminal IMCD.

    Peptide
    Desmopressin
    Outcome
    No significant changeUT-A1 in terminal IMCD
    Study

    ratn: not reported in source

    Senescent female WAG/Rij rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    This may result from upregulation of UT-A1, the vasopressin-regulated urea transporter, in initial inner medullary collecting duct (IMCD), but not in terminal IMCD, where UT-A1 remained low.
    2 context sentences
    Summary · context
    Senescent female WAG/Rij rats exhibit polyuria without obvious renal disease or defects in vasopressin plasma level or V(2) receptor mRNA expression.
    Summary · context
    Normalization of urine flow rate by 1-desamino-8-d-arginine vasopressin (dDAVP) was investigated in these animals.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In senescent rats given dDAVP, UT-A2 expression greatly increased.

    In plain wordsIn senescent rats given dDAVP, UT-A2 expression greatly increased.

    Peptide
    Desmopressin
    Outcome
    IncreaseUT-A2 expression
    Study

    ratn: not reported in source

    Senescent female WAG/Rij rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    Expression of UT-A2, which contributes to medullary urea recycling, was greatly increased.
    2 context sentences
    Summary · context
    Senescent female WAG/Rij rats exhibit polyuria without obvious renal disease or defects in vasopressin plasma level or V(2) receptor mRNA expression.
    Summary · context
    Normalization of urine flow rate by 1-desamino-8-d-arginine vasopressin (dDAVP) was investigated in these animals.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In senescent rats, dDAVP infusion normalized low AQP2 abundance.

    In plain wordsIn senescent rats, dDAVP restored low AQP2 levels to normal.

    Peptide
    Desmopressin
    Outcome
    IncreaseAQP2 abundance in senescent rats
    Study

    ratn: not reported in source

    Senescent female WAG/Rij rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    the low AQP2 abundance in senescent rats was normalized by dDAVP infusion, which also improved targeting of the channel;
    2 context sentences
    Summary · context
    Senescent female WAG/Rij rats exhibit polyuria without obvious renal disease or defects in vasopressin plasma level or V(2) receptor mRNA expression.
    Summary · context
    Normalization of urine flow rate by 1-desamino-8-d-arginine vasopressin (dDAVP) was investigated in these animals.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In senescent rats, dDAVP infusion improved AQP2 targeting.

    In plain wordsIn senescent rats, dDAVP improved AQP2 targeting.

    Peptide
    Desmopressin
    Outcome
    IncreaseAQP2 targeting
    Study

    ratn: not reported in source

    Senescent female WAG/Rij rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    the low AQP2 abundance in senescent rats was normalized by dDAVP infusion, which also improved targeting of the channel;
    2 context sentences
    Summary · context
    Senescent female WAG/Rij rats exhibit polyuria without obvious renal disease or defects in vasopressin plasma level or V(2) receptor mRNA expression.
    Summary · context
    Normalization of urine flow rate by 1-desamino-8-d-arginine vasopressin (dDAVP) was investigated in these animals.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In adult rats, dDAVP did not alter AQP2 expression.

    In plain wordsIn adult rats, dDAVP did not alter AQP2 expression.

    Peptide
    Desmopressin
    Outcome
    No significant changeAQP2 expression in adult rats
    Study

    ratn: not reported in source

    Adult rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    in adult rats, AQP2 expression was unaltered, suggesting that IMCD AQP2 expression is not regulated by dDAVP directly.
    2 context sentences
    Summary · context
    Senescent female WAG/Rij rats exhibit polyuria without obvious renal disease or defects in vasopressin plasma level or V(2) receptor mRNA expression.
    Summary · context
    Normalization of urine flow rate by 1-desamino-8-d-arginine vasopressin (dDAVP) was investigated in these animals.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In senescent rats given dDAVP, increased AQP3 expression may contribute to improved urine-concentrating capacity.

    In plain wordsIn senescent rats given dDAVP, increased AQP3 expression may help the kidneys concentrate urine.

    Peptide
    Desmopressin
    Outcome
    IncreaseAQP3 expression
    Study

    ratn: not reported in source

    Senescent female WAG/Rij rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · infusionAs given in this study (rat).

    Source sentences

    Summary
    Increased AQP3 expression in senescent rats may also be involved in improved urine-concentrating capacity owing to higher basolateral water and urea reabsorption capacity.
    2 context sentences
    Summary · context
    Senescent female WAG/Rij rats exhibit polyuria without obvious renal disease or defects in vasopressin plasma level or V(2) receptor mRNA expression.
    Summary · context
    Normalization of urine flow rate by 1-desamino-8-d-arginine vasopressin (dDAVP) was investigated in these animals.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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