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Study · Animal study (in vivo) · rat · 2002

10 results

Influence of chronic treatment with the growth hormone secretagogue Ipamorelin, in young female rats: somatotroph response in vitro.

Jiménez-Reina L, Cañete R, de la Torre MJ, Bernal G

Histology and histopathology1 Jan 2002Cited by 2 (Europe PMC)

PMID12168778 (opens in a new tab)DOI10.14670/hh-17.707 (opens in a new tab)PepBankPUB-12168778
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In young female rats treated for 21 days, Ipamorelin did not change the ultrastructure of pituitary somatotroph cells.

    In plain wordsIn rats, 21 days of Ipamorelin treatment did not change the structure of growth hormone cells in the pituitary.

    Peptide
    Ipamorelin
    Outcome
    No significant changeSomatotroph ultrastructure
    Study

    ratn: not reported in source

    Pituitary cell cultures from young female rats treated in vivo
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    The ultrastructure of somatotroph cells did not change
    1 context sentence
    Summary · context
    in pituitary cell cultures obtained from young female rats receiving Ipamorelin over 21 days (Ipamorelin group) and the effects were compared with those of GHRH (GHRH group) or saline (saline group).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In young female rats, previous in vivo Ipamorelin treatment increased the volume density of secretion granules in somatotroph cells (P<0.05).

    In plain wordsIn rats, earlier Ipamorelin treatment increased the share of cell volume taken by hormone storage granules in growth hormone cells.

    Peptide
    Ipamorelin
    Outcome
    IncreaseVolume density of secretion granules
    Study

    ratn: not reported in source

    Pituitary cell cultures from young female rats treated in vivo
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    the volume density of secretion granules was increased (P<0.05) by previous in vivo Ipamorelin or GHRH treatment.
    1 context sentence
    Summary · context
    in pituitary cell cultures obtained from young female rats receiving Ipamorelin over 21 days (Ipamorelin group) and the effects were compared with those of GHRH (GHRH group) or saline (saline group).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In 3-day basal pituitary cultures from rats treated with Ipamorelin, the percentage of somatotroph cells did not differ between groups.

    In plain wordsIn rats, 21 days of Ipamorelin treatment did not change the percentage of growth hormone cells in basal pituitary cultures.

    Peptide
    Ipamorelin
    Outcome
    No significant changePercentage of somatotroph cells in basal cultures
    Study

    ratn: not reported in source

    Pituitary cell cultures from young female rats treated in vivo
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    the percentage of somatotroph cells showed no modifications between groups
    1 context sentence
    Summary · context
    in pituitary cell cultures obtained from young female rats receiving Ipamorelin over 21 days (Ipamorelin group) and the effects were compared with those of GHRH (GHRH group) or saline (saline group).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In 3-day basal pituitary cultures from rats treated with Ipamorelin, the ratio of strongly to weakly immunostaining GH cells did not change.

    In plain wordsIn rats, 21 days of Ipamorelin treatment did not change the ratio of strongly to weakly staining growth hormone cells.

    Peptide
    Ipamorelin
    Outcome
    No significant changeRatio of strongly to weakly GH-immunostaining cells in basal cultures
    Study

    ratn: not reported in source

    Pituitary cell cultures from young female rats treated in vivo
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    nor was there any change in the ratio of strongly/weakly immunostaining GH cells.
    1 context sentence
    Summary · context
    in pituitary cell cultures obtained from young female rats receiving Ipamorelin over 21 days (Ipamorelin group) and the effects were compared with those of GHRH (GHRH group) or saline (saline group).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In pituitary cultures from rats pretreated with Ipamorelin, 4 hours of in vitro Ipamorelin (10(-8) M) increased the percentage of somatotroph cells.

    In plain wordsIn cells from rats pretreated with Ipamorelin, adding Ipamorelin in the dish raised the percentage of growth hormone cells.

    Peptide
    Ipamorelin
    Outcome
    IncreasePercentage of somatotroph cells after in vitro Ipamorelin
    Study

    ratn: not reported in source

    Pituitary cell cultures from young female rats treated in vivo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-8) M · 4 hoursAs given in this study (rat).

    Source sentences

    Summary
    In the Ipamorelin group alone, in vitro treatment with Ipamorelin (10(-8) M), or GHRP 6 (10(-8) M), or GHRH (10(-8) M) for 4 hours, increased the percentage of somatotroph cells
    1 context sentence
    Summary · context
    in pituitary cell cultures obtained from young female rats receiving Ipamorelin over 21 days (Ipamorelin group) and the effects were compared with those of GHRH (GHRH group) or saline (saline group).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In pituitary cultures from rats pretreated with Ipamorelin, in vitro Ipamorelin (10(-8) M) did not change the ratio of strongly to weakly immunostained GH cells.

    In plain wordsIn cells from rats pretreated with Ipamorelin, adding Ipamorelin in the dish did not change the ratio of strongly to weakly staining cells.

    Peptide
    Ipamorelin
    Outcome
    No significant changeRatio of strongly to weakly GH-immunostained cells after in vitro Ipamorelin
    Study

    ratn: not reported in source

    Pituitary cell cultures from young female rats treated in vivo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-8) M · 4 hoursAs given in this study (rat).

    Source sentences

    Summary
    without modifying the ratio of strongly/weakly immunostained GH cells.
    1 context sentence
    Summary · context
    in pituitary cell cultures obtained from young female rats receiving Ipamorelin over 21 days (Ipamorelin group) and the effects were compared with those of GHRH (GHRH group) or saline (saline group).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats treated with Ipamorelin for 21 days, basal intracellular GH content of somatotroph cells over 4 hours was lower than in saline-treated rats.

    In plain wordsIn rats, Ipamorelin treatment lowered the basal growth hormone content inside pituitary cells compared with saline.

    Peptide
    Ipamorelin
    Outcome
    DecreaseBasal intracellular GH content in somatotroph cells
    Study

    ratn: not reported in source

    Pituitary cell cultures from young female rats treated in vivo
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    Basal intracellular GH content in somatotroph cells over 4 hours was lower in the Ipamorelin group and the GHRH group than in the saline group.
    1 context sentence
    Summary · context
    in pituitary cell cultures obtained from young female rats receiving Ipamorelin over 21 days (Ipamorelin group) and the effects were compared with those of GHRH (GHRH group) or saline (saline group).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In pituitary cultures from rats pretreated with Ipamorelin, in vitro Ipamorelin (10(-8) M) increased intracellular GH content.

    In plain wordsIn cells from rats pretreated with Ipamorelin, adding Ipamorelin in the dish raised the growth hormone content inside the cells.

    Peptide
    Ipamorelin
    Outcome
    IncreaseIntracellular GH content after in vitro Ipamorelin
    Study

    ratn: not reported in source

    Pituitary cell cultures from young female rats treated in vivo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-8) M · 4 hoursAs given in this study (rat).

    Source sentences

    Summary
    Only in the Ipamorelin group did Ipamorelin (10(-8) M), GHRP 6 (10(-8) M) and GHRH (10(-8) M) prompt increased intracellular GH content.
    1 context sentence
    Summary · context
    in pituitary cell cultures obtained from young female rats receiving Ipamorelin over 21 days (Ipamorelin group) and the effects were compared with those of GHRH (GHRH group) or saline (saline group).
  9. 09LabEx vivo tissueEfficacy outcome

    In pituitary cell cultures from rats pretreated with ipamorelin, 4 hours of in vitro GHRP‑6 treatment increased the percentage of somatotroph cells.

    In plain wordsIn rat pituitary cell cultures, GHRP‑6 increased the share of growth hormone-producing cells, only in cells from rats pretreated with ipamorelin.

    Peptide
    GHRP-6
    Outcome
    IncreasePercentage of somatotroph cells
    Study

    ratn: not reported in source

    primary pituitary cell cultures from young female rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10^-8 M · 4 hoursAs given in this study (rat).

    Source sentences

    Summary
    In the Ipamorelin group alone, in vitro treatment with Ipamorelin (10(-8) M), or GHRP 6 (10(-8) M), or GHRH (10(-8) M) for 4 hours, increased the percentage of somatotroph cells, without modifying the ratio of strongly/weakly immunostained GH cells.
    1 context sentence
    Summary · context
    pituitary cell cultures obtained from young female rats receiving Ipamorelin over 21 days (Ipamorelin group) and the effects were compared with those of GHRH (GHRH group) or saline (saline group
  10. 10LabEx vivo tissueEfficacy outcome

    In pituitary cell cultures from rats pretreated with ipamorelin, GHRP‑6 increased intracellular GH content; no such increase was reported in the other groups.

    In plain wordsIn rat pituitary cell cultures, GHRP‑6 raised growth hormone content inside cells, only in cells from rats pretreated with ipamorelin.

    Peptide
    GHRP-6
    Outcome
    IncreaseIntracellular GH content in somatotroph cells
    Study

    ratn: not reported in source

    primary pituitary cell cultures from young female rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10^-8 M · 4 hoursAs given in this study (rat).

    Source sentences

    Summary
    Only in the Ipamorelin group did Ipamorelin (10(-8) M), GHRP 6 (10(-8) M) and GHRH (10(-8) M) prompt increased intracellular GH content.
    1 context sentence
    Summary · context
    pituitary cell cultures obtained from young female rats receiving Ipamorelin over 21 days (Ipamorelin group) and the effects were compared with those of GHRH (GHRH group) or saline (saline group

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 36Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 34 times, first on 9 Oct 2026, 18:17 UTC. The status did not change between them.

    Study results updated

  2. Version 2

    9 Oct 2026, 03:13 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

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