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Study · In vitro (cells) · rat · 2002

1 result

The neuropeptide PACAP attenuates beta-amyloid (1-42)-induced toxicity in PC12 cells.

Onoue S, Endo K, Ohshima K, Yajima T, Kashimoto K

Peptides1 Aug 2002Cited by 88 (Europe PMC)

PMID12182949 (opens in a new tab)DOI10.1016/s0196-9781(02)00085-2 (opens in a new tab)PepBankPUB-12182949
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In PC12 cells exposed to Abeta, humanin was much less effective than PACAP.

    In plain wordsIn cells, humanin was far less effective than PACAP at protecting nerve-like cells from amyloid-beta toxicity.

    Peptide
    Humanin
    Outcome
    Direction not reportedAbeta-induced toxicity in PC12 cells (relative potency)
    Study

    ratn: not reported in source

    PC12 cells
    Comparator
    PACAP
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PACAP was at least 10(4)-fold more effective than other neuropeptides including vasoactive intestinal peptide (VIP) and humanin, which correlated with the level of cAMP accumulation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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