Effects of interleukin-1-beta, interleukin-6 and tumor necrosis factor-alpha, alone or in association with hexarelin or galanin, on growth hormone gene expression and growth hormone release from pig pituitary cells.

Mainardi GL, Saleri R, Tamanini C, Baratta M

Hormone research1 Jan 2002Cited by 19 (Europe PMC)

PMID12324716DOI10.1159/000065487PepBankPUB-12324716

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

01LabNot a test of Hexarelin aloneIn vitro (cells)Efficacy outcome
In pig pituitary cells, IL-6 at 10 ng/ml potentiated the GH secretion induced by galanin and by hexarelin.
In plain wordsIn pig pituitary cells, IL-6 boosted the growth hormone release triggered by galanin and hexarelin.
Peptide
Hexarelin
Outcome
IncreaseGH secretion with hexarelin or galanin plus IL-6
Study
pign: not reported in source
Primary adult pig pituitary cells
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
IL-6 (10 ng/ml) potentiated the effect of both GH releasers (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Pituitary cells from adult pigs were treated with IL-1beta, IL-6 or TNF-alpha (1, 10 and 100 ng/ml), alone or in association with galanin or hexarelin (10(-8) M): GH mRNA was measured by RT-PCR and GH secretion by ELISA.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-1232471601
02LabNot a test of Hexarelin aloneIn vitro (cells)Mechanism
In pig pituitary cells, IL-6 at 1 and 10 ng/ml increased GH gene expression, alone or together with galanin and hexarelin.
In plain wordsIn pig pituitary cells, IL-6 raised growth hormone gene activity, alone or with galanin and hexarelin.
Peptide
Hexarelin
Outcome
IncreaseGH gene expression with IL-6 plus hexarelin or galanin
Study
pign: not reported in source
Primary adult pig pituitary cells
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
GH gene expression was increased only by IL-6 at the concentrations of 1 and 10 ng/ml, either alone or in association with both galanin and hexarelin.
1 context sentence(design, population, supporting numbers)
Summary · context
Pituitary cells from adult pigs were treated with IL-1beta, IL-6 or TNF-alpha (1, 10 and 100 ng/ml), alone or in association with galanin or hexarelin (10(-8) M): GH mRNA was measured by RT-PCR and GH secretion by ELISA.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-1232471602

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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