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Study · In vitro (cells) · 2002

3 results

Thymosin beta4 promotes human conjunctival epithelial cell migration.

Sosne G, Hafeez S, Greenberry AL 2nd, Kurpakus-Wheater M

Current eye research1 Apr 2002Cited by 49 (Europe PMC)

PMID12324865 (opens in a new tab)DOI10.1076/ceyr.24.4.268.8414 (opens in a new tab)PepBankPUB-12324865
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human conjunctival epithelial cells, thymosin beta4 stimulated cell migration in a dose-dependent manner.

    In plain wordsIn cells, thymosin beta4 made human eye-surface cells move more, and the effect grew with the dose.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseConjunctival epithelial cell migration
    Study

    humann: not reported in source

    human conjunctival cell line HC0597
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tbeta4 stimulated migration in a dose-dependent manner.
    2 context sentences
    Summary · context
    Boyden chamber assays assessed the ability of Tbeta4 to stimulate in vitro cell migration.
    Summary · context
    In this study the effects of thymosin beta4 (Tbeta4) on migration and production of laminin-5 in the human conjunctival cell line HC0597 was analyzed.
  2. 02LabIn vitro (cells)Mechanism

    In human conjunctival cells, thymosin beta4 treatment produced focal adhesions that were smaller and more rounded than the streaks seen in control cells.

    In plain wordsIn cells, thymosin beta4 made the cells' attachment points smaller and rounder compared with control cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableFocal adhesion morphology
    Study

    humann: not reported in source

    human conjunctival cell line HC0597
    Comparator
    Control cells
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Focal adhesions present in Tbeta4-treated cells were smaller and more rounded compared to the "streaks" characteristic of controls.
    1 context sentence
    Summary · context
    In this study the effects of thymosin beta4 (Tbeta4) on migration and production of laminin-5 in the human conjunctival cell line HC0597 was analyzed.
  3. 03LabIn vitro (cells)Mechanism

    In human conjunctival cells, thymosin beta4 treatment increased laminin-5 alpha3 and gamma2 chain protein compared with control cells.

    In plain wordsIn cells, thymosin beta4 raised the amount of laminin-5 protein compared with control cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseLaminin-5 alpha3 and gamma2 chain protein
    Study

    humann: not reported in source

    human conjunctival cell line HC0597
    Comparator
    Control cells
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Western blot analysis and densitometry revealed that Tbeta4-treated cells expressed more laminin-5 alpha3 and gamma2 chain protein.
    1 context sentence
    Summary · context
    In this study the effects of thymosin beta4 (Tbeta4) on migration and production of laminin-5 in the human conjunctival cell line HC0597 was analyzed.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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