In an ALK-positive anaplastic large cell lymphoma line, thymosin beta4 was among the genes differentially expressed and upregulated compared with an ALK-negative case.
In plain wordsIn lymphoma cells, the cells' own thymosin beta4 gene was among genes at higher levels than in an ALK-negative case.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- IncreaseThymosin beta4 gene expression in ALK-positive lymphoma cells
- Study
humann: not reported in source
ALK-positive anaplastic large cell lymphoma cell line versus ALK-negative ALCL clinical case- Comparator
- ALK-negative ALCL clinical case
- Outcome group
- Receptor activity and mechanism · Cancer
Source sentences
Most of these clones corresponded to novel genes with unknown function (EST) or to genes implicated in the differentiation, activation or signalling of T cells such as Ran/TC4, interleukin 1-receptor, thymosin beta4, thymosin beta10, moesin and cytohesin-1.
1 context sentence(design, population, supporting numbers)
Overall, our results suggest that all the genes described above are upregulated in the NPM-ALK-driven transformation process, and that moesin and cytohesin-1 may be more specifically implicated in a signalling pathway involving PLCgamma and PI3K.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.